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Term:Weibel-Palade body
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Accession:GO:0033093 term browser browse the term
Definition:A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.
Synonyms:xref: Wikipedia:Weibel-Palade_body

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Weibel-Palade body term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ece1 endothelin converting enzyme 1 JBrowse link 5 156,215,469 156,318,652 RGD:1624291
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:8662311
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:10047177
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:1600115
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      endomembrane system 3858
        secretory granule 394
          Weibel-Palade body 5
Path 2
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          vesicle 1980
            intracellular vesicle 1827
              cytoplasmic vesicle 1822
                secretory vesicle 650
                  secretory granule 394
                    Weibel-Palade body 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.