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ONTOLOGY REPORT - ANNOTATIONS


Term:activin receptor signaling pathway
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Accession:GO:0032924 term browser browse the term
Definition:A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: activin receptor signalling pathway


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activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 ISO
IEA
(PMID:18326817), (PMID:19506109)
GO_REF:0000107
RGD
Ensembl
PMID:18326817, PMID:19506109 GO_REF:0000107 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Acvr1b activin A receptor type 1B ISO
IBA
(MGI:MGI:3619747|PMID:16115198)
PMID:21873635
(PMID:9884026), (PMID:9892009)
RGD PMID:9884026, PMID:9892009, PMID:16115198, PMID:21873635 MGI:MGI:3619747, RGD:13792537 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr1c activin A receptor type 1C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
JBrowse link
G Acvr2a activin A receptor type 2A IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:12665502), (PMID:18326817)
Ensembl
RGD
PMID:12665502, PMID:18326817, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:32,947,901...33,034,598
Ensembl chr 3:32,947,378...33,034,282
JBrowse link
G Acvr2b activin A receptor type 2B ISO
IBA
IEA
(PMID:18326817)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:18326817, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Acvrl1 activin A receptor like type 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:144,052,202...144,060,678
Ensembl chr 7:144,052,061...144,060,685
JBrowse link
G Bmp10 bone morphogenetic protein 10 IEA
ISO
GO_REF:0000107
(PMID:16049014), (PMID:17068149)
Ensembl
RGD
PMID:16049014, PMID:17068149 GO_REF:0000107 NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728
JBrowse link
G Gdf2 growth differentiation factor 2 ISO (PMID:17068149) RGD PMID:17068149 NCBI chr16:10,267,510...10,293,545
Ensembl chr16:10,267,482...10,273,239
JBrowse link
G Gdf6 growth differentiation factor 6 ISO (PMID:16049014) RGD PMID:16049014 NCBI chr 5:23,056,345...23,072,666
Ensembl chr 5:23,056,347...23,074,599
JBrowse link
G Gdf7 growth differentiation factor 7 ISO (PMID:16049014) RGD PMID:16049014 NCBI chr 6:33,496,596...33,507,626
Ensembl chr 6:33,503,217...33,507,542
JBrowse link
G Hjv hemojuvelin BMP co-receptor ISO
IEA
UniProtKB:P27037 (PMID:18326817)
GO_REF:0000107
RGD
Ensembl
PMID:18326817 GO_REF:0000107 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317
JBrowse link
G Inhba inhibin subunit beta A ISO
ISS
(PMID:9884026)
GO_REF:0000024
RGD
BHF-UCL
PMID:9884026 GO_REF:0000024 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Inhbb inhibin subunit beta B IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16650820)
Ensembl
UniProt
RGD
PMID:16650820 GO_REF:0000024, GO_REF:0000107 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G LOC103690035 TGF-beta receptor type-1-like ISS
IBA
GO_REF:0000024
PMID:21873635
AgBase PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:64,565,358...64,585,219
Ensembl chr 5:64,566,804...64,584,309
JBrowse link
G Smad2 SMAD family member 2 ISO (PMID:15150278) RGD PMID:15150278 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:15150278) RGD PMID:15150278 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISS
IBA
GO_REF:0000024
PMID:21873635
AgBase PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
negative regulation of activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 ISO
IEA
(PMID:9884026)
GO_REF:0000107
RGD
Ensembl
PMID:9884026 GO_REF:0000107 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist ISO (PMID:9660951)
(MGI:MGI:1858315|PMID:10748465)
RGD PMID:9660951, PMID:10748465 MGI:MGI:1858315 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Fst follistatin ISO
IBA
(PMID:11948405), (PMID:12697670), (PMID:12702211)
PMID:21873635
RGD PMID:11948405, PMID:12697670, PMID:12702211, PMID:21873635 RGD:13792537 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457
JBrowse link
G Fstl3 follistatin like 3 ISO
IBA
(PMID:11948405), (PMID:12697670)
PMID:21873635
