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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular response to decreased oxygen levels
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Accession:GO:0036294 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
Comment:This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'cellular response to hypoxia ; GO:0071456'.
Synonyms:exact_synonym: cellular response to lowered oxygen levels


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cellular response to decreased oxygen levels term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO (MGI:MGI:5584033|PMID:24875179) MGI PMID:24875179 MGI:MGI:5584033 NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Cpeb4 cytoplasmic polyadenylation element binding protein 4 ISO PMID:20937770 UniProt PMID:20937770 RGD:8553637 NCBI chrNW_004936609:1,793,027...1,858,586 JBrowse link
G Pick1 protein interacting with PRKCA 1 ISO PMID:23843614 UniProt PMID:23843614 RGD:8553949 NCBI chrNW_004936492:3,098,196...3,115,921 JBrowse link
G Pten phosphatase and tensin homolog ISO (MGI:MGI:5584033|PMID:24875179) MGI PMID:24875179 MGI:MGI:5584033 NCBI chrNW_004936735:1,252,414...1,338,318 JBrowse link
cellular response to anoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator ISO RGD PMID:14975182 RGD:1599599 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
G Daxx death domain associated protein ISO RGD PMID:17289031 RGD:9587773 NCBI chrNW_004936476:25,546,091...25,550,390 JBrowse link
G Eef2k eukaryotic elongation factor 2 kinase ISO RGD PMID:12194824 RGD:8553742 NCBI chrNW_004936501:7,160,134...7,205,231 JBrowse link
cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO (PMID:18371312) BHF-UCL PMID:18371312 NCBI chrNW_004936497:13,242,644...13,269,007 JBrowse link
G Adam8 ADAM metallopeptidase domain 8 ISO (PMID:18566576) BHF-UCL PMID:18566576 NCBI chrNW_004936486:19,389,925...19,403,577 JBrowse link
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:19098126 RGD:8548506 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Ak4 adenylate kinase 4 ISO (PMID:19130895), (PMID:23474458), (PMID:26980435), (PMID:30696468) UniProt PMID:19130895, PMID:23474458, PMID:26980435, PMID:30696468 NCBI chrNW_004936692:2,593,409...2,654,583 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:20515660 RGD:5509097 NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Angpt4 angiopoietin 4 ISO (PMID:12958144) UniProtKB PMID:12958144 NCBI chrNW_004936485:17,675,948...17,710,512 JBrowse link
G Ankrd1 ankyrin repeat domain 1 ISO RGD PMID:19299913 RGD:5133278 NCBI chrNW_004936601:3,502,844...3,510,919 JBrowse link
G Aqp1 aquaporin 1 (Colton blood group) ISO (PMID:18275976) UniProtKB PMID:18275976 NCBI chrNW_004936478:7,146,997...7,160,369 JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) ISO (PMID:24462679) MGI PMID:24462679 NCBI chrNW_004936524:1,963,427...1,969,977 JBrowse link
G Asl argininosuccinate lyase ISO RGD PMID:11097477 RGD:1599264 NCBI chrNW_004936543:7,688,788...7,699,842 JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b ISO RGD PMID:29300489 RGD:13792656 NCBI chrNW_004936690:120,572...135,509 JBrowse link
G Atp7a ATPase copper transporting alpha ISO RGD PMID:21346155 RGD:11341705 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G B3gat1 beta-1,3-glucuronyltransferase 1 ISO RGD PMID:21400481 RGD:14390075 NCBI chrNW_004936684:1,252,874...1,275,469 JBrowse link
G Bad BCL2 associated agonist of cell death ISO (PMID:20810912) UniProtKB PMID:20810912 NCBI chrNW_004936599:4,924,349...4,933,683 JBrowse link
G Bbc3 BCL2 binding component 3 ISO (PMID:20810912) UniProtKB PMID:20810912 NCBI chrNW_004936664:962,115...966,797 JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO (MGI:MGI:77298|PMID:7595537)
