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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA recombinase mediator complex
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Accession:GO:0033061 term browser browse the term
Definition:A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA.
Comment:Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.


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Rad51B-Rad51C-Rad51D-XRCC2 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad51b RAD51 paralog B JBrowse link 6 102,473,978 103,018,185 RGD:1624291
RGD:13792537
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:1624291
RGD:13792537
G Rad51d RAD51 paralog D JBrowse link 10 70,222,703 70,241,352 RGD:1624291
RGD:13792537
G Xrcc2 X-ray repair cross complementing 2 JBrowse link 4 5,842,013 5,860,516 RGD:1624291
RGD:13792537
Rad51C-XRCC3 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:1624291
RGD:13792537
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:1624291
RGD:13792537
Swi5-Sfr1 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07067300.1 RGD:13792537
G Sfr1 SWI5-dependent homologous recombination repair protein 1 JBrowse link 1 267,505,336 267,509,350 RGD:1600115
RGD:13792537
RGD:1624291
G Swi5 SWI5 homologous recombination repair protein JBrowse link 3 11,307,981 11,317,049 RGD:1624291
RGD:13792537
RGD:1600115

Term paths to the root
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Term Annotations click to browse term
  cellular_component 19809
    protein-containing complex 5770
      DNA recombinase mediator complex 8
        Rad51B-Rad51C complex 0
        Rad51B-Rad51C-Rad51D-XRCC2 complex 4
        Rad51C-XRCC3 complex 2
        Rhp55-Rhp57 complex 0
        Swi5-Sfr1 complex 3
        XRCC2-RAD51D complex 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.