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ONTOLOGY REPORT - ANNOTATIONS


Term:'de novo' NAD biosynthetic process from tryptophan
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Accession:GO:0034354 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.


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'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase IEA UniProt GO_REF:0000104 NCBI chr17:78,185,102...78,207,702
Ensembl chr17:78,187,317...78,207,701
JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:42,767,087...42,801,002
Ensembl chr 2:42,767,089...42,792,593
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:39,934,955...40,016,391
Ensembl chr 8:39,934,614...40,016,391
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProt GO_REF:0000104 NCBI chr 1:241,531,883...241,595,642
Ensembl chr 1:241,532,134...241,595,642
JBrowse link
G KYNU kynureninase IEA UniProt GO_REF:0000104 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
regulation of 'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase TAS (PMID:12140278), (PMID:19843166) ParkinsonsUK-UCL PMID:12140278, PMID:19843166 NCBI chr 2:134,838,319...134,902,906
Ensembl chr 2:134,838,616...134,902,034
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18650
    metabolic process 12284
      primary metabolic process 10996
        cellular amino acid metabolic process 363
          aromatic amino acid family metabolic process 43
            tryptophan metabolic process 13
              'de novo' NAD biosynthetic process from tryptophan 7
                negative regulation of 'de novo' NAD biosynthetic process from tryptophan 0
                positive regulation of 'de novo' NAD biosynthetic process from tryptophan 0
                regulation of 'de novo' NAD biosynthetic process from tryptophan + 1
Path 2
Term Annotations click to browse term
  biological_process 18650
    metabolic process 12284
      cellular metabolic process 11267
        cellular aromatic compound metabolic process 6226
          nucleobase-containing compound metabolic process 5975
            nucleobase-containing small molecule metabolic process 669
              nucleoside phosphate metabolic process 578
                nucleotide metabolic process 570
                  nucleotide biosynthetic process 286
                    pyridine nucleotide biosynthetic process 33
                      nicotinamide nucleotide biosynthetic process 33
                        NAD biosynthetic process 29
                          'de novo' NAD biosynthetic process 7
                            'de novo' NAD biosynthetic process from tryptophan 7
                              negative regulation of 'de novo' NAD biosynthetic process from tryptophan 0
                              positive regulation of 'de novo' NAD biosynthetic process from tryptophan 0
                              regulation of 'de novo' NAD biosynthetic process from tryptophan + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.