ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of GTPase activity
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Accession:GO:0034260 term browser browse the term
Definition:Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
Comment:An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
Synonyms:exact_synonym: down regulation of GTPase activity;   downregulation of GTPase activity;   negative regulation of guanosinetriphosphatase activity
 narrow_synonym: down regulation of Rab GTPase activity;   down regulation of Ras GTPase activity;   down regulation of Rho GTPase activity;   down regulation of regulation of Ran GTPase activity;   downregulation of Rab GTPase activity;   downregulation of Ras GTPase activity;   downregulation of Rho GTPase activity;   downregulation of regulation of Ran GTPase activity;   inhibition of GTPase activity;   inhibition of Rab GTPase activity;   inhibition of Ras GTPase activity;   inhibition of Rho GTPase activity;   inhibition of regulation of Ran GTPase activity;   negative regulation of Rab GTPase activity;   negative regulation of Ran GTPase activity;   negative regulation of Ras GTPase activity;   negative regulation of Rho GTPase activity
 alt_id: GO:0034259;   GO:0034261;   GO:1902264;   GO:1902881


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negative regulation of GTPase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcyap1 adenylate cyclase activating polypeptide 1 JBrowse link 9 121,705,897 121,725,736 RGD:2325307
G Amot angiomotin JBrowse link X 116,751,231 116,810,238 RGD:1624291
RGD:1600115
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 JBrowse link 5 8,666,046 8,760,458 RGD:1624291
RGD:1600115
G Arl2 ADP-ribosylation factor like GTPase 2 JBrowse link 1 221,504,150 221,516,191 RGD:1624291
RGD:1600115
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:631708
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:631708
G Bbs4 Bardet-Biedl syndrome 4 JBrowse link 8 64,115,005 64,154,432 RGD:1624291
RGD:1600115
G Bcas3 BCAS3, microtubule associated cell migration factor JBrowse link 10 72,756,548 73,271,851 RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1624291
RGD:1600115
G Dgki diacylglycerol kinase, iota JBrowse link 4 64,365,115 64,831,473 RGD:1600115
G F11r F11 receptor JBrowse link 13 89,826,272 89,850,151 RGD:1624291
RGD:1600115
G Fzd10 frizzled class receptor 10 JBrowse link 12 31,757,407 31,760,604 RGD:1624291
G Gmip Gem-interacting protein JBrowse link 16 21,349,652 21,363,412 RGD:1624291
RGD:1600115
G Gpsm1 G-protein signaling modulator 1 JBrowse link 3 3,767,394 3,794,360 RGD:1624291
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1624291
RGD:1600115
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:1624291
RGD:1600115
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
G LOC103692165 rhotekin JBrowse link 4 113,967,384 113,984,636 RGD:1600115
G Lrch1 leucine rich repeats and calponin homology domain containing 1 JBrowse link 15 56,778,738 56,970,439 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Mkks McKusick-Kaufman syndrome JBrowse link 3 129,866,542 129,885,213 RGD:1624291
RGD:1600115
G Pde6d phosphodiesterase 6D JBrowse link 9 93,562,099 93,607,061 RGD:1600115
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:7240703
G Plxnb3 plexin B3 JBrowse link X 157,015,297 157,030,147 RGD:1624291
RGD:1600115
G Ptprn2 protein tyrosine phosphatase, receptor type N2 JBrowse link 6 144,384,773 145,133,042 RGD:1625628
G Rcc2 regulator of chromosome condensation 2 JBrowse link 5 159,220,531 159,236,313 RGD:1624291
RGD:1600115
G Rdx radixin JBrowse link 8 56,570,728 56,612,851 RGD:1624291
RGD:1600115
G Rgn regucalcin JBrowse link X 1,833,484 1,848,904 RGD:9590205
G Rrp1b ribosomal RNA processing 1B JBrowse link 20 10,844,234 10,869,830 RGD:1624291
RGD:1600115
G Rtkn rhotekin JBrowse link 4 114,833,453 114,850,705 RGD:1600115
G Sh3bp4 SH3-domain binding protein 4 JBrowse link 9 96,210,750 96,288,903 RGD:1600115
RGD:1624291
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:1600115
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
RGD:1600115
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
RGD:1600115
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
RGD:1600115
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:1601406
G Ttc8 tetratricopeptide repeat domain 8 JBrowse link 6 122,920,308 122,974,525 RGD:1624291
RGD:1600115
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17896
    negative regulation of biological process 5354
      negative regulation of GTPase activity 38
Path 2
Term Annotations click to browse term
  biological_process 17896
    biological regulation 12607
      regulation of molecular function 3111
        regulation of catalytic activity 2177
          regulation of hydrolase activity 1220
            regulation of GTPase activity 407
              negative regulation of GTPase activity 38
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.