with serum deprivation
MGI
RGD
PMID:7595537, PMID:20669351 MGI:MGI:77298, RGD:11353793 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Bcl2l1 BCL2 like 1 ISO with serum deprivation RGD PMID:20669351 RGD:11353793 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:19565561 RGD:4891057 NCBI chrNW_004936604:548,844...551,031 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO (PMID:19273585)
(PMID:20436456)
RGD
MGI
BHF-UCL
PMID:17379825, PMID:19273585, PMID:20436456 RGD:9685412 NCBI chrNW_004936486:18,449,371...18,460,435 JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO (PMID:19273585) MGI PMID:19273585 NCBI chrNW_004936757:499,485...523,494 JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 ISO RGD PMID:12511571 RGD:11251702 NCBI chrNW_004936490:3,001,445...3,139,538 JBrowse link
G Casr calcium sensing receptor ISO RGD PMID:21073657 RGD:7206834 NCBI chrNW_004936536:8,574,064...8,599,446 JBrowse link
G Cbs cystathionine beta-synthase ISO PMID:20149843 UniProt PMID:20149843 RGD:8554341 NCBI chrNW_004936500:976,043...1,003,559 JBrowse link
G Ccna2 cyclin A2 ISO RGD PMID:25289051 RGD:10054493 NCBI chrNW_004936662:1,073,460...1,079,136 JBrowse link
G Ccnb1 cyclin B1 ISO RGD PMID:12374461 RGD:2316579 NCBI chrNW_004936480:400,287...407,677 JBrowse link
G Cflar CASP8 and FADD like apoptosis regulator ISO RGD PMID:12031707 RGD:8663470 NCBI chrNW_004936726:381,888...425,565 JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 ISO (PMID:18752464)
(MGI:MGI:5543770|PMID:18752464)
UniProtKB PMID:18752464 MGI:MGI:5543770 NCBI chrNW_004936483:17,216,288...17,296,430 JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 ISO (MGI:MGI:5543770|PMID:18752464)
(PMID:18752464)
UniProtKB PMID:18752464 MGI:MGI:5543770 NCBI chrNW_004936477:12,727,325...12,798,733 JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO RGD PMID:24282625 RGD:9589039 NCBI chrNW_004936493:6,963,406...7,013,256 JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:20969567 RGD:7248614 NCBI chrNW_004936609:790,647...795,187 JBrowse link
G E2f1 E2F transcription factor 1 ISO RGD PMID:19088195 RGD:2316261 NCBI chrNW_004936561:6,894,827...6,901,058 JBrowse link
G Edn1 endothelin 1 ISO RGD PMID:9551744 RGD:8662285 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:21220915 RGD:5131857 NCBI chrNW_004936531:7,625,956...7,629,041 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO RGD PMID:10100614 RGD:10401146 NCBI chrNW_004936710:1,446,030...1,461,945 JBrowse link
G Eln elastin ISO RGD PMID:16055482 RGD:9585727 NCBI chrNW_004936543:3,135,169...3,165,023 JBrowse link
G Endog endonuclease G ISO RGD PMID:17379825 RGD:9685412 NCBI chrNW_004936487:16,282,115...16,285,486 JBrowse link
G Eno1 enolase 1 ISO PMID:15459207 CAFA PMID:15459207 RGD:12793039 NCBI chrNW_004936623:3,115,357...3,130,289 JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO (PMID:11573933) RGD
UniProtKB
PMID:11573933, PMID:12099714 RGD:11041576 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha ISO RGD PMID:12752442 RGD:10401130 NCBI chrNW_004936697:2,154,517...2,199,913 JBrowse link
G Fabp1 fatty acid binding protein 1 ISO (PMID:16175609) UniProtKB PMID:16175609 NCBI chrNW_004936712:738,361...743,073 JBrowse link
G Fam162a family with sequence similarity 162 member A ISO (MGI:MGI:5319611|PMID:17316997)
(PMID:15082785)
UniProtKB PMID:15082785, PMID:17316997 MGI:MGI:5319611 NCBI chrNW_004936536:8,697,631...8,725,667 JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:12031707 RGD:8663470 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO RGD PMID:11981751 RGD:634296 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Fmn2 formin 2 ISO (PMID:23375502) UniProtKB PMID:23375502 NCBI chrNW_004936526:9,832,790...10,169,488 JBrowse link
