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ONTOLOGY REPORT - ANNOTATIONS


Term:mammary gland epithelial cell proliferation
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Accession:GO:0033598 term browser browse the term
Definition:The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


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mammary gland epithelial cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO MGI:3055737 (MGI:3054694|PMID:15340078) RGD PMID:15340078 MGI:3054694 NCBI chr 1:265,100,094...265,270,263
Ensembl chr 1:265,157,379...265,269,837
JBrowse link
G Ccnd1 cyclin D1 ISO MGI:99484 (MGI:3045614|PMID:11747812) RGD PMID:11747812 MGI:3045614 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO MGI:2149329 (MGI:1353782|PMID:10683373) RGD PMID:10683373 MGI:1353782 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO MGI:3045616|MGI:88313 (MGI:3045614|PMID:11747812) RGD PMID:11747812 MGI:3045614 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Epha2 Eph receptor A2 ISO (MGI:5284750|PMID:19321667) RGD PMID:19321667 MGI:5284750 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Id2 inhibitor of DNA binding 2 ISS
ISO
GO_REF:0000024
(MGI:2446740|PMID:12456807)
UniProt
RGD
PMID:12456807 GO_REF:0000024, MGI:2446740 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO (MGI:3835718|PMID:18604197) RGD PMID:18604197 MGI:3835718 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Med1 mediator complex subunit 1 ISO MGI:3511276|MGI:4443002 (MGI:3578445|PMID:15843544), (MGI:4442276|PMID:20351249) RGD PMID:15843544, PMID:20351249 MGI:3578445, MGI:4442276 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:1888385 (MGI:5424261|PMID:22588720) RGD PMID:22588720 MGI:5424261 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO MGI:1859962 (MGI:1889907|PMID:11051546) RGD PMID:11051546 MGI:1889907 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
epithelial cell proliferation involved in mammary gland duct elongation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin ISO MGI:2176531 (MGI:3703920|PMID:17369357) RGD PMID:17369357 MGI:3703920 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Esr1 estrogen receptor 1 IEA
ISO
GO_REF:0000107
MGI:2150897 (MGI:3629536|PMID:12021201)
Ensembl
RGD
PMID:12021201 GO_REF:0000107, MGI:3629536 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Med1 mediator complex subunit 1 ISO MGI:3511276 (MGI:3576991|PMID:15647257) RGD PMID:15647257 MGI:3576991 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Tfap2c transcription factor AP-2 gamma ISO MGI:3040993 (MGI:4422106|PMID:20131354) RGD PMID:20131354 MGI:4422106 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194
JBrowse link
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
(MGI:3761053|PMID:17898001)
Ensembl
RGD
PMID:17898001 GO_REF:0000107, MGI:3761053 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
negative regulation of mammary gland epithelial cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated IEA
ISO
GO_REF:0000107
(PMID:15930293)
Ensembl
RGD
PMID:15930293 GO_REF:0000107 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO MGI:1926877 (MGI:3047035|PMID:15105443) RGD PMID:15105443 MGI:3047035 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Etv4 ETS variant transcription factor 4 ISO MGI:2445834 (MGI:3828920|PMID:18977342) RGD PMID:18977342 MGI:3828920 NCBI chr10:89,685,058...89,700,300
Ensembl chr10:89,685,058...89,700,283
JBrowse link
G Gata3 GATA binding protein 3 ISO (PMID:19483726) RGD PMID:19483726 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Phb2 prohibitin 2 ISO MGI:3574361 (MGI:3695669|PMID:17065319) RGD PMID:17065319 MGI:3695669 NCBI chr 4:157,230,769...157,235,375
Ensembl chr 4:157,230,769...157,235,367
JBrowse link
G Robo1 roundabout guidance receptor 1 ISO
IEA
(PMID:18829537)
GO_REF:0000107
RGD
Ensembl
PMID:18829537 GO_REF:0000107 NCBI chr11:9,079,291...10,146,302
Ensembl chr11:9,642,365...10,143,317
