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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular response to heat
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Accession:GO:0034605 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
Synonyms:exact_synonym: cellular response to heat stress


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cellular response to heat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07037960.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr  X:36,277,640...36,280,461 JBrowse link
G Ano1 anoctamin 1 ISO (MGI:MGI:5461590|PMID:22634729) RGD PMID:22634729 MGI:MGI:5461590 NCBI chr 1:217,754,349...217,902,540
Ensembl chr 1:217,754,336...217,902,473
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr 8:120,323,895...120,492,790
Ensembl chr 8:120,323,897...120,446,507
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEP RGD PMID:10748035 RGD:10047286 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atxn3 ataxin 3 ISO (MGI:MGI:4413539|PMID:19843543) RGD PMID:19843543 MGI:MGI:4413539 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461
JBrowse link
G Bag3 BAG cochaperone 3 ISO (PMID:26159920) RGD PMID:26159920 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEP RGD PMID:11295070 RGD:8547793 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cetn1 centrin 1 ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr18:785,972...786,674
Ensembl chr18:785,972...786,674
JBrowse link
G Cftr CF transmembrane conductance regulator IEP RGD PMID:22777528 RGD:11567213 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clpb caseinolytic mitochondrial matrix peptidase chaperone subunit B IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:2745427)
Ensembl
RGD
PMID:2745427, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:166,739,372...166,866,095
Ensembl chr 1:166,739,532...166,866,107
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP RGD PMID:17457469 RGD:2311382 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Daxx death-domain associated protein ISO
IEA
ISS
(PMID:15016915)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15016915 GO_REF:0000024, GO_REF:0000107 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Dhx36 DEAH-box helicase 36 ISO (PMID:18854321) RGD PMID:18854321 NCBI chr 2:152,785,844...152,824,549
Ensembl chr 2:152,785,844...152,824,547
JBrowse link
G Dhx9 DExH-box helicase 9 ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha IDA
IEP
RGD PMID:7930798, PMID:3500171 RGD:10395354, RGD:10395357 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO
ISS
(PMID:12746488)
GO_REF:0000024
RGD
UniProt
PMID:12746488 GO_REF:0000024 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Hdac2 histone deacetylase 2 IEP RGD PMID:18849323 RGD:2306446 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hikeshi heat shock protein nuclear import factor IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:22541429)
Ensembl
UniProt
RGD
PMID:22541429 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:154,147,098...154,170,429
Ensembl chr 1:154,142,836...154,170,409
JBrowse link
G Hmox1 heme oxygenase 1 ISO (PMID:21597468) RGD PMID:21597468 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 IMP
ISO
(PMID:10359787), (PMID:10413683), (PMID:10747973), (PMID:11514557), (PMID:11583998), (PMID:12917326), (PMID:14707147), (PMID:16554823), (PMID:17897941), (PMID:21085490), (PMID:26159920), (PMID:7935471), (PMID:8455624), (PMID:9222587), (PMID:9341107), (PMID:9727490) RGD PMID:7935471, PMID:8455624, PMID:9222587, PMID:9341107, PMID:9727490, PMID:10359787, PMID:10413683, PMID:10747973, PMID:11514557, PMID:11583998, PMID:12917326, PMID:14707147, PMID:16554823, PMID:17897941, PMID:21085490, PMID:26159920, PMID:21779805 RGD:10402942 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO
IBA
(MGI:MGI:6316406|PMID:27496612)
PMID:21873635
RGD PMID:27496612, PMID:21873635 MGI:MGI:6316406, RGD:13792537 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO
IBA
(MGI:MGI:6316406|PMID:27496612)
PMID:21873635
RGD PMID:27496612, PMID:21873635 MGI:MGI:6316406, RGD:13792537 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO (PMID:24061851) RGD PMID:24061851 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO (PMID:24061851) RGD PMID:24061851 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IEP RGD PMID:8955942 RGD:10059375 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP RGD PMID:24065656 RGD:12910540 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Htra2 HtrA serine peptidase 2 ISO (PMID:10971580) RGD PMID:10971580 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Ier5 immediate early response 5 ISO (PMID:25816751) RGD PMID:25816751 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303
