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Term:calcitriol biosynthetic process from calciol
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Accession:GO:0036378 term browser browse the term
Definition:Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms:exact_synonym: calcitriol biosynthesis from calciol;   vitamin D3 activation
 broad_synonym: 1alpha,25(OH)2D3 biosynthesis;   1alpha,25-dihydroxycholecalciferol biosynthesis;   1alpha,25-dihydroxyvitamin D3 biosynthesis

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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 IEA
PMID:15465040, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
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G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 ISO
(PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
RGD PMID:9415400, PMID:15795327, PMID:15972816, PMID:16549446, PMID:17023519, PMID:22862690, PMID:21873635 MGI:MGI:3590419, RGD:13792537 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 ISO (PMID:15465040), (PMID:18511070) RGD PMID:15465040, PMID:18511070 NCBI chr 1:184,060,521...184,106,604
Ensembl chr 1:184,093,920...184,106,200
JBrowse link
G LOC100909462 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537

Term paths to the root
Path 1
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  biological_process 20015
    cellular process 18788
      cellular metabolic process 11067
        cellular biosynthetic process 6053
          cellular alcohol biosynthetic process 4
            calcitriol biosynthetic process from calciol 4
Path 2
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      organic substance metabolic process 11639
        organic hydroxy compound metabolic process 538
          organic hydroxy compound biosynthetic process 241
            alcohol biosynthetic process 154
              polyol biosynthetic process 69
                calcitriol biosynthetic process from calciol 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.