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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated MAPK cascade
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Accession:GO:0032873 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
Synonyms:exact_synonym: down regulation of stress-activated MAPK cascade;   downregulation of stress-activated MAPK cascade;   negative regulation of p38 MAPK signaling;   negative regulation of p38 MAPK signalling;   negative regulation of stress-activated MAPK signaling pathway;   negative regulation of stress-activated MAPK signalling pathway;   negative regulation of stress-activated MAPKKK cascade;   negative regulation of stress-activated MAPKKK signaling pathway;   negative regulation of stress-activated MAPKKK signalling pathway
 narrow_synonym: inhibition of stress-activated MAPK cascade


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negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP10 dual specificity phosphatase 10 ISO (MGI:MGI:4366202|PMID:19696743) MGI PMID:19696743 MGI:MGI:4366202 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G FOXM1 forkhead box M1 IMP (PMID:19696738) BHF-UCL PMID:19696738 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,681...2,877,155
Ensembl chr12:2,857,681...2,877,155
JBrowse link
G FOXO1 forkhead box O1 IDA (PMID:19696738) BHF-UCL PMID:19696738 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISS BHF-UCL GO_REF:0000024 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G IGBP1 immunoglobulin binding protein 1 IMP (PMID:17438131) UniProtKB PMID:17438131 NCBI chr  X:70,133,447...70,166,324
Ensembl chr  X:70,133,447...70,166,324
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISS UniProtKB GO_REF:0000024 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G PBK PDZ binding kinase IEA Ensembl GO_REF:0000107 NCBI chr 8:27,809,624...27,837,817
Ensembl chr 8:27,809,624...27,838,082
JBrowse link
G PPIA peptidylprolyl isomerase A IMP (PMID:26095851) UniProt PMID:26095851 NCBI chr 7:44,795,960...44,803,117
Ensembl chr 7:44,796,680...44,824,564
JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 IDA (PMID:11096076) CAFA PMID:11096076 NCBI chr 3:49,095,932...49,104,758
Ensembl chr 3:49,095,932...49,105,130
JBrowse link
negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated ISS UniProtKB GO_REF:0000024 NCBI chr 1:222,668,013...222,712,895
Ensembl chr 1:222,668,013...222,713,210
JBrowse link
G AKT1 AKT serine/threonine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor TAS (PMID:12817471) UniProtKB PMID:12817471 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) MGI PMID:17081782 MGI:MGI:3693042 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CYLD CYLD lysine 63 deubiquitinase IDA (PMID:29291351) UniProtKB PMID:29291351 NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935
JBrowse link
G DACT1 dishevelled binding antagonist of beta catenin 1 IDA
IBA
(PMID:17197390)
(PMID:21873635)
UniProtKB
GO_Central
PMID:17197390, PMID:21873635 NCBI chr14:58,634,061...58,648,321
Ensembl chr14:58,633,967...58,648,321
JBrowse link
G DUSP10 dual specificity phosphatase 10 IDA
IBA
(PMID:10391943)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:10391943, PMID:21873635 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISS BHF-UCL GO_REF:0000024 NCBI chr 2:183,078,747...183,100,008
Ensembl chr 2:183,078,559...183,100,008
JBrowse link
G DUSP3 dual specificity phosphatase 3 IMP
IBA
IDA
(PMID:19010898)
(PMID:21873635)
(PMID:11085983)
UniProtKB
GO_Central
PMID:11085983, PMID:19010898, PMID:21873635 NCBI chr17:43,766,125...43,778,977
Ensembl chr17:43,766,125...43,778,977
JBrowse link
G F2RL1 F2R like trypsin receptor 1 IDA (PMID:19781631) UniProtKB PMID:19781631 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315
JBrowse link
G FKTN fukutin IMP (PMID:18808525) BHF-UCL PMID:18808525 NCBI chr 9:105,558,117...105,655,950
Ensembl chr 9:105,558,122...105,653,820
Ensembl chr 9:105,558,122...105,653,820
JBrowse link
G GPS2 G protein pathway suppressor 2 IDA (PMID:11931768) UniProtKB PMID:11931768 NCBI chr17:7,312,661...7,315,360
Ensembl chr17:7,311,324...7,315,564
JBrowse link
G HDAC3 histone deacetylase 3 IMP (PMID:11931768) UniProtKB PMID:11931768 NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849
JBrowse link
G ITCH itchy E3 ubiquitin protein ligase ISS BHF-UCL GO_REF:0000024 NCBI chr20:34,363,273...34,511,773
Ensembl chr20:34,363,241...34,540,748
JBrowse link
G KLHL31 kelch like family member 31 IMP (PMID:18719355) UniProt PMID:18719355 NCBI chr 6:53,647,916...53,665,854
Ensembl chr 6:53,647,916...53,665,756
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465
JBrowse link
G MARVELD3 MARVEL domain containing 3 IMP (PMID:24567356) MGI PMID:24567356 NCBI chr16:71,626,180...71,641,965
Ensembl chr16:71,626,161...71,642,114
JBrowse link
G MECOM MDS1 and EVI1 complex locus IMP (PMID:10856240) UniProtKB PMID:10856240 NCBI chr 3:169,083,506...169,663,781
Ensembl chr 3:169,083,499...169,663,775
JBrowse link
G MEN1 menin 1 IDA (PMID:12226747) UniProtKB PMID:12226747 NCBI chr11:64,803,514...64,811,294
Ensembl chr11:64,803,510...64,811,294
JBrowse link
G NCOR1 nuclear receptor corepressor 1 IDA (PMID:11931768) UniProtKB PMID:11931768 NCBI chr17:16,029,157...16,216,475
Ensembl chr17:16,029,157...16,218,185
JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr17:2,593,210...2,685,617
Ensembl chr17:2,593,210...2,685,615
JBrowse link
G PER1 period circadian regulator 1 ISS UniProtKB GO_REF:0000024 NCBI chr17:8,140,470...8,156,360
Ensembl chr17:8,140,472...8,156,506
JBrowse link
G PINK1 PTEN induced kinase 1 TAS (PMID:18221368) ParkinsonsUK-UCL PMID:18221368 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISS ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,771