JBrowse link
G Il1a interleukin 1 alpha IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:12746488)
Ensembl
UniProt
RGD
PMID:12746488 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 IDA RGD PMID:23324889 RGD:7495799 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G LOC103692716 heat shock protein HSP 90-alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:135,044,833...135,050,417
Ensembl chr 6:135,045,363...135,049,728
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IEP RGD PMID:12372808 RGD:2303719 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mki67 marker of proliferation Ki-67 IEP RGD PMID:9631633 RGD:2317714 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Myof myoferlin ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr 1:256,585,410...256,734,727
Ensembl chr 1:256,585,410...256,734,730
JBrowse link
G Nf1 neurofibromin 1 ISO
IEA
(MGI:MGI:4821029|PMID:20661302)
GO_REF:0000107
RGD
Ensembl
PMID:20661302 GO_REF:0000107, MGI:MGI:4821029 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nos3 nitric oxide synthase 3 IEP RGD PMID:15475520 RGD:5132625 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pdcd6 programmed cell death 6 ISO (PMID:21122810) RGD PMID:21122810 NCBI chr 1:31,576,183...31,591,852
Ensembl chr 1:31,576,183...31,591,849
JBrowse link
G Pdcl3 phosducin-like 3 IDA PMID:27496612 UniProt PMID:27496612 RGD:14695071 NCBI chr 9:45,672,257...45,680,728
Ensembl chr 9:45,672,157...45,680,799
JBrowse link
G Pmp22 peripheral myelin protein 22 ISO MGI:MGI:1856217 (MGI:MGI:5517729|PMID:23847051) RGD PMID:23847051 MGI:MGI:5517729 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO
IEA
ISS
(PMID:21085490)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:21085490 GO_REF:0000024, GO_REF:0000107 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP RGD PMID:22777528 RGD:11567213 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rasa3 RAS p21 protein activator 3 IDA PMID:7500386 MGI PMID:7500386 RGD:10047323 NCBI chr16:81,320,090...81,434,239
Ensembl chr16:81,318,633...81,434,363
JBrowse link
G Scara5 scavenger receptor class A, member 5 ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr15:49,069,142...49,177,159
Ensembl chr15:49,069,145...49,177,166
JBrowse link
G Slc52a3 solute carrier family 52 member 3 ISO
IEA
(MGI:MGI:3821682|PMID:18755693)
GO_REF:0000107
RGD
Ensembl
PMID:18755693 GO_REF:0000107, MGI:MGI:3821682 NCBI chr 3:147,503,266...147,517,935
Ensembl chr 3:147,511,406...147,516,455
JBrowse link
G Slu7 SLU7 homolog, splicing factor ISO
ISS
(PMID:21122810)
GO_REF:0000024
RGD
UniProt
PMID:21122810 GO_REF:0000024 NCBI chr10:29,029,556...29,044,919
Ensembl chr10:29,029,590...29,044,583
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr 4:177,065,266...177,195,942
Ensembl chr 4:177,065,168...177,196,180
JBrowse link
G Stac SH3 and cysteine rich domain ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr 8:119,820,664...119,941,867
Ensembl chr 8:119,821,901...119,889,661
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 IDA PMID:19953350 ARUK-UCL PMID:19953350 RGD:13507303 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 ISO
ISS
(PMID:11514557)
GO_REF:0000024
RGD
UniProt
PMID:11514557 GO_REF:0000024 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Tcim transcriptional and immune response regulator ISO (PMID:17603013) RGD PMID:17603013 NCBI chr16:72,401,526...72,403,180
Ensembl chr16:72,401,887...72,403,179
JBrowse link
G Tfec transcription factor EC ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr 4:44,063,533...44,136,815
Ensembl chr 4:44,065,045...44,136,815
JBrowse link
G Tp53 tumor protein p53 IEP RGD PMID:11295070 RGD:8547793 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO
ISS
(PMID:17897941)
GO_REF:0000024
RGD
UniProt
PMID:17897941 GO_REF:0000024 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP RGD PMID:22458587 RGD:10043621 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IDA
ISO
PMID:11226139
(PMID:11226139)
RGD PMID:11226139, PMID:11226139 RGD:11535102 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO
ISS
(MGI:MGI:5486547|PMID:18174177)
GO_REF:0000024
RGD
UniProt
PMID:18174177 GO_REF:0000024, MGI:MGI:5486547 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
G Vcp valosin-containing protein ISS
ISO
GO_REF:0000024
(PMID:29804830)
UniProt
RGD
PMID:29804830 GO_REF:0000024 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Xylt1 xylosyltransferase 1 ISO (MGI:MGI:3821682|PMID:18755693) RGD PMID:18755693 MGI:MGI:3821682 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO
ISS
(PMID:12917326)
GO_REF:0000024
RGD
UniProt
