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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-18-mediated signaling pathway
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Accession:GO:0035655 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-18-mediated signalling pathway


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interleukin-18-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:21321938) RGD PMID:21321938 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Il18 interleukin 18 IEA
ISO
ISS
GO_REF:0000107
(PMID:21321938), (PMID:25500532)
GO_REF:0000024
(MGI:MGI:3578455|PMID:15843532)
Ensembl
RGD
UniProt
PMID:15843532, PMID:21321938, PMID:25500532 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3578455 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il18r1 interleukin 18 receptor 1 ISO
IBA
MGI:MGI:2136765 (MGI:MGI:2136797|PMID:10227969)
PMID:21873635
(PMID:25500532)
RGD PMID:10227969, PMID:25500532, PMID:21873635 MGI:MGI:2136797, RGD:13792537 NCBI chr 9:47,184,404...47,217,403
Ensembl chr 9:47,185,443...47,219,175
JBrowse link
G Il18rap interleukin 18 receptor accessory protein ISO
IBA
MGI:MGI:3579137 (MGI:MGI:3578455|PMID:15843532)
PMID:21873635
(PMID:25500532)
RGD PMID:15843532, PMID:25500532, PMID:21873635 MGI:MGI:3578455, RGD:13792537 NCBI chr 9:47,225,543...47,255,805
Ensembl chr 9:47,225,585...47,258,503
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEA
ISO
GO_REF:0000107
(PMID:21321938)
Ensembl
RGD
PMID:21321938 GO_REF:0000107 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
positive regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ticam2 toll-like receptor adaptor molecule 2 ISO (PMID:22685567)
(MGI:MGI:5488868|PMID:22685567)
RGD PMID:22685567 MGI:MGI:5488868 NCBI chr18:40,555,106...40,572,569
Ensembl chr18:40,555,106...40,572,241
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    signaling 7580
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            interleukin-18-mediated signaling pathway 6
              negative regulation of interleukin-18-mediated signaling pathway 0
              positive regulation of interleukin-18-mediated signaling pathway 1
              regulation of interleukin-18-mediated signaling pathway + 1
Path 2
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to chemical 6342
        response to organic substance 3865
          cellular response to organic substance 2845
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                interleukin-18-mediated signaling pathway 6
                  negative regulation of interleukin-18-mediated signaling pathway 0
                  positive regulation of interleukin-18-mediated signaling pathway 1
                  regulation of interleukin-18-mediated signaling pathway + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.