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Term:phenotypic switching
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Accession:GO:0036166 term browser browse the term
Definition:A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
Comment:Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
Synonyms:related_synonym: phenotypic dimorphism


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phenotypic switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:1624291
RGD:1600115
negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:1600115
RGD:1624291
G Fgf9 fibroblast growth factor 9 JBrowse link 15 38,341,657 38,386,945 RGD:13601993
positive regulation of vascular smooth muscle cell dedifferentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1624291
RGD:1600115
positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1624291
regulation of phenotypic switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myocd myocardin JBrowse link 10 51,682,053 51,781,458 RGD:1624291
RGD:1600115
regulation of vascular smooth muscle cell dedifferentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Olfm2 olfactomedin 2 JBrowse link 8 21,684,307 21,762,000 RGD:13441204

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