PMID:12917326 GO_REF:0000024 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link
G Zfand1 zinc finger AN1-type containing 1 NOT ISO (PMID:29804830) RGD PMID:29804830 NCBI chr 2:93,656,895...93,666,745
Ensembl chr 2:93,656,946...93,665,939
JBrowse link
G Zfp709 zinc finger protein 709 IDA PMID:17374454 UniProt PMID:17374454 RGD:8553966 NCBI chr16:19,632,954...19,643,956
Ensembl chr16:19,634,134...19,643,236
JBrowse link
cellular heat acclimation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsbp1 heat shock factor binding protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:51,985,196...51,989,528
Ensembl chr19:51,985,170...51,989,544
JBrowse link
G Hsbp1l1 heat shock factor binding protein 1-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:76,748,067...76,754,642
Ensembl chr18:76,748,067...76,753,902
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO (PMID:21231916) RGD PMID:21231916 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO (PMID:21231916) RGD PMID:21231916 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor ISO
ISS
(PMID:7503932)
GO_REF:0000024
RGD
UniProt
PMID:7503932 GO_REF:0000024 NCBI chr  X:33,648,682...33,665,821
Ensembl chr  X:33,648,682...33,665,821
JBrowse link
mRNA export from nucleus in response to heat stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polr2d RNA polymerase II subunit D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:24,570,762...24,577,894
Ensembl chr18:24,570,762...24,577,894
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO
ISS
(PMID:17897941)
GO_REF:0000024
RGD
UniProt
PMID:17897941 GO_REF:0000024 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
negative regulation of cellular response to heat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule ISO
ISS
(PMID:17505307)
GO_REF:0000024
RGD
UniProt
PMID:17505307 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
positive regulation of cellular response to heat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ier5 immediate early response 5 ISO (PMID:26496226) RGD PMID:26496226 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303
JBrowse link
positive regulation of transcription from RNA polymerase II promoter in response to heat stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsf1 heat shock transcription factor 1 ISO (PMID:10747973), (PMID:12659875), (PMID:12665592), (PMID:15016915), (PMID:25963659), (PMID:26754925), (PMID:7760831), (PMID:9499401) RGD PMID:7760831, PMID:9499401, PMID:10747973, PMID:12659875, PMID:12665592, PMID:15016915, PMID:25963659, PMID:26754925 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
regulation of cellular response to heat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chordc1 cysteine and histidine rich domain containing 1 ISO
ISS
(MGI:MGI:4837047|PMID:20493909)
GO_REF:0000024
RGD
UniProt
PMID:20493909 GO_REF:0000024, MGI:MGI:4837047 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165
JBrowse link
G Hsf1 heat shock transcription factor 1 ISO (PMID:11583998) RGD PMID:11583998 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Mapt microtubule-associated protein tau ISO
IEA
(PMID:21131359)
GO_REF:0000107
(MGI:MGI:5816445|PMID:21131359)
RGD
Ensembl
PMID:21131359 GO_REF:0000107, MGI:MGI:5816445 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to stress 4061
        response to heat 141
          cellular response to heat 68
            cellular heat acclimation 5
            heat shock-mediated polytene chromosome puffing 0
            mRNA export from nucleus in response to heat stress + 2
            negative regulation of cellular response to heat 1
            positive regulation of cellular response to heat 1
            positive regulation of transcription from RNA polymerase II promoter in response to heat stress 1
            regulation of cellular response to heat + 5
            trehalose metabolism in response to heat stress + 0
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to abiotic stimulus 1511
        response to temperature stimulus 235
          response to heat 141
            cellular response to heat 68
              cellular heat acclimation 5
              heat shock-mediated polytene chromosome puffing 0
              mRNA export from nucleus in response to heat stress + 2
              negative regulation of cellular response to heat 1
              positive regulation of cellular response to heat 1
              positive regulation of transcription from RNA polymerase II promoter in response to heat stress 1
              regulation of cellular response to heat + 5
              trehalose metabolism in response to heat stress + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.