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ONTOLOGY REPORT - ANNOTATIONS


Term:macrophage migration inhibitory factor signaling pathway
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Accession:GO:0035691 term browser browse the term
Definition:A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: MIF signaling pathway;   macrophage migration inhibitory factor signalling pathway


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macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule ISO
ISS
(MGI:MGI:4943655|PMID:19413900)
GO_REF:0000024
RGD
BHF-UCL
PMID:19413900 GO_REF:0000024, MGI:MGI:4943655 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
positive regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule ISO (PMID:19665027) RGD PMID:19665027 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO (PMID:19665027) RGD PMID:19665027 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 ISO
IEA
(MGI:MGI:4437182|PMID:20060382)
GO_REF:0000107
RGD
Ensembl
PMID:20060382 GO_REF:0000107, MGI:MGI:4437182 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            macrophage migration inhibitory factor signaling pathway 3
              negative regulation of macrophage migration inhibitory factor signaling pathway 0
              positive regulation of macrophage migration inhibitory factor signaling pathway 2
              regulation of macrophage migration inhibitory factor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to chemical 6343
        response to organic substance 3865
          cellular response to organic substance 2845
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                macrophage migration inhibitory factor signaling pathway 3
                  negative regulation of macrophage migration inhibitory factor signaling pathway 0
                  positive regulation of macrophage migration inhibitory factor signaling pathway 2
                  regulation of macrophage migration inhibitory factor signaling pathway + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.