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ONTOLOGY REPORT - ANNOTATIONS


Term:endodermal cell differentiation
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Accession:GO:0035987 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
Synonyms:exact_synonym: endoderm cell differentiation


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endodermal cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col11a1 collagen, type XI, alpha 1 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 3:114,030,479...114,220,756
Ensembl chr 3:114,030,540...114,220,718
JBrowse link
G Col12a1 collagen, type XII, alpha 1 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:79,598,987...79,721,141
Ensembl chr 9:79,598,991...79,718,831
JBrowse link
G Col4a2 collagen, type IV, alpha 2 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 8:11,312,805...11,449,287
Ensembl chr 8:11,312,805...11,449,287
JBrowse link
G Col6a1 collagen, type VI, alpha 1 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr10:76,708,792...76,726,044
Ensembl chr10:76,708,792...76,726,168
JBrowse link
G Col7a1 collagen, type VII, alpha 1 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 9:108,953,586...108,984,875
Ensembl chr 9:108,953,586...108,984,875
JBrowse link
G Col8a1 collagen, type VIII, alpha 1 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr16:57,624,256...57,754,737
Ensembl chr16:57,624,258...57,754,737
JBrowse link
G Fn1 fibronectin 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Gata6 GATA binding protein 6 IMP (MGI:1315079|PMID:9832509) MGI PMID:9832509 MGI:1315079 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO (PMID:17624332) UniProtKB PMID:17624332 NCBI chr10:120,361,268...120,476,469
Ensembl chr10:120,361,275...120,476,469
JBrowse link
G Hsbp1 heat shock factor binding protein 1 IMP (MGI:5553204|PMID:24380799) MGI PMID:24380799 MGI:5553204 NCBI chr 8:119,344,538...119,348,929
Ensembl chr 8:119,344,488...119,348,922
JBrowse link
G Inhba inhibin beta-A ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr13:16,004,256...16,031,609
Ensembl chr13:16,011,851...16,031,621
JBrowse link
G Itga4 integrin alpha 4 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 2:79,255,426...79,333,114
Ensembl chr 2:79,255,426...79,333,123
JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr15:103,344,286...103,366,791
Ensembl chr15:103,344,286...103,366,763
JBrowse link
G Itga7 integrin alpha 7 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr10:128,933,421...128,958,286
Ensembl chr10:128,933,818...128,958,282
JBrowse link
G Itgav integrin alpha V ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:83,722,303...83,806,917
Ensembl chr 2:83,724,397...83,806,916
JBrowse link
G Itgb2 integrin beta 2 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Itgb5 integrin beta 5 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr16:33,829,665...33,949,338
Ensembl chr16:33,829,665...33,949,338
JBrowse link
G Lama3 laminin, alpha 3 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr18:12,333,417...12,583,013
Ensembl chr18:12,333,819...12,583,013
JBrowse link
G Lamb1 laminin B1 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr12:31,265,146...31,329,644
Ensembl chr12:31,265,234...31,329,644
JBrowse link
G Lamb3 laminin, beta 3 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 1:193,294,353...193,343,878
Ensembl chr 1:193,207,699...193,343,878
JBrowse link
G Mixl1 Mix1 homeobox-like 1 (Xenopus laevis) IDA (MGI:5447921|PMID:19038793) BHF-UCL PMID:19038793 MGI:5447921 NCBI chr 1:180,693,043...180,697,034
Ensembl chr 1:180,693,043...180,697,034
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364
JBrowse link
G Mmp15 matrix metallopeptidase 15 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 8:95,352,296...95,374,293
Ensembl chr 8:95,352,268...95,375,080
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 9:7,558,429...7,568,486
Ensembl chr 9:7,558,456...7,568,485
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO (PMID:23154389) UniProtKB PMID:23154389 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Nodal nodal ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr10:61,417,972...61,425,338
Ensembl chr10:61,417,972...61,425,338
JBrowse link
G Setd2 SET domain containing 2 IMP (MGI:5908786|PMID:25242323) UniProt PMID:25242323 MGI:5908786 NCBI chr 9:110,532,500...110,618,633
Ensembl chr 9:110,532,597...110,618,633
JBrowse link
G Vtn vitronectin ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr11:78,499,120...78,502,325
Ensembl chr11:78,499,091...78,502,324
JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component IMP (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chr 1:143,603,276...143,702,893
