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ONTOLOGY REPORT - ANNOTATIONS


Term:G protein-coupled purinergic receptor signaling pathway
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Accession:GO:0035588 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
Synonyms:exact_synonym: G-protein coupled purinergic receptor signalling pathway


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G protein-coupled adenosine receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy5 adenylate cyclase 5 IEA
ISO
GO_REF:0000107
MGI:99402 (MGI:2387279|PMID:12223546)
Ensembl
RGD
PMID:12223546 GO_REF:0000107, MGI:2387279 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adora1 adenosine A1 receptor IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor IDA
ISO
MGI:2155985|MGI:99673 (MGI:1860411|PMID:10845921), (MGI:2387279|PMID:12223546) RGD PMID:10845921, PMID:12223546, PMID:12590138 MGI:1860411, MGI:2387279, RGD:1625697 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora2b adenosine A2B receptor IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Adora3 adenosine A3 receptor IEA
ISO
GO_REF:0000002
(MGI:2664591|PMID:12817016)
InterPro
RGD
PMID:12817016 GO_REF:0000002, MGI:2664591 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Gnai2 G protein subunit alpha i2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:11923410, PMID:21873635 RGD:625670, RGD:13792537 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnat1 G protein subunit alpha transducin 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:116,433,302...116,438,038
Ensembl chr 8:116,433,302...116,438,038
JBrowse link
G LOC100911796 adenosine receptor A3-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:208,492,231...208,536,910
Ensembl chr 2:208,530,864...208,534,506
Ensembl chr 2:208,530,864...208,534,506
JBrowse link
G P2ry1 purinergic receptor P2Y1 IDA PMID:20847060 BHF-UCL PMID:20847060 RGD:8554370 NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
JBrowse link
G P2ry12 purinergic receptor P2Y12 IMP RGD PMID:12814667 RGD:6482299 NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO
IBA
(PMID:16670267)
PMID:21873635
RGD PMID:16670267, PMID:21873635 RGD:13792537 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
positive regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 IEA
ISO
GO_REF:0000107
(PMID:18940592), (PMID:22389722)
Ensembl
RGD
PMID:18940592, PMID:22389722 GO_REF:0000107 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Cntn2 contactin 2 IEA
ISO
GO_REF:0000107
MGI:2181052 (MGI:1930847|PMID:11178983)
Ensembl
RGD
PMID:11178983 GO_REF:0000107, MGI:1930847 NCBI chr13:49,280,913...49,314,061
Ensembl chr13:49,285,310...49,313,940
JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) RGD PMID:17689978 NCBI chr19:52,086,325...52,112,633
Ensembl chr19:52,086,325...52,112,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          G protein-coupled purinergic receptor signaling pathway 14
            G protein-coupled adenosine receptor signaling pathway + 14
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            cell surface receptor signaling pathway 2761
              purinergic nucleotide receptor signaling pathway 33
                G protein-coupled purinergic receptor signaling pathway 14
                  G protein-coupled adenosine receptor signaling pathway + 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.