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ONTOLOGY REPORT - ANNOTATIONS


Term:aldosterone secretion
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Accession:GO:0035932 term browser browse the term
Definition:The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


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aldosterone secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:1566502 RGD:6903876 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
positive regulation of aldosterone secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 IDA RGD PMID:22538126 RGD:7242193 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G C1qtnf1 C1q and TNF related 1 IEA
ISO
GO_REF:0000107
(PMID:18171693)
Ensembl
RGD
PMID:18171693 GO_REF:0000107 NCBI chr10:107,455,845...107,477,160
Ensembl chr10:107,455,845...107,477,162
JBrowse link
G Dab2 DAB adaptor protein 2 IDA RGD PMID:17303656 RGD:7243836 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
renin-angiotensin regulation of aldosterone production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA
ISO
MGI:2136636 (MGI:1332965|PMID:10076178), (MGI:2385818|PMID:9852267) RGD PMID:9852267, PMID:10076178, PMID:21318332 MGI:1332965, MGI:2385818, RGD:5129178 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP
ISO
MGI:1857147 (MGI:2386466|PMID:12167595) RGD PMID:12167595, PMID:21318332 MGI:2386466, RGD:5129178 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:21318332 RGD:5129178 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Ren renin ISO (MGI:3848759|PMID:19293336) RGD PMID:19293336 MGI:3848759 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      export from cell 1006
        lipid export from cell 95
          steroid hormone secretion 28
            corticosteroid hormone secretion 20
              mineralocorticoid secretion 7
                aldosterone secretion 7
                  negative regulation of aldosterone secretion 0
                  positive regulation of aldosterone secretion 3
                  regulation of aldosterone secretion + 7
Path 2
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          export from cell 1006
            secretion by cell 955
              signal release 617
                hormone secretion 389
                  endocrine hormone secretion 66
                    steroid hormone secretion 28
                      corticosteroid hormone secretion 20
                        mineralocorticoid secretion 7
                          aldosterone secretion 7
                            negative regulation of aldosterone secretion 0
                            positive regulation of aldosterone secretion 3
                            regulation of aldosterone secretion + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.