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ONTOLOGY REPORT - ANNOTATIONS


Term:intracellular signal transduction
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Accession:GO:0035556 term browser browse the term
Definition:The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms:exact_synonym: intracellular signaling chain
 narrow_synonym: intracellular protein kinase cascade;   intracellular signal transduction pathway;   protein kinase cascade;   signal transmission via intracellular cascade
 related_synonym: intracellular signaling cascade;   intracellular signaling pathway;   signal transduction via intracellular signaling cascade
 alt_id: GO:0007242;   GO:0007243;   GO:0023013;   GO:0023034


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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    signaling 7580
      signal transduction 7011
        intracellular signal transduction 2594
          I-kappaB kinase/NF-kappaB signaling + 273
          MAPK cascade + 831
          NIK/NF-kappaB signaling + 141
          PKR-mediated signaling 0
          RAM/MOR signaling pathway 0
          TOR signaling + 131
          TRAF-mediated signal transduction 1
          cytoplasmic pattern recognition receptor signaling pathway + 51
          endosomal signal transduction 0
          hippo signaling + 37
          inositol lipid-mediated signaling + 183
          intracellular signal transduction involved in positive regulation of cell growth 0
          intrinsic apoptotic signaling pathway + 304
          negative regulation of intracellular signal transduction + 542
          phosphorelay signal transduction system + 0
          positive regulation of intracellular signal transduction + 1055
          protein kinase A signaling + 40
          protein kinase B signaling + 215
          protein kinase C signaling + 39
          protein kinase D signaling + 4
          regulation of intracellular signal transduction + 1669
          second-messenger-mediated signaling + 467
          signal transduction by p53 class mediator + 140
          signal transduction downstream of smoothened + 4
          signal transduction in response to DNA damage + 95
          signal transduction involved in cell cycle checkpoint + 31
          signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 0
          small GTPase mediated signal transduction + 441
          stress-activated protein kinase signaling cascade + 264
Path 2
Term Annotations click to browse term
  biological_process 20028
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            intracellular signal transduction 2594
              I-kappaB kinase/NF-kappaB signaling + 273
              MAPK cascade + 831
              NIK/NF-kappaB signaling + 141
              PKR-mediated signaling 0
              RAM/MOR signaling pathway 0
              TOR signaling + 131
              TRAF-mediated signal transduction 1
              cytoplasmic pattern recognition receptor signaling pathway + 51
              endosomal signal transduction 0
              hippo signaling + 37
              inositol lipid-mediated signaling + 183
              intracellular signal transduction involved in positive regulation of cell growth 0
              intrinsic apoptotic signaling pathway + 304
              negative regulation of intracellular signal transduction + 542
              phosphorelay signal transduction system + 0
              positive regulation of intracellular signal transduction + 1055
              protein kinase A signaling + 40
              protein kinase B signaling + 215
              protein kinase C signaling + 39
              protein kinase D signaling + 4
              regulation of intracellular signal transduction + 1669
              second-messenger-mediated signaling + 467
              signal transduction by p53 class mediator + 140
              signal transduction downstream of smoothened + 4
              signal transduction in response to DNA damage + 95
              signal transduction involved in cell cycle checkpoint + 31
              signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 0
              small GTPase mediated signal transduction + 441
              stress-activated protein kinase signaling cascade + 264
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.