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ONTOLOGY REPORT - ANNOTATIONS


Term:intrinsic apoptotic signaling pathway in response to hydrogen peroxide
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Accession:GO:0036481 term browser browse the term
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).
Synonyms:exact_synonym: hydrogen peroxide-induced intrinsic apoptotic signaling pathway;   intrinsic apoptotic signaling pathway in response to H2O2
 broad_synonym: hydrogen peroxide-induced apoptosis
 related_synonym: H2O2-induced intrinsic apoptotic signaling pathway


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intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd10 programmed cell death 10 ISO UniProtKB:O00506 (PMID:22652780) RGD PMID:22652780 NCBI chr 2:173,966,701...174,012,730
Ensembl chr 2:173,967,080...174,012,676
JBrowse link
G Stk25 serine/threonine kinase 25 ISO UniProtKB:Q9BUL8 (PMID:22652780) RGD PMID:22652780 NCBI chr 9:100,767,578...100,779,715
Ensembl chr 9:100,767,579...100,779,715
JBrowse link
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase ISO
IEA
UniProtKB:Q99LX0 (PMID:14652021)
(MGI:5613479|PMID:14652021)
GO_REF:0000107
RGD
Ensembl
PMID:14652021 GO_REF:0000107, MGI:5613479 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pink1 PTEN induced kinase 1 ISO (PMID:21177249), (PMID:23261939) RGD PMID:21177249, PMID:23261939 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsph1 heat shock protein family H (Hsp110) member 1 ISO (MGI:3822965|PMID:18681888) RGD PMID:18681888 MGI:3822965 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Pink1 PTEN induced kinase 1 IMP
ISO
PMID:17579517
(PMID:17579517)
RGD PMID:17579517, PMID:17579517 RGD:8693356 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Trap1 TNF receptor-associated protein 1 IMP PMID:17579517 ParkinsonsUK-UCL PMID:17579517 RGD:8693356 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cell death 2144
        cell death in response to oxidative stress 106
          intrinsic apoptotic signaling pathway in response to oxidative stress 47
            intrinsic apoptotic signaling pathway in response to hydrogen peroxide 6
              negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 4
              neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 2
              positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 0
              regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 4
Path 2
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to stress 4062
        cellular response to stress 1981
          cellular response to chemical stress 418
            cellular response to oxidative stress 347
              cellular response to reactive oxygen species 205
                cellular response to hydrogen peroxide 131
                  cell death in response to hydrogen peroxide 39
                    hydrogen peroxide-mediated programmed cell death 15
                      intrinsic apoptotic signaling pathway in response to hydrogen peroxide 6
                        negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 4
                        neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 2
                        positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 0
                        regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.