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ONTOLOGY REPORT - ANNOTATIONS


Term:senescence-associated heterochromatin focus assembly
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Accession:GO:0035986 term browser browse the term
Definition:The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes.
Synonyms:exact_synonym: SAHF formation;   senescence-associated heterochromatin foci formation;   senescence-associated heterochromatin focus formation


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senescence-associated heterochromatin focus assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Hmga1 high mobility group AT-hook 1 JBrowse link 20 7,132,501 7,140,155 RGD:1624291
RGD:1600115
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115

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  biological_process 19858
    cellular process 18618
      cellular component organization or biogenesis 6706
        cellular component organization 6456
          chromatin organization 834
            chromatin remodeling 216
              heterochromatin assembly 52
                senescence-associated heterochromatin focus assembly 3
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        cellular aromatic compound metabolic process 5567
          nucleobase-containing compound metabolic process 5344
            nucleic acid metabolic process 4850
              RNA metabolic process 4347
                regulation of RNA metabolic process 3510
                  negative regulation of RNA metabolic process 1418
                    negative regulation of RNA biosynthetic process 1316
                      negative regulation of nucleic acid-templated transcription 1314
                        negative regulation of transcription, DNA-templated 1280
                          chromatin organization involved in negative regulation of transcription 130
                            heterochromatin assembly 52
                              senescence-associated heterochromatin focus assembly 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.