G Fndc1 fibronectin type III domain containing 1 ISO PMID:19723622 MGI PMID:19723622 RGD:8554041 NCBI chrNW_004936489:10,760,209...10,820,377 JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:24278276 RGD:10402204 NCBI chrNW_004936564:4,788,036...4,907,600 JBrowse link
G Gata6 GATA binding protein 6 ISO (PMID:21127043) UniProtKB PMID:21127043 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Gnb1 G protein subunit beta 1 ISO PMID:19723622 MGI PMID:19723622 RGD:8554041 NCBI chrNW_004936737:1,518,855...1,554,926 JBrowse link
G Gngt1 G protein subunit gamma transducin 1 ISO PMID:19723622 MGI PMID:19723622 RGD:8554041 NCBI chrNW_004936803:67,933...71,508 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO (PMID:19782034), (PMID:20810912)
(MGI:MGI:5528778|PMID:24011070)
(PMID:11573933), (PMID:19528298), (PMID:20889502)
UniProt
MGI
RGD
UniProtKB
PMID:11573933, PMID:18248612, PMID:19220706, PMID:19528298, PMID:19782034, PMID:20810912, PMID:20889502, PMID:24011070 MGI:MGI:5528778, RGD:9068456, RGD:9068884 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha NOT ISO (PMID:11573933) UniProtKB PMID:11573933 NCBI chrNW_004936664:296,288...323,143 JBrowse link
G Higd1a HIG1 hypoxia inducible domain family member 1A ISO (MGI:MGI:3654896|PMID:16815968), (MGI:MGI:5306879|PMID:21856340)
(MGI:MGI:5643884|PMID:25683712)
MGI PMID:16815968, PMID:21856340, PMID:25683712 MGI:MGI:3654896, MGI:MGI:5306879, MGI:MGI:5643884 NCBI chrNW_004936695:2,330,939...2,341,387 JBrowse link
G Hilpda hypoxia inducible lipid droplet associated ISO (PMID:10690527) UniProtKB PMID:10690527 NCBI chrNW_004936479:15,582,260...15,583,213 JBrowse link
G Hmox1 heme oxygenase 1 ISO (PMID:12511571) UniProtKB PMID:12511571 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:24177414 RGD:10445837 NCBI chrNW_004936530:2,401,053...2,425,989 JBrowse link
G Hp1bp3 heterochromatin protein 1 binding protein 3 ISO (PMID:25100860) UniProtKB PMID:25100860 NCBI chrNW_004936474:6,665,989...6,699,722 JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO (PMID:9020069)
(PMID:10837345)
ParkinsonsUK-UCL PMID:9020069, PMID:10837345 NCBI chrNW_004936542:4,005,616...4,018,135 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:20631551 RGD:8662392 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Il7 interleukin 7 ISO RGD PMID:19055876 RGD:10402937 NCBI chrNW_004936702:110,625...162,957 JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO RGD PMID:15793310 RGD:1579809 NCBI chrNW_004936809:891,407...900,311 JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO RGD PMID:22159112 RGD:6893269 NCBI chrNW_004936471:36,547,552...36,601,327 JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 ISO RGD PMID:17285299 RGD:6482794 NCBI chrNW_004936577:3,896,455...4,198,396 JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor type 2 ISO RGD PMID:17285299 RGD:6482794 NCBI chrNW_004936548:646,019...1,120,426 JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 ISO PMID:25352783 UniProt PMID:25352783 RGD:10047379 NCBI chrNW_004936605:4,370,222...4,828,972 JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:24705172 RGD:9831164 NCBI chrNW_004936628:3,155,261...3,284,375 JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO RGD PMID:12215606 RGD:2316539 NCBI chrNW_004936493:5,767,779...5,772,043 JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 ISO RGD PMID:19461047 RGD:10412041 NCBI chrNW_004936609:4,451,526...4,458,665 JBrowse link
G Lmna lamin A/C ISO (PMID:20810912) UniProtKB PMID:20810912 NCBI chrNW_004936580:5,374,208...5,395,442 JBrowse link
