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ONTOLOGY REPORT - ANNOTATIONS


Term:neuron death in response to hydrogen peroxide
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Accession:GO:0036476 term browser browse the term
Definition:Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2).
Comment:This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate.
Synonyms:exact_synonym: hydrogen peroxide-induced neuron death;   neuron death in response to H2O2;   neuronal cell death in response to hydrogen peroxide


show annotations for term's descendants       view all columns           Sort by:
 
negative regulation of hydrogen peroxide-induced neuron death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbxo7 F-box protein 7 JBrowse link 7 23,815,246 23,843,505 RGD:1624291
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1624291
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:1624291
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
G Reg3b regenerating family member 3 beta JBrowse link 4 109,467,272 109,470,510 RGD:9831400
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
RGD:1600115
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19335
    cellular process 17239
      cell death 2118
        cell death in response to oxidative stress 101
          cell death in response to hydrogen peroxide 39
            neuron death in response to hydrogen peroxide 7
              negative regulation of hydrogen peroxide-induced neuron death + 7
              neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 2
              regulation of hydrogen peroxide-induced neuron death + 7
Path 2
Term Annotations click to browse term
  biological_process 19335
    response to stimulus 10393
      cellular response to stimulus 8718
        cellular response to stress 1955
          cellular response to chemical stress 408
            cellular response to oxidative stress 337
              cellular response to reactive oxygen species 203
                cellular response to hydrogen peroxide 127
                  cell death in response to hydrogen peroxide 39
                    neuron death in response to hydrogen peroxide 7
                      negative regulation of hydrogen peroxide-induced neuron death + 7
                      neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 2
                      regulation of hydrogen peroxide-induced neuron death + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.