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ONTOLOGY REPORT - ANNOTATIONS


Term:tumor necrosis factor-mediated signaling pathway
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Accession:GO:0033209 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: tumor necrosis factor-mediated signalling pathway
 narrow_synonym: TNF-alpha-mediated signaling pathway;   tumor necrosis factor alpha-mediated signaling pathway
 related_synonym: adipocytokine signaling pathway


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tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn4 actinin alpha 4 ISO (PMID:25411248) RGD PMID:25411248 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Aim2 absent in melanoma 2 ISO (PMID:16432157) RGD PMID:16432157 NCBI chr13:91,919,834...91,963,080
Ensembl chr13:91,954,138...91,962,588
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Card14 caspase recruitment domain family, member 14 ISO (PMID:21302310) RGD PMID:21302310 NCBI chr10:108,440,480...108,469,012
Ensembl chr10:108,440,950...108,468,310
JBrowse link
G Cd70 Cd70 molecule IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:9,842,585...9,845,728
Ensembl chr 9:9,842,585...9,845,728
JBrowse link
G Cdip1 cell death-inducing p53 target 1 ISO UniProtKB:P01375 (PMID:17599062) RGD PMID:17599062 NCBI chr10:10,966,819...10,989,937
Ensembl chr10:10,967,658...10,989,936
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Commd7 COMM domain containing 7 ISO
IBA
(PMID:15799966)
PMID:21873635
RGD PMID:15799966, PMID:21873635 RGD:13792537 NCBI chr 3:149,101,242...149,115,227
Ensembl chr 3:149,101,243...149,115,209
JBrowse link
G Fas Fas cell surface death receptor IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Foxo3 forkhead box O3 ISO (PMID:15084260) RGD PMID:15084260 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:15084260), (PMID:25816133)
(MGI:MGI:5693235|PMID:15084260)
Ensembl
RGD
PMID:15084260, PMID:25816133, PMID:21873635 GO_REF:0000107, MGI:MGI:5693235, RGD:13792537 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ilk integrin-linked kinase ISO (PMID:21343177) RGD PMID:21343177 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Jak2 Janus kinase 2 ISO (PMID:8609418) RGD PMID:8609418 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kars lysyl-tRNA synthetase ISO
IBA
(PMID:15851690)
PMID:21873635
RGD PMID:15851690, PMID:21873635 RGD:13792537 NCBI chr19:44,212,205...44,231,209
Ensembl chr19:44,212,206...44,231,157
JBrowse link
G Krt18 keratin 18 ISO MGI:MGI:96705 (MGI:MGI:3711847|PMID:10747083) RGD PMID:10747083 MGI:MGI:3711847 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 ISO MGI:MGI:2178042|MGI:MGI:96692 (MGI:MGI:3711847|PMID:10747083) RGD PMID:10747083 MGI:MGI:3711847 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lims1 LIM zinc finger domain containing 1 ISO (PMID:21343177) RGD PMID:21343177 NCBI chr20:27,895,981...28,004,767
Ensembl chr20:27,954,433...28,002,082
JBrowse link
G LOC103694380 tumor necrosis factor-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,855,792...4,858,447
Ensembl chr20:4,855,829...4,858,447
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO (PMID:25038658) RGD PMID:25038658 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Plvap plasmalemma vesicle associated protein ISO (PMID:19420356) RGD PMID:19420356 NCBI chr16:19,906,354...19,918,668
Ensembl chr16:19,906,318...19,918,689
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO (PMID:8670418) RGD PMID:8670418 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:12656673) RGD PMID:12656673 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (PMID:21343177), (PMID:25411248) RGD PMID:21343177, PMID:25411248 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor IEA
ISO
GO_REF:0000107
(PMID:18676404)
Ensembl
RGD
PMID:18676404 GO_REF:0000107 NCBI chr 5:12,437,617...12,787,223
Ensembl chr 5:12,437,525...12,563,429
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (PMID:10848577) RGD PMID:10848577 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tmsb4x thymosin beta 4, X-linked ISO (PMID:21343177) RGD PMID:21343177 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
G Tnf tumor necrosis factor ISO
IBA
(MGI:MGI:63487|PMID:3898078)
(PMID:10748004), (PMID:31824476)
PMID:21873635
RGD PMID:3898078, PMID:10748004, PMID:31824476, PMID:21873635 MGI:MGI:63487, RGD:13792537 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A ISO (MGI:MGI:4413614|PMID:19940926) RGD PMID:19940926 MGI:MGI:4413614 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:123,453,799...123,456,289
Ensembl chr 7:123,453,788...123,456,268
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
JBrowse link
G Tnfrsf18 TNF receptor superfamily member 18 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:173,459,371...173,463,980
Ensembl chr 5:173,460,354...173,463,140
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IMP
ISO
IEA
(PMID:25816133)
GO_REF:0000107
RGD
Ensembl