G LOC101956526 cytochrome c oxidase subunit 4 isoform 2, mitochondrial ISO RGD PMID:23303788 RGD:11344908 NCBI chrNW_004936485:18,631,826...18,637,675 JBrowse link
G LOC101966992 cytochrome b-245 heavy chain ISO RGD PMID:21302291 RGD:11040609 NCBI chrNW_004936502:4,631,750...4,676,686 JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:20810912) UniProtKB PMID:20810912 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Mdm4 MDM4 regulator of p53 ISO (PMID:20810912) UniProtKB PMID:20810912 NCBI chrNW_004936567:268,151...299,494 JBrowse link
G Mfn1 mitofusin 1 ISO RGD PMID:27833818 RGD:12910766 NCBI chrNW_004936566:3,737,315...3,775,894 JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:28478070 RGD:12910733 NCBI chrNW_004936474:767,754...795,258 JBrowse link
G Mgarp mitochondria localized glutamic acid rich protein ISO (MGI:MGI:3850758|PMID:19528298) UniProtKB PMID:19528298 MGI:MGI:3850758 NCBI chrNW_004936535:8,321,443...8,336,773 JBrowse link
G Mief1 mitochondrial elongation factor 1 ISO RGD PMID:25911325 RGD:12880381 NCBI chrNW_004936492:2,118,565...2,132,181 JBrowse link
G Mif macrophage migration inhibitory factor ISO RGD PMID:19462902 RGD:4890975 NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor ISO RGD PMID:15642952 RGD:10449018 NCBI chrNW_004936474:24,744,673...24,757,189 JBrowse link
G Mst1 macrophage stimulating 1 ISO RGD PMID:23647599 RGD:10448278 NCBI chrNW_004936529:1,298,853...1,306,088 JBrowse link
G Mt3 metallothionein 3 ISO (PMID:18206644) UniProtKB PMID:18206644 NCBI chrNW_004936475:8,864,512...8,866,516 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (MGI:MGI:3654795|PMID:16915281) UniProtKB PMID:16915281 MGI:MGI:3654795 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO (PMID:15459207) CAFA PMID:15459207 NCBI chrNW_004936470:20,480,844...20,485,955 JBrowse link
G Myocd myocardin ISO RGD PMID:20621093 RGD:5132874 NCBI chrNW_004936595:5,256,615...5,356,563 JBrowse link
G Ndnf neuron derived neurotrophic factor ISO (PMID:24706764) UniProtKB PMID:24706764 NCBI chrNW_004936662:593,848...624,974 JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO (PMID:20810912) UniProtKB PMID:20810912 NCBI chrNW_004936470:16,051,291...16,102,563 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2 like 2 ISO RGD PMID:23904790 RGD:10412703 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
G Nkx3-1 NK3 homeobox 1 ISO (PMID:21056661) UniProtKB PMID:21056661 NCBI chrNW_004936555:7,087,677...7,091,334 JBrowse link
G Nog noggin ISO RGD PMID:25740156 RGD:12801489 NCBI chrNW_004936490:6,262,651...6,264,069 JBrowse link
G Nol3 nucleolar protein 3 ISO PMID:22082675 UniProt PMID:22082675 RGD:10047303 NCBI chrNW_004936475:17,644,299...17,648,213 JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (PMID:22522597) UniProtKB PMID:22522597 NCBI chrNW_004936664:1,334,487...1,343,867 JBrowse link
G Npepps aminopeptidase puromycin sensitive ISO (PMID:21056661) UniProtKB PMID:21056661 NCBI chrNW_004936490:13,659,729...13,737,510 JBrowse link
G Npm1 nucleophosmin 1 ISO RGD PMID:21444791 RGD:11535018 NCBI chrNW_004936609:3,712,628...3,725,635 JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase ISO RGD PMID:27833818 RGD:12910766 NCBI chrNW_004936711:1,027,531...1,113,796 JBrowse link
G Oprd1 opioid receptor delta 1 ISO (PMID:24613828) ParkinsonsUK-UCL PMID:24613828 NCBI chrNW_004936474:12,860,293...12,902,389 JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta ISO (PMID:12095988) BHF-UCL PMID:12095988 NCBI chrNW_004936594:5,368,199...5,379,215 JBrowse link
