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ONTOLOGY REPORT - ANNOTATIONS


Term:Fas signaling pathway
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Accession:GO:0036337 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.
Synonyms:exact_synonym: Apo-1 signaling pathway;   CD95 signaling pathway;   Fas receptor signaling pathway;   FasR signaling pathway
 narrow_synonym: FAS ligand-Fas signaling pathway;   Fas-FasL signaling pathway
 related_synonym: FasL signaling pathway


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Fas signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8ap2 caspase 8 associated protein 2 ISO
IBA
(PMID:17245429)
PMID:21873635
RGD PMID:17245429, PMID:21873635 RGD:13792537 NCBI chr 5:47,853,699...47,891,147
Ensembl chr 5:47,853,818...47,891,668
JBrowse link
G Fas Fas cell surface death receptor ISO (PMID:11096076) RGD PMID:11096076 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
negative regulation of Fas signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmbim1 transmembrane BAX inhibitor motif containing 1 ISO
ISS
(PMID:21107705)
GO_REF:0000024
RGD
UniProt
PMID:21107705 GO_REF:0000024 NCBI chr 9:81,569,289...81,586,469
Ensembl chr 9:81,569,289...81,586,553
JBrowse link
regulation of Fas signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sp100 SP100 nuclear antigen ISO (PMID:17245429) RGD PMID:17245429 NCBI chr 9:92,675,103...92,718,489
Ensembl chr 9:92,681,078...92,717,929
JBrowse link
G Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 ISO
ISS
(PMID:25301068)
GO_REF:0000024
RGD
UniProt
PMID:25301068 GO_REF:0000024 NCBI chr19:52,733,161...52,750,307
Ensembl chr19:52,733,161...52,750,307
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      signal transduction 7015
        cell surface receptor signaling pathway 2782
          Fas signaling pathway 5
            negative regulation of Fas signaling pathway 1
            positive regulation of Fas signaling pathway 0
            regulation of Fas signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            cell surface receptor signaling pathway 2782
              Fas signaling pathway 5
                negative regulation of Fas signaling pathway 1
                positive regulation of Fas signaling pathway 0
                regulation of Fas signaling pathway + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.