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ONTOLOGY REPORT - ANNOTATIONS


Term:leptin-mediated signaling pathway
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Accession:GO:0033210 term browser browse the term
Definition:A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
Synonyms:exact_synonym: leptin-mediated signalling pathway
 related_synonym: adipocytokine signaling pathway


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leptin-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 IMP RGD PMID:18394428 RGD:2317907 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228
JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 ISO MGI:MGI:3521669 (MGI:MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:MGI:3836843 NCBI chr19:11,385,921...11,421,523
Ensembl chr19:11,386,024...11,421,498
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 ISO MGI:MGI:3045473 (MGI:MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:MGI:3836843 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Ebi3 Epstein-Barr virus induced 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:11,110,874...11,114,843
Ensembl chr 9:11,110,874...11,114,843
JBrowse link
G Lep leptin IDA
ISO
(MGI:MGI:5700303|PMID:16825198)
PMID:11677594
RGD PMID:16825198, PMID:9070213, PMID:11677594, PMID:9618284 MGI:MGI:5700303, RGD:2290293, RGD:10448951, RGD:2290294 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor IDA
IBA
ISO
IEA
PMID:21873635
(PMID:27037668)
GO_REF:0000107
(MGI:MGI:2652302|PMID:12594516)
RGD
Ensembl
PMID:12594516, PMID:27037668, PMID:9070213, PMID:21873635, PMID:9618284 GO_REF:0000107, MGI:MGI:2652302, RGD:2290293, RGD:13792537, RGD:2290294 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lepr_v1 leptin receptor, variant 1 IDA RGD PMID:9070213, PMID:9618284 RGD:2290293, RGD:2290294
G Lepr_v2 leptin receptor, variant 2 IDA RGD PMID:9070213, PMID:9618284 RGD:2290293, RGD:2290294
G Mkks McKusick-Kaufman syndrome ISO MGI:MGI:3526444 (MGI:MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:MGI:3836843 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link
G Mt3 metallothionein 3 ISO
ISS
(MGI:MGI:5299282|PMID:21726645)
GO_REF:0000024
RGD
UniProt
PMID:21726645 GO_REF:0000024, MGI:MGI:5299282 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:4821191|PMID:20620997) RGD PMID:20620997 MGI:MGI:4821191 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
IBA
ISS
(PMID:17344214)
PMID:21873635
(MGI:MGI:2652302|PMID:12594516), (MGI:MGI:5700303|PMID:16825198)
GO_REF:0000024
RGD
UniProt
PMID:12594516, PMID:16825198, PMID:17344214, PMID:21873635 GO_REF:0000024, MGI:MGI:2652302, MGI:MGI:5700303, RGD:13792537 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase ISS
ISO
GO_REF:0000024
(MGI:MGI:5634638|PMID:23554574)
UniProt
RGD
PMID:23554574 GO_REF:0000024, MGI:MGI:5634638 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
negative regulation of appetite by leptin-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbs2 Bardet-Biedl syndrome 2 ISO (MGI:MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:MGI:3836843 NCBI chr19:11,385,921...11,421,523
Ensembl chr19:11,386,024...11,421,498
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 ISO (MGI:MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:MGI:3836843 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Lep leptin IDA
IBA
PMID:11677594
PMID:21873635
UniProt
GO_Central
PMID:11677594, PMID:21873635 RGD:10448951, RGD:13792537 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mkks McKusick-Kaufman syndrome ISO (MGI:MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:MGI:3836843 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            leptin-mediated signaling pathway 13
              negative regulation of appetite by leptin-mediated signaling pathway 4
Path 2
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cellular response to stimulus 8920
        cellular response to chemical stimulus 3528
          cellular response to organic substance 2845
            cellular response to hormone stimulus 758
              cellular response to leptin stimulus 23
                leptin-mediated signaling pathway 13
                  negative regulation of appetite by leptin-mediated signaling pathway 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.