G Palld palladin, cytoskeletal associated protein ISO RGD PMID:16481593 RGD:2325785 NCBI chrNW_004936516:786,358...1,151,910 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 ISO RGD PMID:24177414 RGD:10445837 NCBI chrNW_004936530:361,872...367,005 JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO RGD PMID:23647599 RGD:10448278 NCBI chrNW_004936489:2,677,740...2,720,387 JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO (PMID:11130727) CAFA PMID:11130727 NCBI chrNW_004936547:286,267...310,062 JBrowse link
G Phb2 prohibitin 2 ISO RGD PMID:25031298 RGD:12903263 NCBI chrNW_004936709:854,493...859,182 JBrowse link
G Pink1 PTEN induced kinase 1 ISO (PMID:24553947)
(MGI:MGI:5558956|PMID:24553947)
ParkinsonsUK-UCL PMID:24553947 MGI:MGI:5558956 NCBI chrNW_004936474:6,574,471...6,589,478 JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:19490965 RGD:7241802 NCBI chrNW_004936521:5,238,128...5,243,829 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO (PMID:14699081), (PMID:20810912) UniProtKB PMID:14699081, PMID:20810912 NCBI chrNW_004936497:4,985,995...4,986,720 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:22527940 RGD:7242177 NCBI chrNW_004936477:4,881,230...5,488,208 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:17720864 RGD:2316813 NCBI chrNW_004936518:1,817,051...1,843,376 JBrowse link
G Prkce protein kinase C epsilon ISO (MGI:MGI:3776183|PMID:18070622) MGI PMID:18070622 MGI:MGI:3776183 NCBI chrNW_004936508:6,018,374...6,495,216 JBrowse link
G Pten phosphatase and tensin homolog ISO (MGI:MGI:5584033|PMID:24875179) MGI PMID:24875179 MGI:MGI:5584033 NCBI chrNW_004936735:1,252,414...1,338,318 JBrowse link
G Ptgis prostaglandin I2 synthase ISO (PMID:21296955) UniProtKB PMID:21296955 NCBI chrNW_004936514:4,775,884...4,814,574 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO (PMID:21296955) UniProtKB PMID:21296955 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ptn pleiotrophin ISO RGD PMID:16226713, PMID:17925408 RGD:10044023, RGD:9834996 NCBI chrNW_004936592:1,706,979...1,806,345 JBrowse link
G Rgcc regulator of cell cycle ISO (PMID:19652095) BHF-UCL PMID:19652095 NCBI chrNW_004936667:232,807...245,131 JBrowse link
G Rnf146 ring finger protein 146 ISO RGD PMID:26218637 RGD:13524866 NCBI chrNW_004936639:2,394,566...2,417,452 JBrowse link
G Rora RAR related orphan receptor A ISO (PMID:18658046) UniProtKB PMID:18658046 NCBI chrNW_004936471:21,402,056...21,567,908 JBrowse link
G Rtn4 reticulon 4 ISO (MGI:MGI:6274961|PMID:27763637) UniProt PMID:27763637 MGI:MGI:6274961 NCBI chrNW_004936491:1,407,414...1,474,031 JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 ISO PMID:28029095 UniProt PMID:28029095 RGD:14390052 NCBI chrNW_004936469:13,872,701...14,019,170 JBrowse link
G Sdhd succinate dehydrogenase complex subunit D ISO (MGI:MGI:3525749|PMID:15572694) MGI PMID:15572694 MGI:MGI:3525749 NCBI chrNW_004936612:2,357,336...2,369,204 JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:10590062 RGD:8547811 NCBI chrNW_004936543:1,032,543...1,040,956 JBrowse link
G Sfrp1 secreted frizzled related protein 1 ISO (PMID:11932307) UniProtKB PMID:11932307 NCBI chrNW_004936785:1,276,478...1,320,397 JBrowse link
G Sirt1 sirtuin 1 ISO (PMID:20620956) UniProtKB PMID:20620956 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Sirt2 sirtuin 2 ISO (PMID:24681946) UniProtKB PMID:24681946 NCBI chrNW_004936661:1,828,868...1,849,892 JBrowse link
G Sirt4 sirtuin 4 ISO RGD PMID:24029877 RGD:9586053 NCBI chrNW_004936668:628,875...633,425 JBrowse link
G Slc11a2 solute carrier family 11 member 2 ISO RGD PMID:21325818 RGD:5688411 NCBI chrNW_004936512:8,590,302...8,622,121 JBrowse link
G Slc29a1 solute carrier family 29 member 1 (Augustine blood group) ISO RGD PMID:10646513 RGD:1598899 NCBI chrNW_004936476:15,849,054...15,862,486 JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO RGD PMID:20868366 RGD:7349316 NCBI chrNW_004936595:567,267...574,051 JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO RGD PMID:17394575 RGD:1642726 NCBI chrNW_004936508:10,894,918...11,256,084 JBrowse link
