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ONTOLOGY REPORT - ANNOTATIONS


Term:response to type I interferon
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Accession:GO:0034340 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: response to type I IFN


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response to type I interferon term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon ISO (MGI:MGI:5645191|PMID:24882218) RGD PMID:24882218 MGI:MGI:5645191 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier ISO (PMID:22859821) RGD PMID:22859821 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Mx2 MX dynamin like GTPase 2 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase ISO (PMID:28753426) RGD PMID:28753426 NCBI chr 8:118,802,478...118,888,224
Ensembl chr 8:118,803,075...118,888,224
JBrowse link
G Shfl shiftless antiviral inhibitor of ribosomal frameshifting IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26735137)
Ensembl
UniProt
RGD
PMID:26735137 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:21,890,214...21,896,045
Ensembl chr 8:21,890,319...21,896,031
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO
IBA
(PMID:24075985)
PMID:21873635
RGD PMID:24075985, PMID:21873635 RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Sp100 SP100 nuclear antigen ISO (PMID:15247905), (PMID:16873258), (PMID:8810287), (PMID:9230084) RGD PMID:8810287, PMID:9230084, PMID:15247905, PMID:16873258 NCBI chr 9:92,675,103...92,718,489
Ensembl chr 9:92,681,078...92,717,929
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (MGI:MGI:5645191|PMID:24882218) RGD PMID:24882218 MGI:MGI:5645191 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
cellular response to type I interferon term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifit1bl interferon-induced protein with tetratricopeptide repeats 1B-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:252,914,684...252,959,348
Ensembl chr 1:252,914,684...252,922,486
JBrowse link
G Mx2 MX dynamin like GTPase 2 ISO (PMID:24500530) RGD PMID:24500530 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO (MGI:MGI:6103025|PMID:28835460) RGD PMID:28835460 MGI:MGI:6103025 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific ISO
IEA
MGI:MGI:3828307 (MGI:MGI:3821394|PMID:19060901)
GO_REF:0000107
RGD
Ensembl
PMID:19060901 GO_REF:0000107, MGI:MGI:3821394 NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236
JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:11,258,526...11,266,509
Ensembl chr 7:11,261,201...11,266,630
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 ISO (PMID:23386060) RGD PMID:23386060 NCBI chr16:54,899,452...54,918,616
Ensembl chr16:54,899,452...54,918,613
JBrowse link
G Dcst1 DC-STAMP domain containing 1 ISO (PMID:27782195) RGD PMID:27782195 NCBI chr 2:188,672,549...188,690,004
Ensembl chr 2:188,672,405...188,689,392
JBrowse link
G Mettl3 methyltransferase-like 3 ISO (PMID:30559377) RGD PMID:30559377 NCBI chr15:28,710,299...28,721,491
Ensembl chr15:28,710,300...28,721,127
JBrowse link
G Mmp12 matrix metallopeptidase 12 IEA
ISO
GO_REF:0000107
(MGI:MGI:5583923|PMID:24784232)
Ensembl
RGD
PMID:24784232 GO_REF:0000107, MGI:MGI:5583923 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 ISO (PMID:23399697) RGD PMID:23399697 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 ISO
IBA
(PMID:20434986)
PMID:21873635
(MGI:MGI:4454346|PMID:20434986)
RGD PMID:20434986, PMID:21873635 MGI:MGI:4454346, RGD:13792537 NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(PMID:11909529)
(MGI:MGI:3691503|PMID:11909529), (MGI:MGI:5493216|PMID:12138178)
GO_REF:0000024
RGD
UniProt
PMID:11909529, PMID:12138178 GO_REF:0000024, MGI:MGI:3691503, MGI:MGI:5493216 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 ISO (PMID:29670289)
(MGI:MGI:5521417|PMID:23972988)
RGD PMID:23972988, PMID:29670289 MGI:MGI:5521417 NCBI chr 3:153,210,829...153,250,705
Ensembl chr 3:153,210,829...153,250,641
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO MGI:MGI:3052754 (MGI:MGI:3834787|PMID:18724932) RGD PMID:18724932 MGI:MGI:3834787 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 ISO (PMID:28011935) RGD PMID:28011935 NCBI chr 7:124,472,758...124,491,004
Ensembl chr 7:124,472,758...124,491,004
JBrowse link
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 ISO (PMID:30559377) RGD PMID:30559377 NCBI chr 5:150,364,490...150,390,173
Ensembl chr 5:150,365,101...150,390,099
JBrowse link
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 ISO (MGI:MGI:6316470|PMID:30591559) RGD PMID:30591559 MGI:MGI:6316470 NCBI chr 2:100,677,388...100,711,365
Ensembl chr 2:100,677,411...100,710,417
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain ISO (PMID:21109225) RGD PMID:21109225 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon ISO (MGI:MGI:5792628|PMID:27129230) RGD PMID:27129230 MGI:MGI:5792628 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:3718275|PMID:17618271) RGD PMID:17618271 MGI:MGI:3718275 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:3718275|PMID:17618271) RGD PMID:17618271 MGI:MGI:3718275 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor ISO (MGI:MGI:5432265|PMID:22745163) RGD PMID:22745163 MGI:MGI:5432265 NCBI chr 1:90,200,866...90,246,292
Ensembl chr 1:90,200,876...90,246,297
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:16127453), (PMID:20451243) RGD PMID:16127453, PMID:20451243 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Mmp12 matrix metallopeptidase 12 IEA
