ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta activation
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Accession:GO:0036363 term browser browse the term
Definition:The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.
Synonyms:exact_synonym: L-TGF-beta activation;   TGF-B activation;   TGF-beta activation;   TGFB activation;   TGFbeta activation;   latent TGF-beta activation


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transforming growth factor beta activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ltbp3 latent transforming growth factor beta binding protein 3 JBrowse link 1 221,099,155 221,116,096 RGD:1624291
RGD:1600115
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr2b activin A receptor type 2B JBrowse link 8 128,087,308 128,126,776 RGD:1624291
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291
RGD:1600115
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Furin furin (paired basic amino acid cleaving enzyme) JBrowse link 1 142,185,092 142,198,167 RGD:1600115
RGD:1624291
regulation of transforming growth factor beta activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1600115
RGD:1624291
G Itgb6 integrin subunit beta 6 JBrowse link 3 46,652,624 46,775,362 RGD:1600115
RGD:1624291
G Itgb8 integrin subunit beta 8 JBrowse link 6 147,089,280 147,172,846 RGD:1600115
RGD:1624291
G Lrrc32 leucine rich repeat containing 32 JBrowse link 1 163,443,972 163,457,426 RGD:1624291
G Ltbp1 latent transforming growth factor beta binding protein 1 JBrowse link 6 21,203,502 21,600,441 RGD:1600115
RGD:1624291
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrc32 leucine rich repeat containing 32 JBrowse link 1 163,443,972 163,457,426 RGD:1600115
RGD:1624291
transforming growth factor beta1 activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nrros negative regulator of reactive oxygen species JBrowse link 11 71,872,728 71,889,897 RGD:1600115
RGD:1624291

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.