G Slc8a3 solute carrier family 8 member A3 ISO (MGI:MGI:5693358|PMID:24101730) UniProtKB PMID:24101730 MGI:MGI:5693358 NCBI chrNW_004936495:13,236,480...13,370,973 JBrowse link
G Slc9a1 solute carrier family 9 member A1 ISO RGD PMID:20868366 RGD:7349316 NCBI chrNW_004936474:11,460,266...11,517,420 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:20380727 RGD:2324980 NCBI chrNW_004936561:3,826,802...3,844,406 JBrowse link
G Stc1 stanniocalcin 1 ISO RGD PMID:15485913 RGD:2324700 NCBI chrNW_004936555:7,240,649...7,251,668 JBrowse link
G Stc2 stanniocalcin 2 ISO RGD PMID:15485913 RGD:2324700 NCBI chrNW_004936609:2,319,546...2,331,049 JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 ISO PMID:19953350 ARUK-UCL PMID:19953350 RGD:13507303 NCBI chrNW_004936501:328,767...330,963 JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 ISO (PMID:21402781) MGI PMID:21402781 NCBI chrNW_004936721:646,778...661,144 JBrowse link
G Suv39h2 suppressor of variegation 3-9 homolog 2 ISO (PMID:21402781) MGI PMID:21402781 NCBI chrNW_004936613:1,443,663...1,467,776 JBrowse link
G Tbl2 transducin beta like 2 ISO (PMID:25393282) ParkinsonsUK-UCL PMID:25393282 NCBI chrNW_004936543:2,825,990...2,833,908 JBrowse link
G Tert telomerase reverse transcriptase ISO (PMID:11313459) BHF-UCL
RGD
PMID:11313459, PMID:24376652 RGD:11038675 NCBI chrNW_004936815:468,987...492,666 JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase ISO (PMID:23185017) UniProtKB PMID:23185017 NCBI chrNW_004936606:4,518,525...4,540,109 JBrowse link
G Tp53 tumor protein p53 ISO (PMID:20810912) UniProtKB PMID:20810912 NCBI chrNW_004936595:919,807...935,367 JBrowse link
G Trpc1 transient receptor potential cation channel subfamily C member 1 ISO RGD PMID:19889962 RGD:7247600 NCBI chrNW_004936540:4,340,672...4,417,655 JBrowse link
G Trpc6 transient receptor potential cation channel subfamily C member 6 ISO RGD PMID:19889962 RGD:7247600 NCBI chrNW_004936551:6,173,588...6,282,971 JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:18297062)
(MGI:MGI:5284765|PMID:18297062)
BHF-UCL PMID:18297062 MGI:MGI:5284765 NCBI chrNW_004936546:5,331,220...5,332,669 JBrowse link
G Ubqln1 ubiquilin 1 ISO (PMID:12095988) BHF-UCL PMID:12095988 NCBI chrNW_004936828:543,651...588,673 JBrowse link
G Ucn2 urocortin 2 ISO RGD PMID:14519439 RGD:2306174 NCBI chrNW_004936529:347,411...348,040 JBrowse link
G Vasn vasorin ISO (MGI:MGI:5014460|PMID:21658601) MGI PMID:21658601 MGI:MGI:5014460 NCBI chrNW_004936694:128,398...138,954 JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:10575000) MGI PMID:10575000 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
G Vldlr very low density lipoprotein receptor ISO RGD PMID:19233325 RGD:2324641 NCBI chrNW_004936503:2,407,040...2,440,366 JBrowse link
G Zfp36l1 ZFP36 ring finger protein like 1 ISO (PMID:21832157) UniProtKB PMID:21832157 NCBI chrNW_004936495:12,045,679...12,050,737 JBrowse link
cellular response to oxygen-glucose deprivation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor mitochondria associated 1 ISO RGD PMID:14526224 RGD:10047409 NCBI chrNW_004936479:1,441,508...1,477,133 JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) ISO (MGI:MGI:5551666|PMID:24462679) MGI PMID:24462679 MGI:MGI:5551666 NCBI chrNW_004936524:1,963,427...1,969,977 JBrowse link
G Atf4 activating transcription factor 4 ISO RGD PMID:20444431 RGD:13464322 NCBI chrNW_004936492:2,114,478...2,115,969 JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:23421680 RGD:13514095 NCBI chrNW_004936512:6,652,836...6,666,171 JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:24229686 RGD:11038824 NCBI chrNW_004936542:4,136,389...4,235,746 JBrowse link
