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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrapyrrole biosynthetic process
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Accession:GO:0033014 term browser browse the term
Definition:The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms:exact_synonym: tetrapyrrole anabolism;   tetrapyrrole biosynthesis;   tetrapyrrole formation;   tetrapyrrole synthesis


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tetrapyrrole biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase IDA
IMP
RGD PMID:9344466, PMID:12127573, PMID:6712591, PMID:18760440 RGD:2301695, RGD:2301691, RGD:2301704, RGD:2301858 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 ISO (PMID:12928484)
(MGI:MGI:3604933|PMID:16103131), (MGI:MGI:3640032|PMID:16782876)
RGD PMID:12928484, PMID:16103131, PMID:16782876 MGI:MGI:3604933, MGI:MGI:3640032 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 ISO
IBA
UniProtKB:Q7KZN9-1 (PMID:12474143)
PMID:21873635
RGD PMID:12474143, PMID:21873635 RGD:13792537 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
heme biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IDA
IBA
ISO
ISS
PMID:21873635
(MGI:MGI:53493|PMID:4959158), (MGI:MGI:53609|PMID:4981581), (MGI:MGI:63121|PMID:14050799)
GO_REF:0000024
(PMID:11032836)
RGD
UniProt
PMID:4959158, PMID:4981581, PMID:11032836, PMID:14050799, PMID:1764448, PMID:21873635 GO_REF:0000024, MGI:MGI:53493, MGI:MGI:53609, MGI:MGI:63121, RGD:1599020, RGD:13792537 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 ISO
IBA
ISS
(MGI:MGI:3694153|PMID:9446639)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9446639, PMID:21873635 GO_REF:0000024, MGI:MGI:3694153, RGD:13792537 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 ISO
IBA
ISS
(PMID:23135403)
PMID:21873635
GO_REF:0000024
(MGI:MGI:5447588|PMID:23135403)
RGD
UniProt
PMID:23135403, PMID:21873635 GO_REF:0000024, MGI:MGI:5447588, RGD:13792537 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cpox coproporphyrinogen oxidase IDA
ISO
(MGI:MGI:77569|PMID:8407975) RGD PMID:8407975, PMID:3955059 MGI:MGI:77569, RGD:1600961 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Fech ferrochelatase IDA
IBA
ISO
PMID:21873635
(PMID:27599036)
MGI:MGI:1858114|MGI:MGI:2384729 (MGI:MGI:1327758|PMID:9989256), (MGI:MGI:3620268|PMID:16503645), (MGI:MGI:3696634|PMID:15496139), (MGI:MGI:3794459|PMID:16306232), (MGI:MGI:79136|PMID:8611576)
RGD PMID:8611576, PMID:9989256, PMID:15496139, PMID:16306232, PMID:16503645, PMID:27599036, PMID:3955059, PMID:21873635 MGI:MGI:1327758, MGI:MGI:3620268, MGI:MGI:3696634, MGI:MGI:3794459, MGI:MGI:79136, RGD:1600961, RGD:13792537 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fxn frataxin IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Hmbs hydroxymethylbilane synthase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hnf1a HNF1 homeobox A ISO MGI:MGI:2384429 (MGI:MGI:1352605|PMID:10617683) RGD PMID:10617683 MGI:MGI:1352605 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 ISS
ISO
IEA
GO_REF:0000024
(PMID:27599036)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:27599036 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Ppox protoporphyrinogen oxidase IDA
IBA
ISO
PMID:21873635
(PMID:7713909)
(MGI:MGI:3687447|PMID:3346226)
RGD PMID:3346226, PMID:7713909, PMID:3955059, PMID:21873635 MGI:MGI:3687447, RGD:1600961, RGD:13792537 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Slc11a2 solute carrier family 11 member 2 ISO
IEA
MGI:MGI:1856400 (MGI:MGI:3691553|PMID:11739192)
GO_REF:0000107
RGD
Ensembl
PMID:11739192 GO_REF:0000107, MGI:MGI:3691553 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc25a39 solute carrier family 25, member 39 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:90,351,899...90,356,905
Ensembl chr10:90,351,900...90,356,242
JBrowse link
G Tmem14c transmembrane protein 14C IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:21,571,510...21,577,651
Ensembl chr17:21,571,518...21,577,631
JBrowse link
G Urod uroporphyrinogen decarboxylase NAS
IBA
ISO
IC
PMID:21873635
MGI:MGI:2687172 (MGI:MGI:3703836|PMID:17360334)
RGD PMID:17360334, PMID:3658690, PMID:21873635, PMID:15736160 MGI:MGI:3703836, RGD:70052, RGD:13792537, RGD:2301379 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase ISO
IBA
(PMID:3805019)
PMID:21873635
RGD PMID:3805019, PMID:21873635 RGD:13792537 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
