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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-4-mediated signaling pathway
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Accession:GO:0035771 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-4-mediated signaling pathway;   interleukin-4-mediated signalling pathway


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interleukin-4-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak3 Janus kinase 3 ISO
IEA
(PMID:7538655)
GO_REF:0000107
(PMID:24280217)
RGD
Ensembl
PMID:7538655, PMID:24280217 GO_REF:0000107 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO (PMID:17210636)
(MGI:5493214|PMID:17210636)
(PMID:24280217)
RGD PMID:17210636, PMID:24280217 MGI:5493214 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
negative regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(PMID:17210636)
(MGI:5493214|PMID:17210636)
GO_REF:0000024
RGD
UniProt
PMID:17210636 GO_REF:0000024, MGI:5493214 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
positive regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300lf Cd300 molecule-like family member F ISS
ISO
GO_REF:0000024
(MGI:5660125|PMID:26124135)
UniProt
RGD
PMID:26124135 GO_REF:0000024, MGI:5660125 NCBI chr10:103,669,781...103,690,584
Ensembl chr10:103,670,028...103,687,425
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 ISO (PMID:27796300)
(MGI:5905929|PMID:27796300)
RGD PMID:27796300 MGI:5905929 NCBI chr11:68,105,442...68,137,509
Ensembl chr11:68,105,369...68,137,535
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            interleukin-4-mediated signaling pathway 5
              negative regulation of interleukin-4-mediated signaling pathway 1
              positive regulation of interleukin-4-mediated signaling pathway 2
              regulation of interleukin-4-mediated signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to chemical 6337
        response to organic substance 3864
          cellular response to organic substance 2844
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                interleukin-4-mediated signaling pathway 5
                  negative regulation of interleukin-4-mediated signaling pathway 1
                  positive regulation of interleukin-4-mediated signaling pathway 2
                  regulation of interleukin-4-mediated signaling pathway + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.