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Term:TCR signalosome
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Accession:GO:0036398 term browser browse the term
Definition:A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.
Synonyms:exact_synonym: LAT signalosome;   linker for activation of T cells signalosome

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TCR signalosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lcp2 lymphocyte cytosolic protein 2 JBrowse link 10 18,996,523 19,043,289 RGD:1624291
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291

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  cellular_component 20119
    protein-containing complex 5963
      TCR signalosome 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.