RGD PMID:11948405, PMID:12697670, PMID:21873635 RGD:13792537 NCBI chr 7:12,806,031...12,810,556
Ensembl chr 7:12,804,919...12,810,570
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 ISO (PMID:11266516) RGD PMID:11266516 NCBI chr  X:136,792,637...136,808,107
Ensembl chr  X:136,792,643...136,807,885
JBrowse link
G Lemd3 LEM domain containing 3 ISO (PMID:15647271) RGD PMID:15647271 NCBI chr 7:62,976,671...63,045,860
Ensembl chr 7:62,996,336...63,045,728
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:1353670|PMID:10681527)
Ensembl
UniProt
RGD
PMID:10681527 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1353670 NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
JBrowse link
G Mir210 microRNA 210 ISO (MGI:MGI:3851892|PMID:19520079) RGD PMID:19520079 MGI:MGI:3851892 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Ski SKI proto-oncogene ISO (PMID:14699069) RGD PMID:14699069 NCBI chr 5:172,556,196...172,623,878
Ensembl chr 5:172,559,135...172,623,899
JBrowse link
G Synj2bp synaptojanin 2 binding protein ISO (MGI:MGI:3623710|PMID:16648306) RGD PMID:16648306 MGI:MGI:3623710 NCBI chr 6:105,224,166...105,261,549
Ensembl chr 6:105,224,166...105,261,549
JBrowse link
negative regulation of nodal receptor complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lefty1 left right determination factor 1 ISO (MGI:MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:MGI:3042530 NCBI chr13:99,212,778...99,217,786
Ensembl chr13:99,214,389...99,217,786
JBrowse link
negative regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO
IBA
(MGI:MGI:3809364|PMID:18716284), (MGI:MGI:5437437|PMID:17197390)
PMID:21873635
RGD PMID:17197390, PMID:18716284, PMID:21873635 MGI:MGI:3809364, MGI:MGI:5437437, RGD:13792537 NCBI chr 1:56,159,435...56,169,443
Ensembl chr 1:56,159,426...56,168,351
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 ISO (MGI:MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
G Lefty1 left right determination factor 1 ISO (MGI:MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:MGI:3042530 NCBI chr13:99,212,778...99,217,786
Ensembl chr13:99,214,389...99,217,786
JBrowse link
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B ISO UniProtKB:P43021 (PMID:11389842) RGD PMID:11389842 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr1c activin A receptor type 1C ISO
IEA
(PMID:15150278)
GO_REF:0000107
RGD
Ensembl
PMID:15150278 GO_REF:0000107 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
JBrowse link
G Cfc1 cripto, FRL-1, cryptic family 1 ISO
IBA
(MGI:MGI:5318034|PMID:12052855)
PMID:21873635
RGD PMID:12052855, PMID:21873635 MGI:MGI:5318034, RGD:13792537 NCBI chr 9:41,045,352...41,051,979
Ensembl chr 9:41,045,363...41,052,024
JBrowse link
G Nodal nodal growth differentiation factor ISO (MGI:MGI:5318034|PMID:12052855) RGD PMID:12052855 MGI:MGI:5318034 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Smad2 SMAD family member 2 ISO (PMID:15150278) RGD PMID:15150278 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:15150278) RGD PMID:15150278 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 ISO
IBA
UniProtKB:P43021 (MGI:MGI:5318034|PMID:12052855), (MGI:MGI:5447629|PMID:11389842)
PMID:21873635
RGD PMID:11389842, PMID:12052855, PMID:21873635 MGI:MGI:5318034, MGI:MGI:5447629, RGD:13792537 NCBI chr 8:119,215,266...119,220,909
Ensembl chr 8:119,215,495...119,219,232
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 ISO MGI:MGI:1915299 (MGI:MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:MGI:4430444 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tgif2 TGFB-induced factor homeobox 2 ISO MGI:MGI:1194497 (MGI:MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:MGI:4430444 NCBI chr 3:152,906,961...152,924,380
Ensembl chr 3:152,909,189...152,924,377
JBrowse link
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 ISO (MGI:MGI:3054669|PMID:15475956) RGD PMID:15475956 MGI:MGI:3054669 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Nodal nodal growth differentiation factor ISO (MGI:MGI:5315339|PMID:17507406) RGD PMID:17507406 MGI:MGI:5315339 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
