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ONTOLOGY REPORT - ANNOTATIONS


Term:MKS complex
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Accession:GO:0036038 term browser browse the term
Definition:A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
Comment:Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
Synonyms:exact_synonym: MKS module
 narrow_synonym: B9 complex;   tectonic complex;   tectonic-like complex
 broad_synonym: TCTN-B9D complex


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MKS complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahi1 Abelson helper integration site 1 JBrowse link 1 16,478,127 16,601,769 RGD:1624291
RGD:1600115
G B9d1 B9 domain containing 1 JBrowse link 10 47,784,294 47,794,399 RGD:1600115
RGD:13792537
RGD:1624291
G B9d2 B9 domain containing 2 JBrowse link 1 82,473,254 82,479,704 RGD:1624291
RGD:13792537
RGD:1600115
G Cc2d2a coiled-coil and C2 domain containing 2A JBrowse link 14 71,895,128 71,979,452 RGD:1624291
G Cep290 centrosomal protein 290 JBrowse link 7 40,217,269 40,306,327 RGD:1624291
G Kctd10 potassium channel tetramerization domain containing 10 JBrowse link 12 47,992,079 48,010,531 RGD:1624291
G LOC108348055 B9 domain-containing protein 1 JBrowse link 10 49,019,745 49,029,851 RGD:1600115
RGD:13792537
G Mks1 MKS transition zone complex subunit 1 JBrowse link 10 75,149,814 75,160,481 RGD:1600115
RGD:13792537
RGD:1624291
G Tctn1 tectonic family member 1 JBrowse link 12 39,790,948 39,828,215 RGD:1624291
RGD:13792537
G Tctn2 tectonic family member 2 JBrowse link 12 37,400,896 37,427,256 RGD:1600115
RGD:13792537
RGD:1624291
G Tmem107 transmembrane protein 107 JBrowse link 10 55,653,694 55,656,270 RGD:1624291
RGD:13792537
RGD:1600115
G Tmem17 transmembrane protein 17 JBrowse link 14 107,268,235 107,308,546 RGD:1624291
RGD:1600115
G Tmem216 transmembrane protein 216 JBrowse link 1 226,601,201 226,606,417 RGD:1624291
RGD:1600115
G Tmem231 transmembrane protein 231 JBrowse link 19 44,137,444 44,158,624 RGD:1624291
RGD:1600115
G Tmem67 transmembrane protein 67 JBrowse link 5 25,666,138 25,721,056 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20118
    protein-containing complex 5962
      MKS complex 15
Path 2
Term Annotations click to browse term
  cellular_component 20118
    cellular anatomical entity 19774
      cell projection 2527
        plasma membrane bounded cell projection 2460
          cilium 681
            ciliary transition zone 76
              MKS complex 15
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.