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ONTOLOGY REPORT - ANNOTATIONS


Term:mediator complex assembly
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Accession:GO:0036034 term browser browse the term
Definition:The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


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positive regulation of mediator complex assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Med25 mediator complex subunit 25 ISO (PMID:17641689) RGD PMID:17641689 NCBI chr 1:100,872,240...100,887,864
Ensembl chr 1:100,874,976...100,887,853
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  biological_process 20014
    cellular process 18788
      cellular component organization or biogenesis 6766
        cellular component organization 6510
          cellular component assembly 2967
            protein-containing complex assembly 1603
              cellular protein-containing complex assembly 1130
                mediator complex assembly 1
                  negative regulation of mediator complex assembly 0
                  positive regulation of mediator complex assembly 1
                  regulation of mediator complex assembly + 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.