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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrapyrrole biosynthetic process
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Accession:GO:0033014 term browser browse the term
Definition:The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms:exact_synonym: tetrapyrrole anabolism;   tetrapyrrole biosynthesis;   tetrapyrrole formation;   tetrapyrrole synthesis


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tetrapyrrole biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:2301695
RGD:1600115
RGD:2301691
RGD:2301704
RGD:2301858
cobalamin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mmab metabolism of cobalamin associated B JBrowse link 12 47,920,712 47,935,438 RGD:1600115
G Mmachc metabolism of cobalamin associated C JBrowse link 5 135,555,587 135,561,723 RGD:1624291
RGD:13792537
heme a biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:1624291
RGD:1600115
G Cox15 cytochrome c oxidase assembly homolog COX15 JBrowse link 1 263,494,850 263,511,510 RGD:1624291
RGD:13792537
heme biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1599020
RGD:13792537
RGD:1624291
RGD:1600115
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1624291
RGD:1600115
G Atp5if1 ATP synthase inhibitory factor subunit 1 JBrowse link 5 150,719,570 150,723,287 RGD:1624291
RGD:13792537
RGD:1600115
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:1600961
RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1600961
RGD:13792537
RGD:1624291
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:1600115
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:13792537
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1624291
RGD:1600115
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1600961
RGD:13792537
RGD:1624291
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:1624291
RGD:1600115
G Slc25a39 solute carrier family 25, member 39 JBrowse link 10 90,351,899 90,356,905 RGD:1600115
G Tmem14c transmembrane protein 14C JBrowse link 17 21,571,510 21,577,651 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:70052
RGD:13792537
RGD:1624291
RGD:2301379
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:1624291
RGD:13792537
heme O biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:1600115
porphyrin-containing compound biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb6 ATP binding cassette subfamily B member 6 JBrowse link 9 82,373,950 82,382,228 RGD:1624291
RGD:1600115
G Ank1 ankyrin 1 JBrowse link 16 73,681,422 73,912,605 RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1624291
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1599180
RGD:1624291
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:1624291
G Spta1 spectrin, alpha, erythrocytic 1 JBrowse link 13 92,264,231 92,340,091 RGD:1624291
RGD:1600115
G Sptb spectrin, beta, erythrocytic JBrowse link 6 99,657,144 99,783,189 RGD:1624291
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:4144825
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:1624291
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1600115
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:1600115
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1600115
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:4145128
RGD:13792537
RGD:1600115
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:1600115
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:1624291
RGD:1600115
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:1600115
regulation of heme biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Srrd SRR1 domain containing JBrowse link 12 50,315,876 50,321,488 RGD:1624291
G Tmem14c transmembrane protein 14C JBrowse link 17 21,571,510 21,577,651 RGD:1624291
uroporphyrinogen III biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:4144811
RGD:13792537
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18008
    metabolic process 10729
      biosynthetic process 5405
        cellular biosynthetic process 5233
          heterocycle biosynthetic process 3590
            tetrapyrrole biosynthetic process 25
              cobalamin biosynthetic process + 2
              corrin biosynthetic process 0
              negative regulation of tetrapyrrole biosynthetic process + 0
              phytochromobilin biosynthetic process 0
              porphyrin-containing compound biosynthetic process + 23
              positive regulation of tetrapyrrole biosynthetic process + 0
              regulation of tetrapyrrole biosynthetic process + 2
              tetrapyrrole biosynthetic process from glutamate + 0
              tetrapyrrole biosynthetic process from glycine and succinyl-CoA + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.