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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear DNA replication
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Accession:GO:0033260 term browser browse the term
Definition:The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
Synonyms:exact_synonym: DNA replication involved in S phase;   nuclear cell cycle DNA replication
 related_synonym: DNA replication during S phase


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nuclear DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 ISO MGI:MGI:4127920 (MGI:MGI:5763555|PMID:25404367) RGD PMID:25404367 MGI:MGI:5763555 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Donson DNA replication fork stabilization factor DONSON IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:31,834,608...31,847,751
Ensembl chr11:31,837,839...31,847,490
JBrowse link
G Zfp830 zinc finger protein 830 ISO
IBA
MGI:MGI:4950703 (MGI:MGI:4950701|PMID:21191184)
PMID:21873635
RGD PMID:21191184, PMID:21873635 MGI:MGI:4950701, RGD:13792537 NCBI chr10:70,118,250...70,119,714
Ensembl chr10:70,118,250...70,119,716
JBrowse link
DNA replication preinitiation complex assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO
IBA
(PMID:11125146)
PMID:21873635
RGD PMID:11125146, PMID:21873635 RGD:13792537 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Gmnn geminin, DNA replication inhibitor ISO (PMID:11125146) RGD PMID:11125146 NCBI chr17:42,302,523...42,310,783
Ensembl chr17:42,302,540...42,310,783
JBrowse link
DNA strand elongation involved in mitotic DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gins1 GINS complex subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:146,695,366...146,716,787
Ensembl chr 3:146,695,344...146,716,816
JBrowse link
mitotic DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm6 minichromosome maintenance complex component 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
mitotic DNA replication initiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm2 minichromosome maintenance complex component 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:8,973,861...9,039,616
Ensembl chr 5:8,978,010...9,038,594
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
mitotic DNA replication preinitiation complex assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc45 cell division cycle 45 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
mitotic DNA replication termination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtfdc1 replication termination factor 2 domain containing 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:170,443,895...170,473,456
Ensembl chr 3:170,443,855...170,473,456
JBrowse link
mitotic recombination-dependent replication fork processing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated ISO
IEA
(PMID:21076401)
GO_REF:0000107
RGD
Ensembl
PMID:21076401 GO_REF:0000107 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Rad51 RAD51 recombinase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
mitotic telomere maintenance via semi-conservative replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcna proliferating cell nuclear antigen ISO UniProtKB:Q0VGM9 (MGI:MGI:5522574|PMID:24115439) RGD PMID:24115439 MGI:MGI:5522574 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 ISO (MGI:MGI:5522574|PMID:24115439) RGD PMID:24115439 MGI:MGI:5522574 NCBI chr 3:176,818,012...176,856,531
Ensembl chr 3:176,818,437...176,856,531
JBrowse link
Okazaki fragment processing involved in mitotic DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 DNA ligase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758
JBrowse link
G LOC100911727 DNA ligase 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:75,224,143...75,264,441
Ensembl chr 1:75,233,703...75,264,293
JBrowse link
positive regulation of mitotic cell cycle DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr1 Fibroblast growth factor receptor 1 ISO
IEA
(MGI:MGI:79015|PMID:2161540)
GO_REF:0000107
RGD
Ensembl
PMID:2161540 GO_REF:0000107, MGI:MGI:79015 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
positive regulation of nuclear cell cycle DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX, chromatin remodeler IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5568153|PMID:24651726)
Ensembl
UniProt
RGD
PMID:24651726 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5568153 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Cdc7 cell division cycle 7 ISO (PMID:15668232) RGD PMID:15668232 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Dbf4 DBF4 zinc finger IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dbf4b DBF4 zinc finger B ISO (PMID:15668232) RGD PMID:15668232 NCBI chr10:90,710,468...90,723,313 JBrowse link
G Ino80 INO80 complex ATPase subunit ISO (PMID:20237820) RGD PMID:20237820 NCBI chr 3:111,186,371...111,266,542
