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ONTOLOGY REPORT - ANNOTATIONS


Term:hippo signaling
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Accession:GO:0035329 term browser browse the term
Definition:The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
Synonyms:exact_synonym: hippo signal transduction;   hippo signaling pathway
 narrow_synonym: SWH pathway;   Salvador-Warts-Hippo signaling pathway
 related_synonym: hippo signaling cascade;   hippo signalling cascade


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hippo signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amot angiomotin JBrowse link X 116,751,231 116,810,238 RGD:1624291
RGD:13792537
G Amotl1 angiomotin-like 1 JBrowse link 8 13,037,265 13,157,701 RGD:1600115
G Amotl2 angiomotin like 2 JBrowse link 8 111,210,261 111,226,217 RGD:13792537
RGD:1624291
G Dchs1 dachsous cadherin-related 1 JBrowse link 1 170,594,981 170,629,062 RGD:1624291
RGD:1600115
G Fat4 FAT atypical cadherin 4 JBrowse link 2 125,751,818 125,879,398 RGD:1624291
G Lats1 large tumor suppressor kinase 1 JBrowse link 1 1,784,078 1,817,310 RGD:1624291
RGD:13792537
G Lats2 large tumor suppressor kinase 2 JBrowse link 15 37,943,609 37,995,175 RGD:1624291
RGD:13792537
G Mob1a MOB kinase activator 1A JBrowse link 4 115,024,927 115,041,904 RGD:1624291
G Mob1b MOB kinase activator 1B JBrowse link 14 20,960,052 20,992,753 RGD:1624291
G Pja2 praja ring finger ubiquitin ligase 2 JBrowse link 9 111,998,204 112,048,847 RGD:1600115
G Sav1 salvador family WW domain containing protein 1 JBrowse link 6 92,376,470 92,398,678 RGD:1600115
RGD:13792537
RGD:1624291
G Stk3 serine/threonine kinase 3 JBrowse link 7 73,617,926 73,883,896 RGD:1624291
RGD:1600115
G Stk4 serine/threonine kinase 4 JBrowse link 3 160,467,552 160,546,540 RGD:1624291
G Tead1 TEA domain transcription factor 1 JBrowse link 1 177,495,500 177,714,795 RGD:1624291
RGD:13792537
G Tead2 TEA domain transcription factor 2 JBrowse link 1 101,213,782 101,230,483 RGD:1624291
RGD:13792537
G Tead3 TEA domain transcription factor 3 JBrowse link 20 7,911,562 7,930,949 RGD:1624291
G Tead4 TEA domain transcription factor 4 JBrowse link 4 161,542,566 161,619,848 RGD:1624291
RGD:13792537
G Wwtr1 WW domain containing transcription regulator 1 JBrowse link 2 147,577,149 147,693,033 RGD:1624291
RGD:13792537
G Yap1 Yes1 associated transcriptional regulator JBrowse link 8 6,133,014 6,204,240 RGD:1624291
RGD:13792537
negative regulation of hippo signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07002945.1 RGD:1600115
G Ajuba ajuba LIM protein JBrowse link 15 33,208,210 33,218,456 RGD:1624291
RGD:13792537
RGD:1600115
G Dlg5 discs large MAGUK scaffold protein 5 JBrowse link 15 120,213 230,312 RGD:1624291
G Limd1 LIM domains containing 1 JBrowse link 8 132,553,218 132,598,826 RGD:1624291
RGD:13792537
RGD:1600115
G Mark3 microtubule affinity regulating kinase 3 JBrowse link 6 136,040,957 136,129,780 RGD:1624291
RGD:1600115
G Wtip WT1 interacting protein JBrowse link 1 89,966,496 89,999,892 RGD:1624291
G Wwc1 WW and C2 domain containing 1 JBrowse link 10 20,662,996 20,818,500 RGD:1624291
G Wwc2 WW and C2 domain containing 2 JBrowse link 16 47,368,768 47,533,816 RGD:1624291
G Wwc3 WWC family member 3 JBrowse link X 24,872,496 24,988,671 RGD:1624291
positive regulation of hippo signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dlg5 discs large MAGUK scaffold protein 5 JBrowse link 15 120,213 230,312 RGD:1624291
G Sox11 SRY-box transcription factor 11 JBrowse link 6 46,629,967 46,631,988 RGD:1624291
RGD:1600115
regulation of hippo signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mob3b MOB kinase activator 3B JBrowse link 5 50,437,444 50,638,136 RGD:1624291
G Nek8 NIMA-related kinase 8 JBrowse link 10 65,404,489 65,439,059 RGD:1624291
G Nf2 neurofibromin 2 JBrowse link 14 84,996,905 85,088,547 RGD:1600115
RGD:1624291
G Wwc1 WW and C2 domain containing 1 JBrowse link 10 20,662,996 20,818,500 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    signaling 7456
      signal transduction 6872
        intracellular signal transduction 2584
          hippo signaling 32
            negative regulation of hippo signaling 9
            positive regulation of hippo signaling 2
            regulation of hippo signaling + 13
Path 2
Term Annotations click to browse term
  biological_process 19336
    biological regulation 13340
      regulation of biological process 12655
        regulation of cellular process 11995
          signal transduction 6872
            intracellular signal transduction 2584
              hippo signaling 32
                negative regulation of hippo signaling 9
                positive regulation of hippo signaling 2
                regulation of hippo signaling + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.