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ONTOLOGY REPORT - ANNOTATIONS


Term:non-canonical Wnt signaling pathway
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Accession:GO:0035567 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
Comment:This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term.
Synonyms:exact_synonym: beta-catenin-independent Wnt receptor signaling pathway;   non-canonical Wnt receptor signaling pathway;   non-canonical Wnt receptor signalling pathway;   non-canonical Wnt-activated signaling pathway


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non-canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccdc88c coiled-coil domain containing 88C JBrowse link 6 124,905,811 125,028,011 RGD:1624291
RGD:1600115
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
G Fzd6 frizzled class receptor 6 JBrowse link 7 77,898,329 77,931,034 RGD:1624291
G Fzd7 frizzled class receptor 7 JBrowse link 9 66,305,731 66,308,550 RGD:1624291
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:1624291
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:1624291
negative regulation of non-canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ift80 intraflagellar transport 80 JBrowse link 2 165,506,878 165,600,748 RGD:1624291
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
G Mir154 microRNA 154 JBrowse link 6 133,888,586 133,888,669 RGD:1624291
G Rnf213 ring finger protein 213 JBrowse link 10 108,527,351 108,626,372 RGD:1624291
RGD:13792537
G Sfrp4 secreted frizzled-related protein 4 JBrowse link 17 47,383,983 47,394,065 RGD:1600115
RGD:1624291
G Znrf3 zinc and ring finger 3 JBrowse link 14 85,527,099 85,586,294 RGD:1624291
negative regulation of planar cell polarity pathway involved in axis elongation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:1624291
non-canonical Wnt signaling pathway via JNK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
G Fzd10 frizzled class receptor 10 JBrowse link 12 31,757,407 31,760,604 RGD:1624291
G Fzd7 frizzled class receptor 7 JBrowse link 9 66,305,731 66,308,550 RGD:1624291
G Myoc myocilin JBrowse link 13 80,517,531 80,527,928 RGD:1600115
RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
non-canonical Wnt signaling pathway via MAPK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in axis elongation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in axon guidance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 JBrowse link 8 117,620,293 117,648,034 RGD:1624291
G Fzd3 frizzled class receptor 3 JBrowse link 15 48,601,259 48,670,257 RGD:1624291
G Ryk receptor-like tyrosine kinase JBrowse link 8 111,326,339 111,398,640 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1600115
RGD:1624291
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1624291
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in gastrula mediolateral intercalation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in heart morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
RGD:13792537
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
RGD:13792537
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
RGD:13792537
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:1624291
RGD:1600115
G Fzd2 frizzled class receptor 2 JBrowse link 10 90,550,147 90,552,057 RGD:1624291
RGD:1600115
G Grhl3 grainyhead-like transcription factor 3 JBrowse link 5 153,893,039 153,925,045 RGD:1624291
G Ptk7 protein tyrosine kinase 7 JBrowse link 9 16,662,588 16,729,888 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
positive regulation of non-canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:1624291
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:10448953
RGD:1624291
G Rspo1 R-spondin 1 JBrowse link 5 142,986,526 143,007,847 RGD:1624291
G Rspo3 R-spondin 3 JBrowse link 1 30,681,648 30,768,038 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1600115
RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
positive regulation of non-canonical Wnt signaling pathway via JNK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nkd1 NKD inhibitor of WNT signaling pathway 1 JBrowse link 19 19,434,720 19,509,087 RGD:1624291
positive regulation of Wnt signaling pathway, planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Ankrd6 ankyrin repeat domain 6 JBrowse link 5 48,052,610 48,167,568 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1624291
RGD:1600115
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:8554067
RGD:1600115
RGD:1624291
G Mllt3 MLLT3, super elongation complex subunit JBrowse link 5 106,103,498 106,202,559 RGD:1624291
G Nkd1 NKD inhibitor of WNT signaling pathway 1 JBrowse link 19 19,434,720 19,509,087 RGD:1624291
G Plekha4 pleckstrin homology domain containing A4 JBrowse link 1 101,517,702 101,540,802 RGD:1624291
regulation of non-canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Daam2 dishevelled associated activator of morphogenesis 2 JBrowse link 9 13,444,883 13,493,154 RGD:1624291
RGD:13792537
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:1624291
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:1624291
regulation of Wnt signaling pathway, planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dact1 dishevelled-binding antagonist of beta-catenin 1 JBrowse link 6 93,740,440 93,751,003 RGD:1624291
RGD:13792537
G Mks1 MKS transition zone complex subunit 1 JBrowse link 10 75,149,814 75,160,481 RGD:1624291
RGD:1600115
G Znrf3 zinc and ring finger 3 JBrowse link 14 85,527,099 85,586,294 RGD:1624291
Wnt signaling pathway, calcium modulating pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fzd2 frizzled class receptor 2 JBrowse link 10 90,550,147 90,552,057 RGD:727481
G Fzd4 frizzled class receptor 4 JBrowse link 1 153,589,471 153,598,376 RGD:1624291
G Ror2 receptor tyrosine kinase-like orphan receptor 2 JBrowse link 17 11,953,552 12,134,386 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1600115
RGD:1624291
Wnt signaling pathway, planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cthrc1 collagen triple helix repeat containing 1 JBrowse link 7 77,966,722 77,977,004 RGD:1624291
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
G Fzd6 frizzled class receptor 6 JBrowse link 7 77,898,329 77,931,034 RGD:1624291
G Med12 mediator complex subunit 12 JBrowse link X 71,174,653 71,197,812 RGD:1624291
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G Ror2 receptor tyrosine kinase-like orphan receptor 2 JBrowse link 17 11,953,552 12,134,386 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:8554067
RGD:1624291
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:1624291
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19337
    signaling 7456
      cell-cell signaling 1888
        cell-cell signaling by wnt 433
          Wnt signaling pathway 430
            non-canonical Wnt signaling pathway 53
              Wnt signaling pathway, calcium modulating pathway + 4
              Wnt signaling pathway, planar cell polarity pathway + 37
              Wnt signaling pathway, regulating spindle positioning 0
              negative regulation of non-canonical Wnt signaling pathway + 9
              non-canonical Wnt signaling pathway involved in heart development + 3
              non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + 1
              non-canonical Wnt signaling pathway via MAPK cascade + 7
              positive regulation of non-canonical Wnt signaling pathway + 14
              regulation of non-canonical Wnt signaling pathway + 26
Path 2
Term Annotations click to browse term
  biological_process 19337
    biological regulation 13339
      regulation of biological process 12654
        regulation of cellular process 11993
          signal transduction 6872
            cell surface receptor signaling pathway 2674
              cell surface receptor signaling pathway involved in cell-cell signaling 553
                Wnt signaling pathway 430
                  non-canonical Wnt signaling pathway 53
                    Wnt signaling pathway, calcium modulating pathway + 4
                    Wnt signaling pathway, planar cell polarity pathway + 37
                    Wnt signaling pathway, regulating spindle positioning 0
                    negative regulation of non-canonical Wnt signaling pathway + 9
                    non-canonical Wnt signaling pathway involved in heart development + 3
                    non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + 1
                    non-canonical Wnt signaling pathway via MAPK cascade + 7
                    positive regulation of non-canonical Wnt signaling pathway + 14
                    regulation of non-canonical Wnt signaling pathway + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.