Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:phenotypic switching
go back to main search page
Accession:GO:0036166 term browser browse the term
Definition:A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
Comment:Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
Synonyms:related_synonym: phenotypic dimorphism


show annotations for term's descendants           Sort by:
 
phenotypic switching term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO MGI:MGI:4418499 (MGI:MGI:5577209|PMID:24584053) RGD PMID:24584053 MGI:MGI:5577209 NCBI chr20:4,576,033...4,592,980
Ensembl chr20:4,576,057...4,592,980
JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 IEA
ISO
GO_REF:0000107
(PMID:27021683)
Ensembl
RGD
PMID:27021683 GO_REF:0000107 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Fgf9 fibroblast growth factor 9 IMP PMID:28259995 BHF-UCL PMID:28259995 RGD:13601993 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfb platelet derived growth factor subunit B ISO
IEA
(PMID:19088079)
GO_REF:0000107
RGD
Ensembl
PMID:19088079 GO_REF:0000107 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sod2 superoxide dismutase 2 ISO (PMID:27021683) RGD PMID:27021683 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
regulation of phenotypic switching term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myocd myocardin ISO
IEA
RNAcentral:URS0000527F89_10090 (MGI:MGI:4354665|PMID:19578358)
GO_REF:0000107
RGD
Ensembl
PMID:19578358 GO_REF:0000107, MGI:MGI:4354665 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 IMP PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chr 8:21,684,307...21,762,000
Ensembl chr 8:21,681,266...21,743,338
JBrowse link

Term paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.