Ensembl chr 1:143,598,800...143,702,893
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 IMP (MGI:3625553|PMID:12194849) MGI PMID:12194849 MGI:3625553 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component IMP (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chr 7:111,028,951...111,056,377
Ensembl chr 7:111,028,951...111,056,377
JBrowse link
G Leo1 Leo1, Paf1/RNA polymerase II complex component IMP (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chr 9:75,441,015...75,466,432
Ensembl chr 9:75,441,524...75,466,432
JBrowse link
G Paf1 Paf1, RNA polymerase II complex component IMP (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chr 7:28,392,996...28,399,383
Ensembl chr 7:28,392,951...28,399,388
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 IDA (MGI:1355046|PMID:10742100) MGI PMID:10742100 MGI:1355046 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772
JBrowse link
G Rtf1 RTF1, Paf1/RNA polymerase II complex component IMP (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chr 2:119,675,068...119,735,407
Ensembl chr 2:119,675,068...119,735,407
JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 IDA (MGI:4442295|PMID:20308546) MGI PMID:20308546 MGI:4442295 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 IDA (MGI:4442295|PMID:20308546) MGI PMID:20308546 MGI:4442295 NCBI chr 1:4,490,928...4,497,426
Ensembl chr 1:4,490,931...4,497,354
JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin IBA
IMP
(MGI:6201960|PMID:21873635)
(MGI:4887279|PMID:21245162)
GO_Central
MGI
PMID:21245162, PMID:21873635 MGI:4887279, MGI:6201960 NCBI chr 9:118,478,186...118,486,132
Ensembl chr 9:118,478,212...118,486,132
JBrowse link
G Hnf1b HNF1 homeobox B IMP (MGI:3807614|PMID:18635606) MGI PMID:18635606 MGI:3807614 NCBI chr11:83,850,209...83,905,917
Ensembl chr11:83,850,063...83,905,819
JBrowse link
G Nanog Nanog homeobox ISO (MGI:4887279|PMID:21245162) MGI PMID:21245162 MGI:4887279 NCBI chr 6:122,707,489...122,714,633
Ensembl chr 6:122,707,489...122,714,633
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 ISO (MGI:4887279|PMID:21245162) MGI PMID:21245162 MGI:4887279 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 ISO (MGI:4887279|PMID:21245162) MGI PMID:21245162 MGI:4887279 NCBI chr 3:34,649,995...34,652,461
Ensembl chr 3:34,650,405...34,652,461
JBrowse link
negative regulation of endodermal cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col5a1 collagen, type V, alpha 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:27,886,381...28,039,510
Ensembl chr 2:27,886,425...28,039,514
JBrowse link
G Col5a2 collagen, type V, alpha 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:45,374,331...45,503,282
Ensembl chr 1:45,374,321...45,503,282
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior 1 IDA (MGI:4441249|PMID:18593560) BHF-UCL PMID:18593560 MGI:4441249 NCBI chr 7:79,792,241...79,793,590
Ensembl chr 7:79,792,241...79,793,788
JBrowse link
G Nanog Nanog homeobox TAS (MGI:3690198|PMID:16501172) HGNC-UCL PMID:16501172 MGI:3690198 NCBI chr 6:122,707,489...122,714,633
Ensembl chr 6:122,707,489...122,714,633
JBrowse link
positive regulation of endodermal cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Macroh2a1 macroH2A.1 histone ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr13:56,073,622...56,135,626
Ensembl chr13:56,073,619...56,136,361
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr19:30,545,876...30,549,496
Ensembl chr19:30,545,863...30,549,665
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    cellular process 17420
      cellular developmental process 4666
        cell differentiation 4559
          endodermal cell differentiation 46
            endodermal cell fate commitment + 15
            negative regulation of endodermal cell differentiation + 4
            positive regulation of endodermal cell differentiation 1
            regulation of endodermal cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 23386
    developmental process 7030
      anatomical structure development 6504
        multicellular organism development 5968
          embryo development 1302
            embryonic morphogenesis 679
              gastrulation 202
                formation of primary germ layer 127
                  endoderm formation 56
                    endodermal cell differentiation 46
                      endodermal cell fate commitment + 15
                      negative regulation of endodermal cell differentiation + 4
                      positive regulation of endodermal cell differentiation 1
                      regulation of endodermal cell differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.