PMID:25816133, PMID:20967881 GO_REF:0000107, RGD:5130945 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:173,447,784...173,450,474
Ensembl chr 5:173,447,784...173,450,474
JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO UniProtKB:O35305 (MGI:MGI:4413614|PMID:19940926) RGD PMID:19940926 MGI:MGI:4413614 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO
IBA
(MGI:MGI:5306317|PMID:14521928)
PMID:21873635
RGD PMID:14521928, PMID:21873635 MGI:MGI:5306317, RGD:13792537 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
G Tp53 tumor protein p53 ISO UniProtKB:P01375 (PMID:22499991) RGD PMID:22499991 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf1 TNF receptor-associated factor 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Traf2 Tnf receptor-associated factor 2 IMP
IBA
ISO
PMID:21873635
(PMID:11907583)
RGD PMID:11907583, PMID:10713108, PMID:21873635, PMID:20967881 RGD:2298798, RGD:13792537, RGD:5130945 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Traf3 Tnf receptor-associated factor 3 ISO
IBA
(PMID:20185819)
PMID:21873635
(MGI:MGI:3722053|PMID:17015635)
RGD PMID:17015635, PMID:20185819, PMID:21873635 MGI:MGI:3722053, RGD:13792537 NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
JBrowse link
G Traf4 Tnf receptor associated factor 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:65,418,688...65,424,802
Ensembl chr10:65,418,700...65,424,802
JBrowse link
G Traf5 TNF receptor-associated factor 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:110,758,556...110,801,871
Ensembl chr13:110,758,761...110,784,209
JBrowse link
G Traf6 TNF receptor associated factor 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Txndc17 thioredoxin domain containing 17 ISO (PMID:14607844) RGD PMID:14607844 NCBI chr10:58,776,792...58,779,764
Ensembl chr10:58,776,792...58,779,764
JBrowse link
G Umod uromodulin ISO
IEA
(MGI:MGI:6107740|PMID:28990932)
GO_REF:0000107
RGD
Ensembl
PMID:28990932 GO_REF:0000107, MGI:MGI:6107740 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:10604883)
GO_REF:0000024
RGD
UniProt
PMID:10604883 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Apoa1 apolipoprotein A1 ISO (PMID:21571275) RGD PMID:21571275 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Ccdc3 coiled-coil domain containing 3 ISO (PMID:25193116) RGD PMID:25193116 NCBI chr17:76,991,722...77,093,515
Ensembl chr17:76,995,043...77,093,308
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Gas6 growth arrest specific 6 ISO
ISS
(PMID:19657094)
GO_REF:0000024
RGD
UniProt
PMID:19657094 GO_REF:0000024 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (MGI:MGI:6148454|PMID:22424771) RGD PMID:22424771 MGI:MGI:6148454 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E ISO (PMID:11859126) RGD PMID:11859126 NCBI chr 2:198,360,837...198,363,399
Ensembl chr 2:198,360,998...198,361,378
JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B ISO (PMID:11821383) RGD PMID:11821383 NCBI chr10:57,755,957...57,847,867 JBrowse link
G Nol3 nucleolar protein 3 IEA
ISO
GO_REF:0000107
(MGI:MGI:5617337|PMID:24440909)
Ensembl
RGD
PMID:24440909 GO_REF:0000107, MGI:MGI:5617337 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 IEA
ISO
GO_REF:0000107
(MGI:MGI:5707586|PMID:18972444)
Ensembl
RGD
PMID:18972444 GO_REF:0000107, MGI:MGI:5707586 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO (PMID:24113711)
MGI:MGI:5441750 (MGI:MGI:5546581|PMID:23950925)
RGD PMID:23950925, PMID:24113711 MGI:MGI:5546581 NCBI chr 1:220,191,209...220,204,032
Ensembl chr 1:220,190,067...220,204,032
JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO (MGI:MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:MGI:4453084 NCBI chr 7:11,414,565...11,428,090
Ensembl chr 7:11,414,446...11,428,552
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(MGI:MGI:3530208|PMID:15696169)
GO_REF:0000024
RGD
UniProt
PMID:15696169 GO_REF:0000024, MGI:MGI:3530208 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ISO
ISS
(PMID:18450452)
GO_REF:0000024
RGD
UniProt
PMID:18450452 GO_REF:0000024 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Traip TRAF-interacting protein ISO (PMID:19151749) RGD PMID:19151749 NCBI chr 8:116,730,170...116,750,528
Ensembl chr 8:116,730,641...116,750,709
JBrowse link
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf11a TNF receptor superfamily member 11A ISO (PMID:18606301) RGD PMID:18606301 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO (PMID:18606301) RGD PMID:18606301 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA
(PMID:24813629)
GO_REF:0000107
RGD
Ensembl
PMID:24813629 GO_REF:0000107 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Casp1 caspase 1 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp4 caspase 4 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Cpne1 copine 1 ISO
IBA
(PMID:14674885)
PMID:21873635
RGD PMID:14674885, PMID:21873635 RGD:13792537 NCBI chr 3:151,617,733...151,625,448
NCBI chr 3:152,150,143...152,192,936
Ensembl chr 3:151,616,037...151,625,644
Ensembl chr 3:151,616,037...151,625,644