positive regulation of activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B ISO (PMID:16720724) RGD PMID:16720724 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr2a activin A receptor type 2A ISO
IEA
(PMID:12665502)
GO_REF:0000107
RGD
Ensembl
PMID:12665502 GO_REF:0000107 NCBI chr 3:32,947,901...33,034,598
Ensembl chr 3:32,947,378...33,034,282
JBrowse link
G Acvr2b activin A receptor type 2B ISO
IEA
(PMID:8622651)
GO_REF:0000107
RGD
Ensembl
PMID:8622651 GO_REF:0000107 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Csnk2b casein kinase 2 beta ISO (PMID:19592636) RGD PMID:19592636 NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112
JBrowse link
G Fgf9 fibroblast growth factor 9 ISO (MGI:MGI:5444317|PMID:23034635) RGD PMID:23034635 MGI:MGI:5444317 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Nodal nodal growth differentiation factor ISO UniProtKB:Q8NER5 (PMID:15150278) RGD PMID:15150278 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Synj2bp synaptojanin 2 binding protein ISO (MGI:MGI:3623710|PMID:16648306) RGD PMID:16648306 MGI:MGI:3623710 NCBI chr 6:105,224,166...105,261,549
Ensembl chr 6:105,224,166...105,261,549
JBrowse link
G Zc3h3 zinc finger CCCH type containing 3 ISO MGI:MGI:1338944 (MGI:MGI:3619747|PMID:16115198) RGD PMID:16115198 MGI:MGI:3619747 NCBI chr 7:116,787,762...116,872,536
Ensembl chr 7:116,787,766...116,872,511
JBrowse link
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO (PMID:17239842) RGD PMID:17239842 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Zic2 Zic family member 2 ISO MGI:MGI:1862004 (MGI:MGI:5584215|PMID:24585447) RGD PMID:24585447 MGI:MGI:5584215 NCBI chr15:108,908,366...108,913,812
Ensembl chr15:108,908,607...108,912,737
JBrowse link
regulation of activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 ISO MGI:MGI:1859647 (MGI:MGI:3588480|PMID:15958512) RGD PMID:15958512 MGI:MGI:3588480 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:16720724) RGD PMID:16720724 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Men1 menin 1 IMP RGD PMID:15031321 RGD:2290185 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Smad7 SMAD family member 7 ISO
IEA
(PMID:16720724)
GO_REF:0000107
RGD
Ensembl
PMID:16720724 GO_REF:0000107 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact1 dishevelled-binding antagonist of beta-catenin 1 NOT ISO (PMID:17197390)
(MGI:MGI:5437437|PMID:17197390)
RGD PMID:17197390 MGI:MGI:5437437 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 ISO (MGI:MGI:5487845|PMID:23473982) RGD PMID:23473982 MGI:MGI:5487845 NCBI chr 1:243,477,403...243,582,629
Ensembl chr 1:243,477,493...243,582,629
JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dand5 DAN domain BMP antagonist family member 5 ISO (MGI:MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          enzyme linked receptor protein signaling pathway 969
            transmembrane receptor protein serine/threonine kinase signaling pathway 387
              activin receptor signaling pathway 47
                activin receptor signaling pathway involved in heart jogging 0
                negative regulation of activin receptor signaling pathway + 13
                nodal signaling pathway + 17
                positive regulation of activin receptor signaling pathway + 10
                regulation of activin receptor signaling pathway + 28
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            cell surface receptor signaling pathway 2761
              enzyme linked receptor protein signaling pathway 969
                transmembrane receptor protein serine/threonine kinase signaling pathway 387
                  activin receptor signaling pathway 47
                    activin receptor signaling pathway involved in heart jogging 0
                    negative regulation of activin receptor signaling pathway + 13
                    nodal signaling pathway + 17
                    positive regulation of activin receptor signaling pathway + 10
                    regulation of activin receptor signaling pathway + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.