Ensembl chr 3:111,187,711...111,266,542
JBrowse link
G Wiz WIZ zinc finger ISO (PMID:23545495) RGD PMID:23545495 NCBI chr 7:14,374,358...14,402,647
Ensembl chr 7:14,374,358...14,402,010
JBrowse link
pre-replicative complex assembly involved in nuclear cell cycle DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm2 minichromosome maintenance complex component 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:8,973,861...9,039,616
Ensembl chr 5:8,978,010...9,038,594
JBrowse link
G Orc3 origin recognition complex, subunit 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:50,019,159...50,075,533
Ensembl chr 5:50,020,815...50,075,454
JBrowse link
regulation of mitotic cell cycle DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zmpste24 zinc metallopeptidase STE24 ISO MGI:MGI:2180033 (MGI:MGI:3583382|PMID:15980864) RGD PMID:15980864 MGI:MGI:3583382 NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541
JBrowse link
regulation of nuclear cell cycle DNA replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase ISO (PMID:19734146) RGD PMID:19734146 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (MGI:MGI:2159541|PMID:11850834) RGD PMID:11850834 MGI:MGI:2159541 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Dach1 dachshund family transcription factor 1 ISO (MGI:MGI:5619482|PMID:16980615) RGD PMID:16980615 MGI:MGI:5619482 NCBI chr15:82,095,003...82,482,272
Ensembl chr15:82,099,159...82,482,009
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase IDA RGD PMID:9857069 RGD:632254 NCBI chr 9:98,514,599...98,536,586
Ensembl chr 9:98,514,584...98,536,581
JBrowse link
G Nuggc nuclear GTPase, germinal center associated ISO (PMID:19734146) RGD PMID:19734146 NCBI chr15:49,011,951...49,055,246
Ensembl chr15:49,010,492...49,055,237
JBrowse link
signal transduction involved in intra-S DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek2 checkpoint kinase 2 ISO (PMID:11298456) RGD PMID:11298456 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
telomere maintenance via semi-conservative replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Upf1 UPF1, RNA helicase and ATPase ISO (PMID:21829167) RGD PMID:21829167 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell cycle process 1210
        cell cycle DNA replication 42
          nuclear DNA replication 37
            DNA replication preinitiation complex assembly + 3
            DNA strand elongation involved in nuclear cell cycle DNA replication + 1
            mitotic DNA replication + 16
            negative regulation of nuclear cell cycle DNA replication + 1
            nuclear DNA replication DNA duplex unwinding + 0
            nuclear DNA replication DNA ligation + 0
            nuclear DNA replication termination + 1
            nuclear cell cycle DNA replication initiation + 5
            positive regulation of nuclear cell cycle DNA replication + 7
            pre-replicative complex assembly involved in nuclear cell cycle DNA replication + 8
            premeiotic DNA replication + 0
            regulation of nuclear cell cycle DNA replication + 14
            synthesis of RNA primer involved in nuclear cell cycle DNA replication + 0
            telomere maintenance via semi-conservative replication + 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        macromolecule metabolic process 10086
          cellular macromolecule metabolic process 8554
            cellular macromolecule biosynthetic process 5074
              DNA replication 256
                DNA-dependent DNA replication 153
                  cell cycle DNA replication 42
                    nuclear DNA replication 37
                      DNA replication preinitiation complex assembly + 3
                      DNA strand elongation involved in nuclear cell cycle DNA replication + 1
                      mitotic DNA replication + 16
                      negative regulation of nuclear cell cycle DNA replication + 1
                      nuclear DNA replication DNA duplex unwinding + 0
                      nuclear DNA replication DNA ligation + 0
                      nuclear DNA replication termination + 1
                      nuclear cell cycle DNA replication initiation + 5
                      positive regulation of nuclear cell cycle DNA replication + 7
                      pre-replicative complex assembly involved in nuclear cell cycle DNA replication + 8
                      premeiotic DNA replication + 0
                      regulation of nuclear cell cycle DNA replication + 14
                      synthesis of RNA primer involved in nuclear cell cycle DNA replication + 0
                      telomere maintenance via semi-conservative replication + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.