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Term:proton-transporting V-type ATPase complex
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Accession:GO:0033176 term browser browse the term
Definition:A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.
Synonyms:exact_synonym: hydrogen-translocating V-type ATPase complex


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proton-transporting V-type ATPase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v1d ATPase H+ transporting V1 subunit D JBrowse link 6 102,032,271 102,047,754 RGD:1624291
RGD:13792537
plasma membrane proton-transporting V-type ATPase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6ap1 ATPase H+ transporting accessory protein 1 JBrowse link X 156,407,973 156,415,053 RGD:13792537
G Atp6ap1l ATPase H+ transporting accessory protein 1 like JBrowse link 2 19,781,375 19,809,355 RGD:13792537
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 JBrowse link 19 37,481,782 37,525,762 RGD:13792537
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:13792537
proton-transporting V-type ATPase, V0 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07030494.1 RGD:1600115
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 JBrowse link 12 37,368,321 37,398,233 RGD:1600115
G Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B RGD:1600115
G Atp6v0c ATPase H+ transporting V0 subunit C JBrowse link 10 13,537,031 13,543,407 RGD:1600115
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 JBrowse link 19 37,481,782 37,525,762 RGD:1600115
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:1600115
G Atp6v0e1 ATPase H+ transporting V0 subunit e1 JBrowse link 10 16,769,857 16,792,930 RGD:1600115
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 JBrowse link 4 78,168,117 78,171,265 RGD:1600115
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1600115
G Tctn2 tectonic family member 2 JBrowse link 12 37,400,896 37,427,256 RGD:1600115
proton-transporting V-type ATPase, V1 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6ap1 ATPase H+ transporting accessory protein 1 JBrowse link X 156,407,973 156,415,053 RGD:1600115
G Atp6ap1l ATPase H+ transporting accessory protein 1 like JBrowse link 2 19,781,375 19,809,355 RGD:1600115
G Atp6v1a ATPase H+ transporting V1 subunit A JBrowse link 11 61,531,386 61,584,634 RGD:1600115
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 JBrowse link 4 115,417,100 115,435,754 RGD:1600115
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 JBrowse link 16 22,326,537 22,350,143 RGD:1600115
G Atp6v1c2 ATPase H+ transporting V1 subunit C2 JBrowse link 6 42,585,452 42,632,289 RGD:1600115
G Atp6v1f ATPase H+ transporting V1 subunit F JBrowse link 4 56,744,563 56,747,657 RGD:1600115
G Rnase4 ribonuclease A family member 4 JBrowse link 15 28,018,040 28,035,395 RGD:1600115
vacuolar proton-transporting V-type ATPase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07029470.2 RGD:13792537
G Atp6ap2 ATPase H+ transporting accessory protein 2 JBrowse link X 11,137,889 11,164,854 RGD:1624291
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 JBrowse link 10 88,914,264 88,967,736 RGD:13792537
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 JBrowse link 4 65,736,585 65,821,916 RGD:1624291
RGD:13792537
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 JBrowse link 19 37,481,782 37,525,762 RGD:1624291
RGD:13792537
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:1624291
RGD:13792537
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 JBrowse link 4 115,417,100 115,435,754 RGD:1624291
RGD:1600115
G Atp6v1f ATPase H+ transporting V1 subunit F JBrowse link 4 56,744,563 56,747,657 RGD:1624291
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 JBrowse link 5 79,367,663 79,373,843 RGD:1624291
RGD:13792537
G Atp6v1g2 ATPase H+ transporting V1 subunit G2 JBrowse link 20 4,821,265 4,824,829 RGD:632223
RGD:13792537
RGD:1624291
G Atp6v1g3 ATPase H+ transporting V1 subunit G3 JBrowse link 13 55,265,794 55,288,651 RGD:13792537
G Ccdc115 coiled-coil domain containing 115 JBrowse link 9 37,774,876 37,778,839 RGD:1624291
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:13792537
G Tmem199 transmembrane protein 199 JBrowse link 10 65,775,721 65,780,293 RGD:1624291
RGD:1600115
vacuolar proton-transporting V-type ATPase, V0 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 JBrowse link 10 88,914,264 88,967,736 RGD:1600115
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 JBrowse link 12 37,368,321 37,398,233 RGD:1600115
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 JBrowse link 4 65,736,585 65,821,916 RGD:1600115
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1600115
vacuolar proton-transporting V-type ATPase, V1 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 JBrowse link 7 77,678,853 77,716,658 RGD:13792537
G Atp6v1c2 ATPase H+ transporting V1 subunit C2 JBrowse link 6 42,585,452 42,632,289 RGD:13792537
G Atp6v1h ATPase H+ transporting V1 subunit H JBrowse link 5 14,262,352 14,367,898 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20118
    protein-containing complex 5962
      membrane protein complex 1244
        proton-transporting two-sector ATPase complex 59
          proton-transporting V-type ATPase complex 30
            plasma membrane proton-transporting V-type ATPase complex + 4
            proton-transporting V-type ATPase, V0 domain + 12
            proton-transporting V-type ATPase, V1 domain + 10
            vacuolar proton-transporting V-type ATPase complex + 17
Path 2
Term Annotations click to browse term
  cellular_component 20118
    cellular anatomical entity 19774
      membrane 10049
        membrane protein complex 1244
          proton-transporting two-sector ATPase complex 59
            proton-transporting V-type ATPase complex 30
              plasma membrane proton-transporting V-type ATPase complex + 4
              proton-transporting V-type ATPase, V0 domain + 12
              proton-transporting V-type ATPase, V1 domain + 10
              vacuolar proton-transporting V-type ATPase complex + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.