ONTOLOGY REPORT - ANNOTATIONS


Term:intracellular signal transduction
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Accession:GO:0035556 term browser browse the term
Definition:The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms:exact_synonym: intracellular signaling chain
 narrow_synonym: intracellular protein kinase cascade;   intracellular signal transduction pathway;   protein kinase cascade;   signal transmission via intracellular cascade
 related_synonym: intracellular signaling cascade;   intracellular signaling pathway;   signal transduction via intracellular signaling cascade
 alt_id: GO:0007242;   GO:0007243;   GO:0023013;   GO:0023034


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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17942
    signaling 7023
      signal transduction 6517
        intracellular signal transduction 2547
          I-kappaB kinase/NF-kappaB signaling + 211
          MAPK cascade + 838
          NIK/NF-kappaB signaling + 126
          PKR signal transduction 0
          TOR signaling + 124
          TRAF-mediated signal transduction 0
          cytoplasmic pattern recognition receptor signaling pathway + 40
          endosomal signal transduction 0
          hippo signaling + 30
          inositol lipid-mediated signaling + 168
          intracellular signal transduction involved in positive regulation of cell growth 0
          intrinsic apoptotic signaling pathway + 295
          negative regulation of intracellular signal transduction + 531
          phosphorelay signal transduction system + 0
          positive regulation of intracellular signal transduction + 978
          protein kinase A signaling + 31
          protein kinase B signaling + 195
          protein kinase C signaling + 37
          protein kinase D signaling + 4
          regulation of intracellular signal transduction + 1652
          second-messenger-mediated signaling + 461
          signal transduction by p53 class mediator + 141
          signal transduction downstream of smoothened + 4
          signal transduction in response to DNA damage + 95
          signal transduction involved in cell cycle checkpoint + 31
          signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 0
          small GTPase mediated signal transduction + 495
          stress-activated protein kinase signaling cascade + 302
Path 2
Term Annotations click to browse term
  biological_process 17942
    biological regulation 12628
      regulation of biological process 11968
        regulation of cellular process 11309
          signal transduction 6517
            intracellular signal transduction 2547
              I-kappaB kinase/NF-kappaB signaling + 211
              MAPK cascade + 838
              NIK/NF-kappaB signaling + 126
              PKR signal transduction 0
              TOR signaling + 124
              TRAF-mediated signal transduction 0
              cytoplasmic pattern recognition receptor signaling pathway + 40
              endosomal signal transduction 0
              hippo signaling + 30
              inositol lipid-mediated signaling + 168
              intracellular signal transduction involved in positive regulation of cell growth 0
              intrinsic apoptotic signaling pathway + 295
              negative regulation of intracellular signal transduction + 531
              phosphorelay signal transduction system + 0
              positive regulation of intracellular signal transduction + 978
              protein kinase A signaling + 31
              protein kinase B signaling + 195
              protein kinase C signaling + 37
              protein kinase D signaling + 4
              regulation of intracellular signal transduction + 1652
              second-messenger-mediated signaling + 461
              signal transduction by p53 class mediator + 141
              signal transduction downstream of smoothened + 4
              signal transduction in response to DNA damage + 95
              signal transduction involved in cell cycle checkpoint + 31
              signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 0
              small GTPase mediated signal transduction + 495
              stress-activated protein kinase signaling cascade + 302
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.