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Term:tyrosyl-RNA phosphodiesterase activity
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Accession:GO:0036317 term browser browse the term
Definition:Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.
Synonyms:exact_synonym: VPg unlinkase activity;   Y-pUpN PDE activity;   unlinkase activity;   uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity

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tyrosyl-RNA phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 IEA
PMID:22908287 GO_REF:0000107 NCBI chr17:42,229,667...42,241,025
Ensembl chr17:42,229,642...42,241,066
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Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      catalytic activity, acting on RNA 377
        tyrosyl-RNA phosphodiesterase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      hydrolase activity 2637
        hydrolase activity, acting on ester bonds 804
          phosphoric ester hydrolase activity 377
            phosphoric diester hydrolase activity 90
              tyrosyl-RNA phosphodiesterase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.