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ONTOLOGY REPORT - ANNOTATIONS


Term:VCP-NPL4-UFD1 AAA ATPase complex
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Accession:GO:0034098 term browser browse the term
Definition:A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
Synonyms:exact_synonym: p97-Ufd1-Npl4 complex
 narrow_synonym: Cdc48p-Npl4p-Ufd1p AAA ATPase complex


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VCP-NPL4-UFD1 AAA ATPase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Faf1 Fas associated factor 1 JBrowse link 5 129,370,767 129,738,393 RGD:1624291
RGD:1600115
G Faf2 Fas associated factor family member 2 JBrowse link 17 10,485,650 10,527,886 RGD:1624291
RGD:1600115
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:8554384
RGD:1624291
RGD:1600115
RGD:10047192
RGD:10047330
RGD:633500
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:1624291
RGD:13792537
G Ubxn1 UBX domain protein 1 JBrowse link 1 225,067,953 225,071,944 RGD:1624291
G Ubxn7 UBX domain protein 7 JBrowse link 11 71,662,786 71,695,031 RGD:1624291
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:633500
RGD:13792537
RGD:1624291
RGD:10047330
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:633500
RGD:13792537
RGD:1624291

Term paths to the root
Path 1
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  cellular_component 19843
    protein-containing complex 5779
      membrane protein complex 1210
        VCP-NPL4-UFD1 AAA ATPase complex 8
Path 2
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  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        intracellular organelle 12030
          intracellular membrane-bounded organelle 9976
            endoplasmic reticulum 1288
              VCP-NPL4-UFD1 AAA ATPase complex 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.