Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:signaling adaptor activity
go back to main search page
Accession:GO:0035591 term browser browse the term
Definition:The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
Comment:A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498).
Synonyms:exact_synonym: signalling adaptor activity
 related_synonym: signaling scaffold activity


show annotations for term's descendants       view all columns           Sort by:
 
signaling adaptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Afap1l2 actin filament associated protein 1-like 2 JBrowse link 1 277,730,760 277,827,299 RGD:1600115
G Axin1 axin 1 RGD:1624291
G Blnk B-cell linker JBrowse link 1 260,187,023 260,254,490 RGD:1624291
G Cdc42se2 CDC42 small effector 2 JBrowse link 10 40,054,393 40,122,915 RGD:1600115
RGD:1624291
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1624291
RGD:1600115
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:1600115
G Fcrl2 Fc receptor-like 2 JBrowse link 2 186,594,442 186,605,115 RGD:1624291
G Hsh2d hematopoietic SH2 domain containing JBrowse link 16 19,336,400 19,349,868 RGD:13792537
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 JBrowse link 5 147,927,145 147,953,093 RGD:1624291
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 JBrowse link 5 152,964,294 152,987,286 RGD:1624291
G LOC100362023 CDC42 small effector 2-like JBrowse link 1 94,988,080 94,988,860 RGD:1600115
G Mavs mitochondrial antiviral signaling protein JBrowse link 3 123,776,147 123,790,572 RGD:1624291
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
G Sarm1 sterile alpha and TIR motif containing 1 JBrowse link 10 65,742,343 65,766,050 RGD:1600115
G Sh2b1 SH2B adaptor protein 1 JBrowse link 1 197,878,839 197,888,223 RGD:1600115
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1600115
G Sh2d2a SH2 domain containing 2A JBrowse link 2 187,218,851 187,225,000 RGD:13792537
G Sh2d4a SH2 domain containing 4A JBrowse link 16 23,084,247 23,156,825 RGD:13792537
G Sh2d4b SH2 domain containing 4B JBrowse link 16 17,611,115 17,708,387 RGD:13792537
G Sh2d7 SH2 domain containing 7 JBrowse link 8 59,110,859 59,122,974 RGD:13792537
G Sla2 Src-like-adaptor 2 JBrowse link 3 152,942,838 153,004,047 RGD:1624291
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
G Stap2 signal transducing adaptor family member 2 JBrowse link 9 11,064,605 11,070,138 RGD:1600115
G Zdhhc11 zinc finger, DHHC-type containing 11 JBrowse link 1 31,906,049 31,936,603 RGD:1624291
JAK pathway signal transduction adaptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:1600115
MAP-kinase scaffold activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akap13 A-kinase anchoring protein 13 JBrowse link 1 137,089,558 137,315,272 RGD:11059588
RGD:13792537
RGD:1600115
RGD:1624291
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:1624291
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 1 142,525,041 142,615,673 RGD:1624291
G Ksr1 kinase suppressor of ras 1 JBrowse link 10
10
66,323,704
66,346,100
66,342,469
66,482,396
RGD:1624291
G Ksr2 kinase suppressor of ras 2 JBrowse link 12 44,531,376 44,911,835 RGD:1624291
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:1600115
RGD:1624291
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:1624291
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:2298766
RGD:1624291
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:1624291
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:1624291
RGD:13792537
G Sh3rf1 SH3 domain containing ring finger 1 JBrowse link 16 32,062,425 32,227,526 RGD:1600115
RGD:1624291
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:13792537
signaling receptor complex adaptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:1624291
G Grb10 growth factor receptor bound protein 10 JBrowse link 14 92,021,851 92,122,249 RGD:1624291
G Grip1 glutamate receptor interacting protein 1 JBrowse link 7 64,672,723 64,854,939 RGD:1600115
G Grip2 glutamate receptor interacting protein 2 JBrowse link 4 123,585,184 123,636,040 RGD:1600115
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:1624291
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:1624291
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 JBrowse link 5 152,964,294 152,987,286 RGD:1624291
G LOC103690160 SH3 and multiple ankyrin repeat domains protein 2-like JBrowse link 1 215,208,591 215,246,638 RGD:13792537
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 JBrowse link 4 10,995,241 12,472,423 RGD:1600115
RGD:13792537
RGD:1624291
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:13792537
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
RGD:1600115
G Pdlim5 PDZ and LIM domain 5 JBrowse link 2 247,815,214 247,989,198 RGD:632670
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1624291
G Rgs14 regulator of G-protein signaling 14 JBrowse link 17 9,777,925 9,792,007 RGD:8554645
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
G Shank1 SH3 and multiple ankyrin repeat domains 1 JBrowse link 1 100,297,137 100,344,377 RGD:633972
RGD:13792537
G Shank2 SH3 and multiple ankyrin repeat domains 2 JBrowse link 1 217,149,156 217,593,950 RGD:13792537
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:13792537
G Sorbs1 sorbin and SH3 domain containing 1 JBrowse link 1 259,373,921 259,502,108 RGD:1624291
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:13792537
G Spata2 spermatogenesis associated 2 JBrowse link 3 164,229,211 164,239,483 RGD:1624291
synaptic receptor adaptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Homer2 homer scaffold protein 2 JBrowse link 1 143,443,300 143,535,579 RGD:1624291
G LOC103690160 SH3 and multiple ankyrin repeat domains protein 2-like JBrowse link 1 215,208,591 215,246,638 RGD:13792537
G Shank1 SH3 and multiple ankyrin repeat domains 1 JBrowse link 1 100,297,137 100,344,377 RGD:8554380
RGD:13792537
RGD:1624291
G Shank2 SH3 and multiple ankyrin repeat domains 2 JBrowse link 1 217,149,156 217,593,950 RGD:13792537
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:8554380
RGD:13792537
transmembrane receptor protein tyrosine kinase adaptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dok2 docking protein 2 JBrowse link 15 52,449,884 52,455,414 RGD:1624291
G Frs2 fibroblast growth factor receptor substrate 2 JBrowse link 7 60,128,506 60,210,482 RGD:1624291
G Gab2 GRB2-associated binding protein 2 JBrowse link 1 162,082,876 162,283,379 RGD:1624291
RGD:1600115
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:8553881
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 JBrowse link 2 94,266,104 94,277,680 RGD:625637
G Sh2b1 SH2B adaptor protein 1 JBrowse link 1 197,878,839 197,888,223 RGD:13792537
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:1624291
RGD:13792537
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:13792537
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19678
    binding 16040
      molecular adaptor activity 312
        protein-macromolecule adaptor activity 236
          signaling adaptor activity 61
            JAK pathway signal transduction adaptor activity 1
            MAP-kinase scaffold activity 12
            signaling receptor complex adaptor activity + 30
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.