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ONTOLOGY REPORT - ANNOTATIONS


Term:cell death in response to hydrogen peroxide
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Accession:GO:0036474 term browser browse the term
Definition:Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2).
Comment:This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0010421 'hydrogen peroxide-mediated programmed cell death'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
Synonyms:exact_synonym: cell death in response to H2O2
 related_synonym: hydrogen peroxide-mediated cell death


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cell death in response to hydrogen peroxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rnf112 ring finger protein 112 JBrowse link 10 47,719,034 47,726,050 RGD:1600115
RGD:1624291
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:1600115
RGD:1624291
intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
RGD:1600115
G Stk25 serine/threonine kinase 25 JBrowse link 9 100,767,578 100,779,715 RGD:1624291
RGD:1600115
negative regulation of hydrogen peroxide-induced cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epor erythropoietin receptor JBrowse link 8 22,969,737 22,974,468 RGD:10401070
G Gpr37 G protein-coupled receptor 37 JBrowse link 4 51,822,163 51,844,228 RGD:1624291
RGD:1600115
G Gpr37l1 G protein-coupled receptor 37-like 1 JBrowse link 13 51,985,698 51,992,547 RGD:1624291
RGD:1600115
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:10059424
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
RGD:1600115
G Ngb neuroglobin JBrowse link 6 111,126,259 111,131,699 RGD:9743949
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:10047164
RGD:10047212
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
G Pde8a phosphodiesterase 8A JBrowse link 1 143,036,083 143,160,395 RGD:1624291
RGD:1600115
G Psap prosaposin JBrowse link 20 29,831,302 29,856,876 RGD:1624291
RGD:1600115
G Pycr1 pyrroline-5-carboxylate reductase 1 JBrowse link 10 109,817,300 109,822,218 RGD:1624291
RGD:1600115
G Rnf146 ring finger protein 146 JBrowse link 1 30,856,923 30,873,814 RGD:13524867
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:1624291
RGD:1600115
negative regulation of hydrogen peroxide-induced neuron death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbxo7 F-box protein 7 JBrowse link 7 23,815,246 23,843,505 RGD:1624291
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1600115
RGD:1624291
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:1624291
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
G Reg3b regenerating family member 3 beta JBrowse link 4 109,467,272 109,470,510 RGD:9831400
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
RGD:1600115
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
RGD:1600115
negative regulation of hydrogen peroxide-mediated programmed cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glrx glutaredoxin JBrowse link 2 2,606,032 2,615,944 RGD:9686063
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:1624291
RGD:1600115
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:10047370
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1624291
RGD:1600115
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hsph1 heat shock protein family H (Hsp110) member 1 JBrowse link 12 6,322,685 6,341,898 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:8693356
RGD:1624291
G Trap1 TNF receptor-associated protein 1 JBrowse link 10 11,724,032 11,757,682 RGD:8693356
positive regulation of hydrogen peroxide-induced cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp1 forkhead box P1 JBrowse link 4 131,362,178 131,963,466 RGD:11561912
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
RGD:1600115
positive regulation of hydrogen peroxide-mediated programmed cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:8693407
G Endog endonuclease G JBrowse link 3 8,741,833 8,744,414 RGD:9685387
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:7327146
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:1624291
RGD:1600115
regulation of hydrogen peroxide-induced cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stk26 serine/threonine kinase 26 JBrowse link X 138,032,356 138,096,632 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:10047225

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    cellular process 17226
      cell death 2145
        cell death in response to oxidative stress 101
          cell death in response to hydrogen peroxide 39
            hydrogen peroxide-mediated programmed cell death + 15
            negative regulation of hydrogen peroxide-induced cell death + 26
            neuron death in response to hydrogen peroxide + 7
            positive regulation of hydrogen peroxide-induced cell death + 7
            regulation of hydrogen peroxide-induced cell death + 35
Path 2
Term Annotations click to browse term
  biological_process 19317
    response to stimulus 10411
      response to stress 3957
        response to oxidative stress 533
          response to reactive oxygen species 301
            response to hydrogen peroxide 195
              cellular response to hydrogen peroxide 127
                cell death in response to hydrogen peroxide 39
                  hydrogen peroxide-mediated programmed cell death + 15
                  negative regulation of hydrogen peroxide-induced cell death + 26
                  neuron death in response to hydrogen peroxide + 7
                  positive regulation of hydrogen peroxide-induced cell death + 7
                  regulation of hydrogen peroxide-induced cell death + 35
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.