JBrowse link
positive regulation of mammary gland epithelial cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 ISO MGI:4439325|MGI:88313 (MGI:4438668|PMID:20075866) RGD PMID:20075866 MGI:4438668 NCBI chr 7:70,360,199...70,377,422
Ensembl chr 7:70,364,813...70,377,422
JBrowse link
G Ccnd1 cyclin D1 ISO MGI:3580016 (MGI:4438668|PMID:20075866) RGD PMID:20075866 MGI:4438668 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 ISO (MGI:3835718|PMID:18604197) RGD PMID:18604197 MGI:3835718 NCBI chr 2:187,447,477...187,489,630
Ensembl chr 2:187,447,501...187,489,630
JBrowse link
G Kdm5b lysine demethylase 5B ISO MGI:4329395 (MGI:5619178|PMID:24802759) RGD PMID:24802759 MGI:5619178 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357
JBrowse link
G Mst1 macrophage stimulating 1 IBA
ISO
PMID:21873635
MGI:2445230 (MGI:5614192|PMID:25049204)
RGD PMID:25049204, PMID:21873635 MGI:5614192, RGD:13792537 NCBI chr 8:116,857,716...116,862,286
Ensembl chr 8:116,857,684...116,862,423
JBrowse link
G Rreb1 ras responsive element binding protein 1 ISO (PMID:18394891) RGD PMID:18394891 NCBI chr17:27,539,137...27,718,878
Ensembl chr17:27,539,133...27,665,266
JBrowse link
G Rtn4 reticulon 4 IEA
ISO
GO_REF:0000107
(PMID:27353365)
Ensembl
RGD
PMID:27353365 GO_REF:0000107 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link
G Zfp703 zinc finger protein 703 ISO (PMID:21337521)
(MGI:4940410|PMID:21317240)
RGD PMID:21317240, PMID:21337521 MGI:4940410 NCBI chr16:69,237,857...69,242,028
Ensembl chr16:69,237,857...69,242,028
JBrowse link
regulation of mammary gland epithelial cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator IEA
ISO
GO_REF:0000107
MGI:1857429 (MGI:1337911|PMID:10363969)
Ensembl
RGD
PMID:10363969 GO_REF:0000107, MGI:1337911 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Deaf1 DEAF1 transcription factor IEA
ISO
ISS
GO_REF:0000107
(MGI:3822223|PMID:18826651)
GO_REF:0000024
(PMID:18826651)
Ensembl
RGD
UniProt
PMID:18826651 GO_REF:0000024, GO_REF:0000107, MGI:3822223 NCBI chr 1:214,283,787...214,317,466
Ensembl chr 1:214,283,790...214,317,466
JBrowse link
G Gpx1 glutathione peroxidase 1 ISO
IEA
(PMID:16945136)
GO_REF:0000107
RGD
Ensembl
PMID:16945136 GO_REF:0000107 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hoxa5 homeo box A5 ISO MGI:2150397 (MGI:3624927|PMID:16607641) RGD PMID:16607641 MGI:3624927
G Pygo2 pygopus family PHD finger 2 ISO MGI:3711738 (MGI:4821247|PMID:19487454) RGD PMID:19487454 MGI:4821247 NCBI chr 2:188,757,167...188,762,285
Ensembl chr 2:188,757,489...188,762,282
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cell population proliferation 2156
        epithelial cell proliferation 470
          mammary gland epithelial cell proliferation 32
            epithelial cell proliferation involved in mammary gland bud elongation + 0
            epithelial cell proliferation involved in mammary gland duct elongation 5
            negative regulation of mammary gland epithelial cell proliferation 6
            positive regulation of mammary gland epithelial cell proliferation 8
            regulation of mammary gland epithelial cell proliferation + 19
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            animal organ development 4033
              gland development 664
                mammary gland development 208
                  mammary gland epithelium development 84
                    mammary gland epithelial cell proliferation 32
                      epithelial cell proliferation involved in mammary gland bud elongation + 0
                      epithelial cell proliferation involved in mammary gland duct elongation 5
                      negative regulation of mammary gland epithelial cell proliferation 6
                      positive regulation of mammary gland epithelial cell proliferation 8
                      regulation of mammary gland epithelial cell proliferation + 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.