ISO
GO_REF:0000107
(MGI:MGI:5583923|PMID:24784232)
Ensembl
RGD
PMID:24784232 GO_REF:0000107, MGI:MGI:5583923 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 ISO (PMID:20061403) RGD PMID:20061403 NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
JBrowse link
G Tbk1 TANK-binding kinase 1 ISO (MGI:MGI:5792628|PMID:27129230) RGD PMID:27129230 MGI:MGI:5792628 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Trim6 tripartite motif containing 6 ISO (PMID:24882218)
(MGI:MGI:5645191|PMID:24882218)
RGD PMID:24882218 MGI:MGI:5645191 NCBI chr 1:169,410,084...169,423,305
Ensembl chr 1:169,410,115...169,423,283
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO (PMID:24882218) RGD PMID:24882218 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link
G Wnt5a Wnt family member 5A ISO
IEA
(PMID:19399181)
GO_REF:0000107
RGD
Ensembl
PMID:19399181 GO_REF:0000107 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Zbp1 Z-DNA binding protein 1 ISO
IEA
IBA
(MGI:MGI:3718275|PMID:17618271)
GO_REF:0000002
PMID:21873635
RGD
InterPro
PMID:17618271, PMID:21873635 GO_REF:0000002, MGI:MGI:3718275, RGD:13792537 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537
JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO
IEA
(PMID:16280321)
GO_REF:0000107
RGD
Ensembl
PMID:16280321 GO_REF:0000107 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO (PMID:16280321) RGD PMID:16280321 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
type I interferon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07015596.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr14:65,152,594...65,153,013 JBrowse link
G AABR07021463.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr13:73,661,131...73,661,553 JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 ISO (PMID:27777077) RGD PMID:27777077 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:213,765,825...213,767,841
Ensembl chr 1:213,766,758...213,767,815
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 ISO
IBA
(MGI:MGI:4431293|PMID:20064371)
PMID:21873635
RGD PMID:20064371, PMID:21873635 MGI:MGI:4431293, RGD:13792537 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifitm6 interferon induced transmembrane protein 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:213,816,966...213,856,570
Ensembl chr 1:213,817,312...213,818,222
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 ISO (PMID:7665574)
(MGI:MGI:5562515|PMID:23872679), (MGI:MGI:5705226|PMID:14532120), (MGI:MGI:5792628|PMID:27129230)
RGD PMID:7665574, PMID:14532120, PMID:23872679, PMID:27129230 MGI:MGI:5562515, MGI:MGI:5705226, MGI:MGI:5792628 NCBI chr11:31,640,407...31,666,839
Ensembl chr11:31,640,407...31,664,061
JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 ISO
IBA
(PMID:26424569), (PMID:7665574)
PMID:21873635
RGD PMID:7665574, PMID:26424569, PMID:21873635 RGD:13792537 NCBI chr11:31,527,790...31,559,834
Ensembl chr11:31,539,016...31,558,851
JBrowse link
G Ifnb1 interferon beta 1 ISO (PMID:18035482)
(MGI:MGI:5792628|PMID:27129230)
RGD PMID:18035482, PMID:27129230 MGI:MGI:5792628 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO (PMID:23633945) RGD PMID:23633945 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:5792628|PMID:27129230) RGD PMID:27129230 MGI:MGI:5792628 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:5792628|PMID:27129230) RGD PMID:27129230 MGI:MGI:5792628 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO (PMID:23633945) RGD PMID:23633945 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 ISS
ISO
GO_REF:0000024
(MGI:MGI:6094812|PMID:29117179)
UniProt
RGD
PMID:29117179 GO_REF:0000024, MGI:MGI:6094812 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G RGD1561738 similar to interferon induced transmembrane protein 2 (1-8D) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:73,661,005...73,661,699 JBrowse link
G RGD1565332 similar to interferon induced transmembrane protein 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:65,152,594...65,153,013 JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO
IBA
(PMID:23386060)
PMID:21873635
(MGI:MGI:5493216|PMID:12138178), (MGI:MGI:5619426|PMID:24598055)
RGD PMID:12138178, PMID:23386060, PMID:24598055, PMID:21873635 MGI:MGI:5493216, MGI:MGI:5619426, RGD:13792537 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat2 signal transducer and activator of transcription 2 ISO
IBA
(MGI:MGI:5619426|PMID:24598055)
PMID:21873635
(PMID:23391734)
RGD PMID:23391734, PMID:24598055, PMID:21873635 MGI:MGI:5619426, RGD:13792537 NCBI chr 7:2,691,064...2,707,530
Ensembl chr 7:2,691,369...2,707,741
JBrowse link
G Stat4 signal transducer and activator of transcription 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO MGI:MGI:3052754 (MGI:MGI:5908297|PMID:28351661) RGD PMID:28351661 MGI:MGI:5908297 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    immune system process 2843
      immune response 1746
        innate immune response 836
          response to type I interferon 52
            cellular response to type I interferon + 47
Path 2
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to biotic stimulus 1745
        response to external biotic stimulus 1712
          response to other organism 1708
            defense response to other organism 1119
              innate immune response 836
                response to type I interferon 52
                  cellular response to type I interferon + 47
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.