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ONTOLOGY REPORT - ANNOTATIONS


Term:tendon cell differentiation
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Accession:GO:0035990 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.
Synonyms:exact_synonym: muscle attachment cell differentiation
 related_synonym: tenocyte differentiation


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tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO (MGI:4418577|PMID:20059955) UniProt PMID:20059955 MGI:4418577 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Mkx mohawk homeobox ISO (MGI:5287220|PMID:20696843) MGI PMID:20696843 MGI:5287220 NCBI chrNW_004936613:2,019,815...2,083,724 JBrowse link
G Scx scleraxis bHLH transcription factor ISO (MGI:3715390|PMID:17567668), (MGI:4418577|PMID:20059955) UniProt PMID:17567668, PMID:20059955 MGI:3715390, MGI:4418577 NCBI chrNW_004936470:7,966,096...7,972,379 JBrowse link
G Tnmd tenomodulin ISO PMID:21412429 UniProt PMID:21412429 RGD:8553701 NCBI chrNW_004936584:5,803,309...5,818,643 JBrowse link
positive regulation of tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdf7 growth differentiation factor 7 ISO (MGI:5294519|PMID:21412429) UniProt PMID:21412429 MGI:5294519 NCBI chrNW_004936493:10,808,714...10,812,761 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12002
    cellular process 11179
      cellular developmental process 3662
        cell differentiation 3600
          tendon cell differentiation 5
            negative regulation of tendon cell differentiation 0
            positive regulation of tendon cell differentiation 1
            regulation of tendon cell differentiation + 1
Path 2
Term Annotations click to browse term
  biological_process 12002
    developmental process 5648
      anatomical structure development 5286
        tissue development 1870
          connective tissue development 275
            tendon development 8
              tendon formation 5
                tendon cell differentiation 5
                  negative regulation of tendon cell differentiation 0
                  positive regulation of tendon cell differentiation 1
                  regulation of tendon cell differentiation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.