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ONTOLOGY REPORT - ANNOTATIONS


Term:tendon cell differentiation
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Accession:GO:0035990 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.
Synonyms:exact_synonym: muscle attachment cell differentiation
 related_synonym: tenocyte differentiation


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tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISS UniProtKB GO_REF:0000024 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G MKX mohawk homeobox ISO (MGI:5287220|PMID:20696843) MGI PMID:20696843 MGI:5287220 NCBI chr10:27,672,874...27,745,819
Ensembl chr10:27,672,874...27,746,060
JBrowse link
G SCX scleraxis bHLH transcription factor ISS UniProtKB GO_REF:0000024 NCBI chr 8:144,265,060...144,268,483
Ensembl chr 8:144,266,453...144,268,481
JBrowse link
G TNMD tenomodulin IEA Ensembl GO_REF:0000107 NCBI chr  X:100,584,936...100,599,885
Ensembl chr  X:100,584,936...100,599,885
JBrowse link
positive regulation of tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDF7 growth differentiation factor 7 IEA Ensembl GO_REF:0000107 NCBI chr 2:20,667,144...20,679,243
Ensembl chr 2:20,667,144...20,679,243
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18672
    cellular process 17690
      cellular developmental process 4995
        cell differentiation 4891
          tendon cell differentiation 5
            negative regulation of tendon cell differentiation 0
            positive regulation of tendon cell differentiation 1
            regulation of tendon cell differentiation + 1
Path 2
Term Annotations click to browse term
  biological_process 18672
    developmental process 7466
      anatomical structure development 6873
        tissue development 2422
          connective tissue development 313
            tendon development 8
              tendon formation 5
                tendon cell differentiation 5
                  negative regulation of tendon cell differentiation 0
                  positive regulation of tendon cell differentiation 1
                  regulation of tendon cell differentiation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.