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ONTOLOGY REPORT - ANNOTATIONS


Term:integrin activation
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Accession:GO:0033622 term browser browse the term
Definition:The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
Synonyms:exact_synonym: integrin complex activation;   integrin complex assembly


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integrin activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col16a1 collagen type XVI alpha 1 chain ISO (PMID:16754661) RGD PMID:16754661 NCBI chr 5:148,257,030...148,311,645
Ensembl chr 5:148,257,642...148,311,645
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23125415)
Ensembl
UniProt
RGD
PMID:23125415 GO_REF:0000024, GO_REF:0000107 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO (PMID:29301984) RGD PMID:29301984 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Fermt2 fermitin family member 2 ISO (PMID:22030399)
(MGI:MGI:3789779|PMID:18483218)
RGD PMID:18483218, PMID:22030399 MGI:MGI:3789779 NCBI chr15:19,807,806...19,876,557
Ensembl chr15:19,807,808...19,876,408
JBrowse link
G Fermt3 fermitin family member 3 ISO
IBA
(PMID:19234460), (PMID:19234463)
PMID:21873635
(MGI:MGI:3783912|PMID:18278053), (MGI:MGI:3838441|PMID:19234461)
RGD PMID:18278053, PMID:19234460, PMID:19234461, PMID:19234463, PMID:21873635 MGI:MGI:3783912, MGI:MGI:3838441, RGD:13792537 NCBI chr 1:222,254,183...222,272,775
Ensembl chr 1:222,254,184...222,272,285
JBrowse link
G Fn1 fibronectin 1 IEA
ISO
GO_REF:0000107
(PMID:24658351)
Ensembl
RGD
PMID:24658351 GO_REF:0000107 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO (MGI:MGI:5486544|PMID:18227284) RGD PMID:18227284 MGI:MGI:5486544 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Mzb1 marginal zone B and B1 cell-specific protein ISO
ISS
(MGI:MGI:4866969|PMID:21093319)
GO_REF:0000024
RGD
UniProt
PMID:21093319 GO_REF:0000024, MGI:MGI:4866969 NCBI chr18:28,436,546...28,438,607
Ensembl chr18:28,436,548...28,438,654
JBrowse link
G Tln1 talin 1 ISO (MGI:MGI:4439219|PMID:20150896) RGD PMID:20150896 MGI:MGI:4439219 NCBI chr 5:59,033,635...59,063,592
Ensembl chr 5:59,033,636...59,063,592
JBrowse link
negative regulation of integrin activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jam3 junctional adhesion molecule 3 ISO (PMID:19461049) RGD PMID:19461049 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
JBrowse link
G Kif14 kinesin family member 14 ISO (PMID:23209302) RGD PMID:23209302 NCBI chr13:53,350,073...53,421,992
Ensembl chr13:53,351,717...53,420,111
JBrowse link
G Ptger4 prostaglandin E receptor 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:21681739)
Ensembl
UniProt
RGD
PMID:21681739 GO_REF:0000024, GO_REF:0000107 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
positive regulation of integrin activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule ISO MGI:MGI:2179996 (MGI:MGI:3757613|PMID:10601245), (MGI:MGI:3757620|PMID:7534304) RGD PMID:7534304, PMID:10601245 MGI:MGI:3757613, MGI:MGI:3757620 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 ISO (MGI:MGI:3702377|PMID:15972452) RGD PMID:15972452 MGI:MGI:3702377 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 IMP RGD PMID:14970114 RGD:11556214 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:20016066)
Ensembl
UniProt
RGD
PMID:20016066 GO_REF:0000024, GO_REF:0000107 NCBI chr19:55,305,494...55,367,680
Ensembl chr19:55,305,496...55,367,353
JBrowse link
G Plek pleckstrin ISO (MGI:MGI:3844782|PMID:19190246) RGD PMID:19190246 MGI:MGI:3844782 NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family ISO (PMID:19461049) RGD PMID:19461049 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990
JBrowse link
G Rasip1 Ras interacting protein 1 ISO (PMID:26780829) RGD PMID:26780829 NCBI chr 1:101,609,209...101,621,648
Ensembl chr 1:101,610,773...101,621,646
JBrowse link
G Skap1 src kinase associated phosphoprotein 1 ISO (PMID:12652296) RGD PMID:12652296 NCBI chr10:84,309,379...84,619,051
Ensembl chr10:84,309,430...84,619,050
JBrowse link
positive regulation of integrin activation by cell surface receptor linked signal transduction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh17 cadherin 17 ISO (PMID:25336636) RGD PMID:25336636 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G P2ry12 purinergic receptor P2Y12 IDA PMID:20091784 ARUK-UCL PMID:20091784 RGD:6480646 NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
JBrowse link
regulation of integrin activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 ISO (MGI:MGI:4844210|PMID:20702777) RGD PMID:20702777 MGI:MGI:4844210 NCBI chr 9:100,660,366...100,767,940
Ensembl chr 9:100,660,394...100,767,940
JBrowse link
G Fblim1 filamin binding LIM protein 1 ISO (PMID:19074766) RGD PMID:19074766 NCBI chr 5:160,122,466...160,158,921
Ensembl chr 5:160,122,425...160,158,386
JBrowse link
G Selp selectin P IEA
ISO
GO_REF:0000107
(PMID:17632516)
Ensembl
RGD
PMID:17632516 GO_REF:0000107 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cellular component organization or biogenesis 6766
        cellular component organization 6510
          cellular component assembly 2967
            protein-containing complex assembly 1603
              integrin activation 25
                negative regulation of integrin activation 3
                positive regulation of integrin activation + 10
                regulation of integrin activation + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.