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ONTOLOGY REPORT - ANNOTATIONS


Term:tendon cell differentiation
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Accession:GO:0035990 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.
Synonyms:exact_synonym: muscle attachment cell differentiation
 related_synonym: tenocyte differentiation


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tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
G MKX mohawk homeobox ISO (MGI:5287220|PMID:20696843) MGI PMID:20696843 MGI:5287220 NCBI chr10:39,096,778...39,173,384
Ensembl chr10:39,096,782...39,172,199
JBrowse link
G SCX scleraxis bHLH transcription factor ISO (MGI:3715390|PMID:17567668), (MGI:4418577|PMID:20059955) UniProt PMID:17567668, PMID:20059955 MGI:3715390, MGI:4418577 NCBI chr 4:500,884...503,276
Ensembl chr 4:501,172...502,994
JBrowse link
G TNMD tenomodulin ISO PMID:21412429 UniProt PMID:21412429 RGD:8553701 NCBI chr  X:82,269,323...82,292,083
Ensembl chr  X:82,269,239...82,292,248
JBrowse link
positive regulation of tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDF7 growth differentiation factor 7 IEA Ensembl GO_REF:0000107 NCBI chr 3:117,586,188...117,592,541
Ensembl chr 3:117,588,431...117,592,466
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16548
    cellular process 15780
      cellular developmental process 4143
        cell differentiation 4056
          tendon cell differentiation 5
            negative regulation of tendon cell differentiation 0
            positive regulation of tendon cell differentiation 1
            regulation of tendon cell differentiation + 1
Path 2
Term Annotations click to browse term
  biological_process 16548
    developmental process 6302
      anatomical structure development 5842
        tissue development 2015
          connective tissue development 294
            tendon development 8
              tendon formation 5
                tendon cell differentiation 5
                  negative regulation of tendon cell differentiation 0
                  positive regulation of tendon cell differentiation 1
                  regulation of tendon cell differentiation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.