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ONTOLOGY REPORT - ANNOTATIONS


Term:tendon cell differentiation
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Accession:GO:0035990 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.
Synonyms:exact_synonym: muscle attachment cell differentiation
 related_synonym: tenocyte differentiation


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tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 IEA Ensembl GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
G MKX mohawk homeobox ISO (MGI:5287220|PMID:20696843) MGI PMID:20696843 MGI:5287220 NCBI chr 2:5,898,155...5,964,577 JBrowse link
G SCX scleraxis bHLH transcription factor ISS UniProt GO_REF:0000024 NCBI chr13:37,701,781...37,704,949
Ensembl chr13:37,703,232...37,704,657
JBrowse link
G TNMD tenomodulin ISO PMID:21412429 UniProt PMID:21412429 RGD:8553701 NCBI chr  X:74,459,111...74,475,010
Ensembl chr  X:74,459,313...74,478,170
JBrowse link
positive regulation of tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDF7 growth differentiation factor 7 ISO (MGI:5294519|PMID:21412429) UniProt PMID:21412429 MGI:5294519 NCBI chr17:15,627,739...15,636,513 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16190
    cellular process 15467
      cellular developmental process 4137
        cell differentiation 4043
          tendon cell differentiation 5
            negative regulation of tendon cell differentiation 0
            positive regulation of tendon cell differentiation 1
            regulation of tendon cell differentiation + 1
Path 2
Term Annotations click to browse term
  biological_process 16190
    developmental process 6310
      anatomical structure development 5858
        tissue development 2019
          connective tissue development 297
            tendon development 8
              tendon formation 5
                tendon cell differentiation 5
                  negative regulation of tendon cell differentiation 0
                  positive regulation of tendon cell differentiation 1
                  regulation of tendon cell differentiation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.