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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of translation in response to endoplasmic reticulum stress
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Accession:GO:0036490 term browser browse the term
Definition:Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.
Synonyms:exact_synonym: regulation of translation in response to ER stress


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eiF2alpha phosphorylation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO
ISS
(PMID:25329545)
(PMID:17707796)
GO_REF:0000024
RGD
UniProt
PMID:17707796, PMID:25329545 GO_REF:0000024 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (PMID:25329545) RGD PMID:25329545 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 ISO
ISS
(PMID:22064321)
GO_REF:0000024
(MGI:MGI:5617428|PMID:25329545)
RGD
UniProt
PMID:22064321, PMID:25329545 GO_REF:0000024, MGI:MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Nck1 NCK adaptor protein 1 ISO (PMID:14676213), (PMID:16835242)
UniProtKB:O55033 (MGI:MGI:5613475|PMID:16835242), (MGI:MGI:5613478|PMID:14676213)
RGD PMID:14676213, PMID:16835242 MGI:MGI:5613475, MGI:MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO (PMID:16835242)
UniProtKB:Q99M51 (MGI:MGI:5613475|PMID:16835242), (MGI:MGI:5613478|PMID:14676213)
RGD PMID:14676213, PMID:16835242 MGI:MGI:5613475, MGI:MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (MGI:MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:MGI:5613475 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B ISO (MGI:MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:MGI:5613475 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 ISO MGI:MGI:4456438 (MGI:MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
negative regulation of translation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:1333015|PMID:9930704) RGD PMID:9930704 MGI:MGI:1333015 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Sesn2 sestrin 2 ISO (PMID:24947615)
(MGI:MGI:5688277|PMID:24947615)
RGD PMID:24947615 MGI:MGI:5688277 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (PMID:21518769) RGD PMID:21518769 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
positive regulation of translation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3, X-linked ISO (PMID:29062139) RGD PMID:29062139 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 ISO (PMID:29062139) RGD PMID:29062139 NCBI chr11:83,907,659...83,927,683
Ensembl chr11:83,908,109...83,926,524
JBrowse link
G Nck1 NCK adaptor protein 1 ISO (PMID:14676213)
UniProtKB:O55033 (MGI:MGI:5613478|PMID:14676213)
RGD PMID:14676213 MGI:MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO UniProtKB:Q99M51 (MGI:MGI:5613478|PMID:14676213) RGD PMID:14676213 MGI:MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
positive regulation of translation initiation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 ISO
ISS
(MGI:MGI:5617428|PMID:25329545)
GO_REF:0000024
RGD
UniProt
PMID:25329545 GO_REF:0000024, MGI:MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO
ISS
(MGI:MGI:3582244|PMID:11106749)
GO_REF:0000024
RGD
UniProt
PMID:11106749 GO_REF:0000024, MGI:MGI:3582244 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (MGI:MGI:5605960|PMID:11381086) RGD PMID:11381086 MGI:MGI:5605960 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to stress 4061
        cellular response to stress 1982
          response to endoplasmic reticulum stress 261
            regulation of translation in response to endoplasmic reticulum stress 11
              negative regulation of translation in response to endoplasmic reticulum stress + 2
              positive regulation of translation in response to endoplasmic reticulum stress + 5
              regulation of translation initiation in response to endoplasmic reticulum stress + 8
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      nitrogen compound metabolic process 10390
        cellular nitrogen compound metabolic process 6696
          cellular amide metabolic process 1533
            peptide metabolic process 1271
              peptide biosynthetic process 1117
                translation 1099
                  regulation of translation 382
                    regulation of translation in response to stress 22
                      regulation of translation in response to endoplasmic reticulum stress 11
                        negative regulation of translation in response to endoplasmic reticulum stress + 2
                        positive regulation of translation in response to endoplasmic reticulum stress + 5
                        regulation of translation initiation in response to endoplasmic reticulum stress + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.