porphyrin-containing compound biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 ISO (PMID:17006453) RGD PMID:17006453 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Ank1 ankyrin 1 ISO MGI:MGI:1856298 (MGI:MGI:54462|PMID:658175) RGD PMID:658175 MGI:MGI:54462 NCBI chr16:73,681,422...73,912,605
Ensembl chr16:73,681,422...73,827,488
JBrowse link
G Fech ferrochelatase ISO MGI:MGI:2384729 (MGI:MGI:2384247|PMID:12149233) RGD PMID:12149233 MGI:MGI:2384247 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Hmbs hydroxymethylbilane synthase IDA uroporphyrin I
Urophorphyrin I
Uroporphyrinogen
Uroporphyrin I
RGD PMID:11786116, PMID:3963818, PMID:3702597, PMID:994723, PMID:6694518, PMID:1781034, PMID:6732900, PMID:971328, PMID:6893114, PMID:3179323, PMID:11202056 RGD:26923962, RGD:4144803, RGD:4144820, RGD:25440497, RGD:25330343, RGD:25440495, RGD:25394584, RGD:25394583, RGD:26923963, RGD:2301707, RGD:4144783 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ppox protoporphyrinogen oxidase IDA
ISO
(PMID:7713909) RGD PMID:7713909, PMID:3663105 RGD:1599180 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Slc11a2 solute carrier family 11 member 2 ISO MGI:MGI:1856400 (MGI:MGI:54462|PMID:658175) RGD PMID:658175 MGI:MGI:54462 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 ISO MGI:MGI:1856181|MGI:MGI:1856377 (MGI:MGI:54462|PMID:658175) RGD PMID:658175 MGI:MGI:54462 NCBI chr13:92,264,231...92,340,091
Ensembl chr13:92,264,231...92,340,083
JBrowse link
G Sptb spectrin, beta, erythrocytic ISO MGI:MGI:1856378 (MGI:MGI:54462|PMID:658175) RGD PMID:658175 MGI:MGI:54462 NCBI chr 6:99,657,144...99,783,189
Ensembl chr 6:99,659,651...99,783,047
JBrowse link
G Urod uroporphyrinogen decarboxylase IDA RGD PMID:12381387 RGD:4144825 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase ISO MGI:MGI:3620007 (MGI:MGI:72967|PMID:7607680) RGD PMID:7607680 MGI:MGI:3620006, MGI:MGI:72967 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a9 solute carrier family 6 member 9 IEA
ISO
GO_REF:0000107
(MGI:MGI:6450351|PMID:28495915)
Ensembl
RGD
PMID:28495915 GO_REF:0000107, MGI:MGI:6450351 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Cpox coproporphyrinogen oxidase IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:3814086, PMID:21873635 GO_REF:0000041, RGD:4145128, RGD:13792537 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Hmbs hydroxymethylbilane synthase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO
IEA
MGI:MGI:2181660 (MGI:MGI:3695992|PMID:15831703)
GO_REF:0000107
RGD
Ensembl
PMID:15831703 GO_REF:0000107, MGI:MGI:3695992 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Ppox protoporphyrinogen oxidase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Urod uroporphyrinogen decarboxylase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srrd SRR1 domain containing ISO
IEA
(MGI:MGI:6282940|PMID:28802827)
GO_REF:0000107
RGD
Ensembl
PMID:28802827 GO_REF:0000107, MGI:MGI:6282940 NCBI chr12:50,315,876...50,321,488
Ensembl chr12:50,315,933...50,321,144
JBrowse link
G Tmem14c transmembrane protein 14C ISO MGI:MGI:4351741 (MGI:MGI:5581691|PMID:25157825) RGD PMID:25157825 MGI:MGI:5581691 NCBI chr17:21,571,510...21,577,651
Ensembl chr17:21,571,518...21,577,631
JBrowse link
uroporphyrinogen III biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uros uroporphyrinogen III synthase IDA
IBA
ISO
PMID:21873635
(PMID:18004775), (PMID:3174619), (PMID:3805019)
RGD PMID:3174619, PMID:3805019, PMID:18004775, PMID:17763925, PMID:21873635 RGD:4144811, RGD:13792537 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      biosynthetic process 6217
        cellular biosynthetic process 6052
          heterocycle biosynthetic process 3960
            tetrapyrrole biosynthetic process 25
              cobalamin biosynthetic process + 0
              corrin biosynthetic process 0
              negative regulation of tetrapyrrole biosynthetic process + 0
              phytochromobilin biosynthetic process 0
              porphyrin-containing compound biosynthetic process + 25
              positive regulation of tetrapyrrole biosynthetic process + 1
              regulation of tetrapyrrole biosynthetic process + 3
              tetrapyrrole biosynthetic process from glutamate + 0
              tetrapyrrole biosynthetic process from glycine and succinyl-CoA + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.