G Dnm1l dynamin 1 like ISO RGD PMID:23658809 RGD:12738215 NCBI chrNW_004936607:3,576,357...3,632,423 JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO RGD PMID:16135072 RGD:12904046 NCBI chrNW_004936471:36,547,552...36,601,327 JBrowse link
G Mfn1 mitofusin 1 ISO RGD PMID:23658809 RGD:12738215 NCBI chrNW_004936566:3,737,315...3,775,894 JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:23658809 RGD:12738215 NCBI chrNW_004936474:767,754...795,258 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO RGD PMID:28528966 RGD:13781879 NCBI chrNW_004936479:17,682,070...17,716,713 JBrowse link
G Ppp1r15a protein phosphatase 1 regulatory subunit 15A ISO RGD PMID:21525936 RGD:10054236 NCBI chrNW_004936664:2,910,609...2,914,205 JBrowse link
G Tsc1 TSC complex subunit 1 ISO PMID:23435171 ParkinsonsUK-UCL PMID:23435171 RGD:10448950 NCBI chrNW_004936487:19,331,183...19,386,841 JBrowse link
hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha ISO (MGI:MGI:60478|PMID:8470821) MGI PMID:8470821 MGI:MGI:60478 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G LOC101966992 cytochrome b-245 heavy chain ISO RGD PMID:21302291 RGD:11040609 NCBI chrNW_004936502:4,631,750...4,676,686 JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 ISO (PMID:21763680) UniProtKB PMID:21763680 NCBI chrNW_004936509:2,597,593...2,633,780 JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO (PMID:18718909) UniProtKB PMID:18718909 NCBI chrNW_004936624:141,745...213,495 JBrowse link
intrinsic apoptotic signaling pathway in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 ISO (PMID:20436456) BHF-UCL PMID:20436456 NCBI chrNW_004936486:18,449,371...18,460,435 JBrowse link
G Tp53 tumor protein p53 ISO (MGI:MGI:4867601|PMID:20935145) MGI PMID:20935145 MGI:MGI:4867601 NCBI chrNW_004936595:919,807...935,367 JBrowse link
negative regulation of cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule ISO (PMID:17505307) UniProtKB PMID:17505307 NCBI chrNW_004936557:5,030,788...5,051,864 JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 ISO (PMID:24895913) BHF-UCL PMID:24895913 NCBI chrNW_004936608:262,653...397,753 JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO RGD PMID:18539296 RGD:9590185 NCBI chrNW_004936762:99,335...137,833 JBrowse link
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eno1 enolase 1 ISO (PMID:15459207) CAFA PMID:15459207 NCBI chrNW_004936623:3,115,357...3,130,289 JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO PMID:11231630
(PMID:10037731)
ParkinsonsUK-UCL PMID:10037731, PMID:11231630 RGD:10047348 NCBI chrNW_004936542:4,005,616...4,018,135 JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO PMID:15459207 CAFA PMID:15459207 RGD:12793039 NCBI chrNW_004936471:26,589,251...26,628,302 JBrowse link
G Nol3 nucleolar protein 3 ISO PMID:10590251 UniProt PMID:10590251 RGD:10047155 NCBI chrNW_004936475:17,644,299...17,648,213 JBrowse link
G Pink1 PTEN induced kinase 1 ISO (MGI:MGI:5558956|PMID:24553947) ParkinsonsUK-UCL PMID:24553947 MGI:MGI:5558956 NCBI chrNW_004936474:6,574,471...6,589,478 JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 ISO (PMID:21075086) ParkinsonsUK-UCL PMID:21075086 NCBI chrNW_004936512:7,427,926...7,448,700 JBrowse link
negative regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Commd1 copper metabolism domain containing 1 ISO (MGI:MGI:3713589|PMID:17371845) MGI PMID:17371845 MGI:MGI:3713589 NCBI chrNW_004936491:7,247,160...7,421,039 JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 ISO (PMID:22735262) BHF-UCL PMID:22735262 NCBI chrNW_004936560:6,353,901...6,356,749 JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor ISO (PMID:11641274) UniProtKB PMID:11641274 NCBI chrNW_004936600:5,106,166...5,116,865 JBrowse link
