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ONTOLOGY REPORT - ANNOTATIONS


Term:3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
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Accession:GO:0033989 term browser browse the term
Definition:Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O.
Synonyms:broad_synonym: D-3-hydroxyacyl-CoA dehydratase activity
 related_synonym: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity;   (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity;   46 kDa hydratase 2 activity
 xref: EC:4.2.1.107;   MetaCyc:4.2.1.107-RXN;   RHEA:18933;   reactome:R-HSA-192331 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA";   reactome:R-HSA-193535 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA"


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3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
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  molecular_function 20457
    catalytic activity 6065
      lyase activity 212
        carbon-oxygen lyase activity 92
          hydro-lyase activity 71
            3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.