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Term:TSC1-TSC2 complex
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Accession:GO:0033596 term browser browse the term
Definition:A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
Synonyms:exact_synonym: tuberin-hamartin complex;   tuberous sclerosis complex

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TSC1-TSC2 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:1624291
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1600115
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:13792537

Term paths to the root
Path 1
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  cellular_component 19843
    protein-containing complex 5779
      TSC1-TSC2 complex 4
Path 2
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  cellular_component 19843
    intracellular 13806
      cytoplasm 10553
        cytosol 3815
          TSC1-TSC2 complex 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.