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO
ISS
(PMID:23453807)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:23453807 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rbm12 RNA binding motif protein 12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (MGI:MGI:6271183|PMID:30439713) RGD PMID:30439713 MGI:MGI:6271183 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO (MGI:MGI:5616328|PMID:11374864) RGD PMID:11374864 MGI:MGI:5616328 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Trim32 tripartite motif-containing 32 ISO (MGI:MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:MGI:4453084 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO (PMID:26707646) RGD PMID:26707646 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:5912943|PMID:28701375)
(PMID:26997266), (PMID:27458237), (PMID:27591049)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26997266, PMID:27458237, PMID:27591049, PMID:28701375 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5912943 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 ISO
IEA
(PMID:15701637)
GO_REF:0000107
RGD
Ensembl
PMID:15701637 GO_REF:0000107 NCBI chr 2:206,224,015...206,274,910
Ensembl chr 2:206,224,015...206,274,079
JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity ISO
IBA
(PMID:26997266)
(MGI:MGI:5804663|PMID:27523608), (MGI:MGI:6192867|PMID:29950720)
PMID:21873635
RGD PMID:26997266, PMID:27523608, PMID:29950720, PMID:21873635 MGI:MGI:5804663, MGI:MGI:6192867, RGD:13792537 NCBI chr 2:80,267,724...80,293,204
Ensembl chr 2:80,269,587...80,293,181
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO
ISS
(PMID:21455173)
(MGI:MGI:4947438|PMID:21455180), (MGI:MGI:4947439|PMID:21455173)
GO_REF:0000024
RGD
UniProt
PMID:21455173, PMID:21455180 GO_REF:0000024, MGI:MGI:4947438, MGI:MGI:4947439 NCBI chr 7:117,413,151...117,417,455
Ensembl chr 7:117,413,152...117,417,363
JBrowse link
G Spata2 spermatogenesis associated 2 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:MGI:5912943|PMID:28701375)
(PMID:27307491), (PMID:27458237), (PMID:27545878), (PMID:27591049)
UniProt
RGD
PMID:27307491, PMID:27458237, PMID:27545878, PMID:27591049, PMID:28701375, PMID:21873635 GO_REF:0000024, MGI:MGI:5912943, RGD:13792537 NCBI chr 3:164,229,211...164,239,483
Ensembl chr 3:164,230,852...164,239,250
JBrowse link
G Sphk1 sphingosine kinase 1 ISO
IEA
IMP
ISS
(PMID:20577214)
GO_REF:0000107
PMID:28284343
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20577214, PMID:28284343 GO_REF:0000024, GO_REF:0000107, RGD:14397556 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Syk spleen associated tyrosine kinase ISO
IEA
(PMID:19151749)
GO_REF:0000107
RGD
Ensembl
PMID:19151749 GO_REF:0000107 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
TNFSF11-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn18 claudin 18 ISO MGI:MGI:5007067 (MGI:MGI:5489769|PMID:22437732) RGD PMID:22437732 MGI:MGI:5489769 NCBI chr 8:107,933,725...107,960,656
Ensembl chr 8:107,934,860...107,952,530
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISO (MGI:MGI:3836131|PMID:17442941) RGD PMID:17442941 MGI:MGI:3836131 NCBI chr 2:198,821,377...198,831,533
Ensembl chr 2:198,823,366...198,836,372
JBrowse link
G Tjp2 tight junction protein 2 ISO (MGI:MGI:5489769|PMID:22437732) RGD PMID:22437732 MGI:MGI:5489769 NCBI chr 1:241,945,816...242,084,044
Ensembl chr 1:241,945,841...242,083,484
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A ISO
IBA
(PMID:18606301)
PMID:21873635
RGD PMID:18606301, PMID:21873635 RGD:13792537 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO (PMID:18606301)
(MGI:MGI:3785147|PMID:18269914), (MGI:MGI:3836131|PMID:17442941), (MGI:MGI:5489769|PMID:22437732)
RGD PMID:17442941, PMID:18269914, PMID:18606301, PMID:22437732 MGI:MGI:3785147, MGI:MGI:3836131, MGI:MGI:5489769 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    signaling 7580
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            tumor necrosis factor-mediated signaling pathway 81
              TNFSF11-mediated signaling pathway + 5
              negative regulation of tumor necrosis factor-mediated signaling pathway 15
              positive regulation of tumor necrosis factor-mediated signaling pathway 12
              regulation of tumor necrosis factor-mediated signaling pathway + 35
Path 2
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to chemical 6342
        response to organic substance 3865
          cellular response to organic substance 2845
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                tumor necrosis factor-mediated signaling pathway 81
                  TNFSF11-mediated signaling pathway + 5
                  negative regulation of tumor necrosis factor-mediated signaling pathway 15
                  positive regulation of tumor necrosis factor-mediated signaling pathway 12
                  regulation of tumor necrosis factor-mediated signaling pathway + 35
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.