G Sirt2 sirtuin 2 ISO (PMID:24681946) UniProtKB PMID:24681946 NCBI chrNW_004936661:1,828,868...1,849,892 JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO (PMID:11641274) UniProtKB PMID:11641274 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
positive regulation of cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnk2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:24705172 RGD:9831164 NCBI chrNW_004936628:3,155,261...3,284,375 JBrowse link
positive regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rwdd3 RWD domain containing 3 ISO (PMID:23469069)
(MGI:MGI:5569907|PMID:22009797)
UniProtKB
MGI
PMID:22009797, PMID:23469069 MGI:MGI:5569907 NCBI chrNW_004936537:4,019,337...4,031,951 JBrowse link
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo like kinase 3 ISO (PMID:20889502) UniProtKB PMID:20889502 NCBI chrNW_004936474:26,026,878...26,032,098 JBrowse link
G Sirt2 sirtuin 2 ISO (PMID:24681946) UniProtKB PMID:24681946 NCBI chrNW_004936661:1,828,868...1,849,892 JBrowse link
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha ISO (PMID:22735262)
(PMID:19652095), (PMID:24681946)
BHF-UCL PMID:19652095, PMID:22735262, PMID:24681946 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2 like 2 ISO (PMID:24844779) BHF-UCL PMID:24844779 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
G Notch1 notch receptor 1 ISO (MGI:MGI:5319604|PMID:18299578) UniProtKB PMID:18299578 MGI:MGI:5319604 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO (PMID:23303788) UniProtKB PMID:23303788 NCBI chrNW_004936477:3,354,336...3,445,248 JBrowse link
G Tp53 tumor protein p53 ISO (MGI:MGI:4867601|PMID:20935145) MGI PMID:20935145 MGI:MGI:4867601 NCBI chrNW_004936595:919,807...935,367 JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:19652095) BHF-UCL PMID:19652095 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
regulation of cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ajuba ajuba LIM protein ISO (PMID:22286099) UniProtKB PMID:22286099 NCBI chrNW_004936722:1,331,568...1,341,854 JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 ISO (PMID:23303788) UniProtKB PMID:23303788 NCBI chrNW_004936543:7,860,432...7,864,050 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO RGD PMID:18054269 RGD:9068899 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 ISO (MGI:MGI:6271078|PMID:29353861) ARUK-UCL PMID:29353861 MGI:MGI:6271078 NCBI chrNW_004936532:7,142,580...7,284,722 JBrowse link
G Usp19 ubiquitin specific peptidase 19 ISO (PMID:22128162) UniProtKB PMID:22128162 NCBI chrNW_004936529:814,649...826,008 JBrowse link
regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bach1 BTB domain and CNC homolog 1 ISO (PMID:12511571) UniProtKB PMID:12511571 NCBI chrNW_004936500:12,720,027...12,740,717 JBrowse link
G Egr1 early growth response 1 ISO (MGI:MGI:3847400|PMID:18323529) MGI PMID:18323529 MGI:MGI:3847400 NCBI chrNW_004936531:7,625,956...7,629,041 JBrowse link
G Stox1 storkhead box 1 ISO (PMID:24738702) UniProtKB PMID:24738702 NCBI chrNW_004936521:9,500,443...9,554,082 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    response to stimulus 6404
      response to abiotic stimulus 1325
        response to oxygen levels 454
          response to decreased oxygen levels 415
            cellular response to decreased oxygen levels 180
              cellular response to anoxia 3
              cellular response to hypoxia + 167
              cellular response to oxygen-glucose deprivation 12
              positive regulation of SREBP signaling pathway in response to decreased oxygen levels 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.