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ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol biosynthetic process from calciol
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Accession:GO:0036378 term browser browse the term
Definition:Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms:exact_synonym: calcitriol biosynthesis from calciol;   vitamin D3 activation
 broad_synonym: 1alpha,25(OH)2D3 biosynthesis;   1alpha,25-dihydroxycholecalciferol biosynthesis;   1alpha,25-dihydroxyvitamin D3 biosynthesis


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calcitriol biosynthetic process from calciol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 9 81,968,285 81,998,213 RGD:1600115
RGD:1624291
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 JBrowse link 7 70,333,150 70,340,006 RGD:1624291
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 JBrowse link 1 184,060,521 184,106,604 RGD:1624291

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  biological_process 19439
    cellular process 18178
      cellular metabolic process 10639
        drug metabolic process 586
          calcitriol biosynthetic process from calciol 3
Path 2
Term Annotations click to browse term
  biological_process 19439
    metabolic process 11638
      primary metabolic process 10478
        lipid metabolic process 1315
          steroid metabolic process 306
            steroid biosynthetic process 159
              vitamin D biosynthetic process 11
                calcitriol biosynthetic process from calciol 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.