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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate interconversion
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Accession:GO:0035999 term browser browse the term
Definition:The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
Synonyms:xref: MetaCyc:PWY-2201;   UniPathway:UPA00193


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tetrahydrofolate interconversion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmgdh dimethylglycine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 2:23,289,376...23,370,360
Ensembl chr 2:23,289,374...23,370,477
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G LOC680432 similar to methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:121,490,787...121,493,932
Ensembl chr 3:121,490,812...121,493,714
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:1881876)
(MGI:MGI:5503248|PMID:23704330)
UniProt
RGD
PMID:1881876, PMID:23704330, PMID:21873635 GO_REF:0000041, MGI:MGI:5503248, RGD:13792537 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21163947, PMID:21873635 GO_REF:0000041, RGD:7244288, RGD:13792537 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
G Mthfr methylenetetrahydrofolate reductase IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
UniProtKB:P53128 (PMID:10551815), (PMID:12673793), (PMID:25736335)
UniProt
RGD
PMID:10551815, PMID:12673793, PMID:25736335, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase ISO
IBA
(PMID:12764149)
PMID:21873635
RGD PMID:12764149, PMID:21873635 RGD:13792537 NCBI chr 8:96,564,877...96,614,386
Ensembl chr 8:96,564,877...96,614,348
JBrowse link
G Sardh sarcosine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 3:5,737,203...5,802,153
Ensembl chr 3:5,737,200...5,802,129
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO
IEA
IBA
(PMID:24698160)
GO_REF:0000041
PMID:21873635
RGD
UniProt
PMID:24698160, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Tyms thymidylate synthetase ISO (PMID:15093541) RGD PMID:15093541 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    cellular process 18788
      cellular metabolic process 11067
        one-carbon metabolic process 43
          tetrahydrofolate interconversion 13
Path 2
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      organic substance metabolic process 11639
        organic acid metabolic process 1090
          oxoacid metabolic process 1061
            carboxylic acid metabolic process 1005
              folic acid-containing compound metabolic process 28
                tetrahydrofolate metabolic process 21
                  tetrahydrofolate interconversion 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.