Ensembl chr 6:161,347,417...162,727,771
JBrowse link
G SFRP4 secreted frizzled related protein 4 ISO RGD PMID:18567805 RGD:4107045 NCBI chr 7:37,905,932...37,916,817
Ensembl chr 7:37,905,932...38,025,695
JBrowse link
G SH3RF2 SH3 domain containing ring finger 2 ISS UniProtKB GO_REF:0000024 NCBI chr 5:145,936,570...146,081,773
Ensembl chr 5:145,936,578...146,081,791
JBrowse link
G SIRPA signal regulatory protein alpha ISS ARUK-UCL GO_REF:0000024 NCBI chr20:1,894,167...1,940,592
Ensembl chr20:1,894,167...1,940,592
JBrowse link
G TAOK3 TAO kinase 3 IDA (PMID:10559204) HGNC PMID:10559204 NCBI chr12:118,149,801...118,372,950
Ensembl chr12:118,149,801...118,372,907
JBrowse link
G ZMYND11 zinc finger MYND-type containing 11 IMP (PMID:20732415) UniProtKB PMID:20732415 NCBI chr10:130,088...254,637
Ensembl chr10:134,465...254,637
JBrowse link
G ZNF675 zinc finger protein 675 IDA (PMID:11751921) UniProtKB PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated IDA (PMID:17681137) MGI PMID:17681137 NCBI chr 1:222,668,013...222,712,895
Ensembl chr 1:222,668,013...222,713,210
JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 IMP (PMID:24512202) UniProtKB PMID:24512202 NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907
JBrowse link
G DUSP10 dual specificity phosphatase 10 IDA
IBA
(PMID:10391943)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:10391943, PMID:21873635 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISS BHF-UCL GO_REF:0000024 NCBI chr 2:183,078,747...183,100,008
Ensembl chr 2:183,078,559...183,100,008
JBrowse link
G GSTP1 glutathione S-transferase pi 1 IDA (PMID:16636664) BHF-UCL PMID:16636664 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HIPK3 homeodomain interacting protein kinase 3 ISS UniProtKB GO_REF:0000024 NCBI chr11:33,256,672...33,357,023
Ensembl chr11:33,256,672...33,357,023
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISS UniProtKB GO_REF:0000024 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465
JBrowse link
G NPPA natriuretic peptide A IDA (PMID:22399583) UniProt PMID:22399583 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G PDCD4 programmed cell death 4 ISS UniProtKB GO_REF:0000024 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IMP (PMID:23991106) UniProtKB PMID:23991106 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
G SERPINB3 serpin family B member 3 IMP (PMID:21383048) UniProtKB PMID:21383048 NCBI chr18:63,655,197...63,661,893
Ensembl chr18:63,655,197...63,661,893
JBrowse link
G SFRP1 secreted frizzled related protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:41,261,962...41,309,473
Ensembl chr 8:41,261,962...41,309,473
JBrowse link
G SFRP2 secreted frizzled related protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083
JBrowse link
G SFRP5 secreted frizzled related protein 5 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr10:97,766,751...97,771,999
Ensembl chr10:97,766,751...97,771,999
JBrowse link
G TP73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:MGI:3574697 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
G ZNF675 zinc finger protein 675 IDA (PMID:11751921) BHF-UCL PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase IDA (PMID:29291351) UniProtKB PMID:29291351 NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 IMP (PMID:20551903) UniProtKB PMID:20551903 NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330
JBrowse link
G DUSP1 dual specificity phosphatase 1 IMP
IBA
(PMID:22991462)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:21873635, PMID:22991462 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G DUSP10 dual specificity phosphatase 10 NAS
IDA
(PMID:23993976)
(PMID:10391943)
BHF-UCL PMID:10391943, PMID:23993976 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G EZR ezrin IMP (PMID:20551903) UniProtKB PMID:20551903 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 ISO (MGI:MGI:3822965|PMID:18681888) MGI PMID:18681888 MGI:MGI:3822965 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IEA
IBA
IMP
(PMID:21873635)
(PMID:23991106)
Ensembl
GO_Central
UniProtKB
PMID:21873635, PMID:23991106 GO_REF:0000107 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    cellular process 17686
      regulation of cellular process 12035
        regulation of cellular response to stress 763
          regulation of stress-activated protein kinase signaling cascade 202
            regulation of stress-activated MAPK cascade 199
              negative regulation of stress-activated MAPK cascade 52
                negative regulation of JNK cascade + 41
                negative regulation of MAPK cascade involved in cell wall organization or biogenesis 0
                negative regulation of p38MAPK cascade 7
Path 2
Term Annotations click to browse term
  biological_process 18670
    metabolic process 12302
      organic substance metabolic process 11737
        macromolecule metabolic process 10194
          protein metabolic process 6198
            protein modification process 4442
              cellular protein modification process 4442
                protein phosphorylation 2154
                  signal transduction by protein phosphorylation 1012
                    MAPK cascade 1002
                      regulation of MAPK cascade 791
                        regulation of stress-activated MAPK cascade 199
                          negative regulation of stress-activated MAPK cascade 52
                            negative regulation of JNK cascade + 41
                            negative regulation of MAPK cascade involved in cell wall organization or biogenesis 0
                            negative regulation of p38MAPK cascade 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.