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ONTOLOGY REPORT - ANNOTATIONS


Term:cortisol biosynthetic process
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Accession:GO:0034651 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.
Synonyms:exact_synonym: cortisol biosynthesis;   cortisol formation;   cortisol synthesis
 narrow_synonym: cortisol anabolism


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cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:4891166
RGD:1600115
RGD:1624291
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4891166
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:1624291
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:1624291
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 JBrowse link 1 176,940,424 176,983,076 RGD:1624291
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:4891166
RGD:1624291
RGD:1600115
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1600115
RGD:1624291
regulation of cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgkq diacylglycerol kinase, theta JBrowse link 14 2,069,409 2,083,370 RGD:1624291
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) JBrowse link 5 166,994,683 167,030,441 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      hormone metabolic process 236
        glucocorticoid metabolic process 25
          cortisol metabolic process 12
            cortisol biosynthetic process 11
              negative regulation of cortisol biosynthetic process 4
              positive regulation of cortisol biosynthetic process 1
              regulation of cortisol biosynthetic process + 7
Path 2
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      primary metabolic process 10411
        lipid metabolic process 1300
          lipid biosynthetic process 564
            steroid biosynthetic process 160
              steroid hormone biosynthetic process 49
                glucocorticoid biosynthetic process 17
                  cortisol biosynthetic process 11
                    negative regulation of cortisol biosynthetic process 4
                    positive regulation of cortisol biosynthetic process 1
                    regulation of cortisol biosynthetic process + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.